Protein Alignment Adk1 and ADK

DIOPT Version :10

• Sequence 1: NP_731676.2
• Gene: Adk1 / 41476
• FlyBaseID: FBgn0037995
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_006712.2
• Gene: ADK / 132
• HGNCID: 257
• Length: 362
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 142/343 - (41%)
• Similarity: 203/343 - (59%)
• Gaps: 5/343 - (1%)

  Fly    52 LPEGILMGFGNPLLDITCTVEDNVILEKYGLEANAAIIADEKHDALFDELMNMENVIYSAGGACQ 116
            |.|.||.|.|||||||:..| |...|:||.|:.|..|:|::||..|||||:....|.|.|||:.|
Human    21 LRENILFGMGNPLLDISAVV-DKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQ 84

  Fly   117 NSMRIFQWIVQTPFR-AVFIGSVGKDKLGDRIEKRAKSDGLLTLYQLKEELPTGSCAVIINGPNR 180
            ||:::.||::|.|.: |.|.|.:|.||.|:.::::|....:...|..:.|.|||:||..|.|.||
Human    85 NSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNR 149

  Fly   181 SLVANLGAASLF-SDDWIDEDDNICALDRAEYFYFTGFFLAVCPPAVERVARMCCETNRIMILNF 244
            ||:|||.||:.: .:..:|.:.|...:::|...|..||||.|.|.:|.:||....|.|||..||.
Human   150 SLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNL 214

  Fly   245 SAVFVLQMQKEALGNILQYVDIIICNKEEAIAFSDTNDWKTKNIFEIGSRLQQMPKENT-RPRLV 308
            ||.|:.|..||:|..::.||||:..|:.||..|:....::||:|.||..:.|.:||.|: |.|:|
Human   215 SAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIV 279

  Fly   309 MITDAVCPVLVFQDNDRVLEYPVPPVKQGEIFDTNGCGDAFVGGFLAMYVQRMPLDYCIRTGIFA 373
            :.|......::..::: |..:.|....|.||.||||.|||||||||:..|...||..|||.|.:|
Human   280 IFTQGRDDTIMATESE-VTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYA 343

  Fly   374 SQQVLHVVGVQIDKLPKF 391
            :..::...|....:.|.|
Human   344 ASIIIRRTGCTFPEKPDF 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adk1	NP_731676.2	adenosine_kinase	54..382	CDD:238573	138/330 (42%)
ADK	NP_006712.2	Nuclear localization signal. /evidence=ECO:0000269|PubMed:19635462	8..16
		ribokinase_pfkB_like	29..361	CDD:469648	136/333 (41%)