DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and acs-16

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_490859.1	Gene:	acs-16 / 171714	WormBaseID:	WBGene00018579	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	561	Identity:	122/561 - (21%)
Similarity:	216/561 - (38%)	Gaps:	102/561 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PQNNPFKPETSLGRIIFKNMRNWPKNVCQISDSEGVEVTFGQALTWAIRIAQQLKSRGLDHKDII 83
            |:...|..:| :.::|:  .::....|..:.|||.:.:||.:.::....:|....|.||...|.:
Worm    26 PKQIDFDSQT-IPQLIY--TKSEMDRVAAVFDSEKLSLTFSKIVSEMESLAAGFLSIGLKQGDRV 87

  Fly    84 GISARNTTYIMPTAVACFFHGTPFQSANPILEES-TLKHLYNISKPKIIFT------DADHYDKL 141
            .::..|.:.:|..|:||...|..|..|||....| :||....:.:.:.|..      :|||.:.|
Worm    88 LVAGSNHSQVMLCALACSRAGLVFSLANPNYPNSYSLKRALELGEFQCIVCFRAHQYEADHLNNL 152

  Fly   142 Y---------SATSAFKPEII-----LTTGTKD----GVLSIQDLLAPTKTEFFYQPTPLKEGPS 188
            .         |.....|.|::     :....:|    |..::.::...:..|...:.....:..|
Worm   153 LLEIAPELMRSRKGQLKSELLPKLTHVILAEEDHKHAGTFTLSEVFLKSSKEKIAKLPDFSKWSS 217

  Fly   189 QTVAILT-SSGTTGMPKAVCISNDILTQETVFVNGYDTIFISASLD--WITGLWATIFSTVNGCT 250
            ..:|.|. :.||||.||.:.:|:      ...:||...:..:..::  .:......||..  ...
Worm   218 HKLACLQFTLGTTGAPKLIALSH------YQMLNGARAVAAAFGINDKHVLACALPIFRI--AIF 274

  Fly   251 RIISSKPFAADYFVYL-------------VSKYSITYALIPPEHCCSLLDCPTATPEKLGSLTKL 302
            .:|...||..:..:..             ||||..|..|........||........||.:|..:
Worm   275 NLICLSPFLTECRIIFPDATPLPKNLFSSVSKYRCTTLLSNGAALRLLLKISQTQRVKLSALENI 339

  Fly   303 NFGGGRMTQATVERVKKLAPN-GVLNSSYGMTEVGFI-VFNHGHLKLTA-AGNPLPGIQVKIVDD 364
            ...|.|:::..::.:|..|.| .::...|.:||.|.| :....:...|. .|..:.|.:..::..
Worm   340 LLIGDRVSKEVLKLIKVQAENVKIIAVGYLLTETGSIPLMGDQNSDFTRNVGKAIAGYEAHLIPL 404

  Fly   365 DG--NQLGVNQTGEII--VHNGFSWNGYFADPEATKAMQDEEGWFHTGDMGYFDEDDYLYMTDRK 425
            ||  ||:...:.|:::  |:.|.::.||..|   ||.   :|.|..|||:|..||:..:
Worm   405 DGSENQVETGKLGKLLIRVYYGSTFMGYAPD---TKG---KEKWVDTGDIGRMDENGAI------ 457

  Fly   426 KEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYD----ETQGD-VPGALVVRED-----NATL 480
                          ||.|..|:|...|..|::..::    ..|.| :.|..||...     .|..
Worm   458 --------------EVVASEDDLIYDKNNCLVEHWNLERLLNQNDLIKGVQVVSRGRGQPVTAVC 508

  Fly   481 TAQQVIDHVAKRLPDIQKQLRAG-------VQFADEIPQNH 514
            .|:....|.||...:::...|:.       ..|.|:.|:.|
Worm   509 VARSTQFHAAKLKDELKSMCRSHHFVAPDVFAFVDDFPRVH 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	122/561 (22%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	117/534 (22%)
acs-16	NP_490859.1	CaiC	35..565	CDD:223395	120/552 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810