Protein Alignment eIF3d2 and EIF3D

DIOPT Version :10

• Sequence 1: NP_731675.1
• Gene: eIF3d2 / 41475
• FlyBaseID: FBgn0037994
• Length: 551
• Species: Drosophila melanogaster
• Sequence 2: NP_003744.1
• Gene: EIF3D / 8664
• HGNCID: 3278
• Length: 548
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 298/550 - (54%)
• Similarity: 393/550 - (71%)
• Gaps: 23/550 - (4%)

  Fly     5 APFIKPYVEYNEHGWGPCEVPE--LDVPYQPFCKSDRLGKICDWT-AMVPEKKFPSKYASTFGNN 66
            |.|:.|.::.|..|||||.|||  .|:|||||.|.|||||:.||| |...:|::.:||:|.||..
Human     2 AKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGG 66

  Fly    67 SQYAYFYEDDDSTFHLVDTTGSKATKPYQRGRYRPNMRNNVRSRGRTGRGTPNIASLGGSTAGGA 131
            ||||||:|:|:|:|.||||..::.| .|||.|.|...||..|.:.|......|:..|
Human    67 SQYAYFHEEDESSFQLVDTARTQKT-AYQRNRMRFAQRNLRRDKDRRNMLQFNLQIL-------- 122

  Fly   132 TASTTKYGKGRNTRNTQNMGRRFG-----RNAPTRIRESSVMVQSDWVSIEEIDFPRLLKLALPN 191
             ..:.|..:....|..:...::||     .....:.|:|||.|:|||...||:|||:|:|:....
Human   123 -PKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLE 186

  Fly   192 IKDGKDIATCGWLEFYDKLYDRVNLRNEKPLQKMDRVVHTVTTTDDPVIRRLSRTMGNVFATDEI 256
            :.:.:||..||.||:|||.:||:..|:||||:.:.|:.||||||||||||:|::|.|||||||.|
Human   187 VSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAI 251

  Fly   257 LSTIMCCTRSNYSWDVVVEKLGTKVFLDKRYNDQFDLLTVNETSVEPPMDEEGSINSAHSLAMEA 321
            |:|:|.||||.||||:||:::|:|:|.|||.|..||||||:||:.|||.||..|.||..:|||||
Human   252 LATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEA 316

  Fly   322 TLINHNFSQQVLRIGDQEPRFMFEEPNPFEEPGVD---LASIGYRYRQWDLGNDVVLIARCKHNG 383
            |.||||||||.||:|.:  |:.|..||||.|..:|   :||:.||||:|.||:|:.||.||:|:|
Human   317 TYINHNFSQQCLRMGKE--RYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDG 379

  Fly   384 VIQGPNGDVQFLSIKALNEWDSKVTNSVEWRQKLDTQRGAVLASELRNNACKLARWTVEAVLAGS 448
            |:.|.||:|.|::||.||||||:..|.|:||||||:|||||:|:||:||:.||||||..|:||||
Human   380 VMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGS 444

  Fly   449 DQLKLGYVSRMNPRDHLRHVILGTQQFKPQEFATQINLNMDNAWGVLRCLIDLVMRQPDGKYLIM 513
            :.||||||||.:.:|..||||||||||||.|||:||||:::||||:|||:||:.|:..:|||||:
Human   445 EYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLIL 509

  Fly   514 KDPNKPMIRLYDVPENAFDSDGDEEEESSD 543
            |||||.:||:|.:|:..|.||.|||||..:
Human   510 KDPNKQVIRVYSLPDGTFSSDEDEEEEEEE 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3d2	NP_731675.1	eIF-3_zeta	7..525	CDD:461547	287/528 (54%)
EIF3D	NP_003744.1	eIF-3_zeta	4..521	CDD:461547	287/528 (54%)
		RNA gate. /evidence=ECO:0000250|UniProtKB:K7IM66	285..299		9/13 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..548		9/16 (56%)