DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and acs-1

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	119/508 - (23%)
Similarity:	187/508 - (36%)	Gaps:	101/508 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VCQISDS-------EGVEVTFGQALTWAIRIAQQLKSRGLDHKDIIGISARNTTYIMPTAVACFF 102
            |.|:.|.       ||:..|:.|..|.|..:|..|...||...|.|||...||.....|..|...
Worm    76 VDQVPDKEFLIFKREGIRKTYSQVATDAENLACGLLHLGLKKGDRIGIWGPNTYEWTTTQFASAL 140

  Fly   103 HGTPFQSANPILEESTLKHLYNISKPKII-------FTDADHYDKLYSATSAFKPEIILTTGTKD 160
            .|....:.||..:...|:  |.|.|..|.       |..:::|..:    ....||:.|....|.
Worm   141 AGMVLVNINPSYQSEELR--YAIEKVGIRALITPPGFKKSNYYQSI----KDILPEVTLKEPGKS 199

  Fly   161 GVLS-----IQDLLAPTKTEFFY-----QPTPLKEG----------------PSQTVAILTSSGT 199
            |:.|     .|.|:...:.:..|     ....:|.|                |..::.|..:|||
Worm   200 GITSRNFTCFQHLIMFDEEDKIYPGAWKYTDVMKMGTEEDRHHLSKIERETQPDDSLNIQYTSGT 264

  Fly   200 TGMPKAVCISNDILTQETVFVNGYDTIFISASLDWITGLWA------TIFSTVN------GCTRI 252
            ||.||..     .||...|..|.:           ..||.|      ||....|      ||...
Worm   265 TGQPKGA-----TLTHHNVLNNAF-----------FVGLRAGYSEKKTIICIPNPLYHCFGCVMG 313

  Fly   253 ISSKPFAADYFVYLVSKYSITYAL--IPPEHCCSLLDCPTATPEKLGSLTKLNFG-----GGRMT 310
            :.:........|:....:....||  |..|.|.:|...||...:.:......|:.     .|.:.
Worm   314 VLAALTHLQTCVFPAPSFDALAALQAIHEEKCTALYGTPTMFIDMINHPEYANYNYDSIRSGFIA 378

  Fly   311 QA--TVERVKKLAPNGVLNS---SYGMTEVGFIVF-----NHGHLKLTAAGNPLPGIQVKIVDDD 365
            .|  .:...::|..:..:..   .||.||...:.|     :....::.:.|:.:..::..|||..
Worm   379 GAPCPITLCRRLVQDMHMTDMQVCYGTTETSPVSFMSTRDDPPEQRIKSVGHIMDHLEAAIVDKR 443

  Fly   366 GNQLGVNQTGEIIVHNGFS-----WNGYFADPEATKAMQDEEGWFHTGDMGYFDEDDYLYMTDRK 425
            ...:.....||:|| .|:|     ||    ..|.||....::.|:||||:....::..:.:..|.
Worm   444 NCIVPRGVKGEVIV-RGYSVMRCYWN----SEEQTKKEITQDRWYHTGDIAVMHDNGTISIVGRS 503

  Fly   426 KEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYDETQGDVPGALVVREDNA 478
            |:::...|..::|.|||..:.:...|:.|.::||.||..|:|..|.|...::|
Worm   504 KDMIVRGGENIYPTEVEQFLFKHQSVEDVHIVGVPDERFGEVVCAWVRLHESA 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	119/508 (23%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	118/507 (23%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	119/508 (23%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	77/326 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910