DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3d2 and eIF3d1

DIOPT Version :9

Sequence 1:	NP_731675.1	Gene:	eIF3d2 / 41475	FlyBaseID:	FBgn0037994	Length:	551	Species:	Drosophila melanogaster
Sequence 2:	NP_524463.2	Gene:	eIF3d1 / 42789	FlyBaseID:	FBgn0040227	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	365/549 - (66%)
Similarity:	455/549 - (82%)	Gaps:	18/549 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNYAPFIKPYVEYNEHGWGPCEVPEL--DVPYQPFCKSDRLGKICDWT-AMVPEKKFPSKYASTF 63
            :.:..|.||.|::||.||||||:|:.  |||||||.|:|||||||||| ....:||:.:||||:|
  Fly     9 AQFPSFEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSF 73

  Fly    64 GNNSQYAYFYEDDDSTFHLVDTTGSKATK-PYQRGRYRPNMRNNVRSRGRTGRGTPNIASLGGST 127
            |...||:|::|:|::|||||||  ::..| |:||||:| ||||:...|||..|        ||..
  Fly    74 GTGIQYSYYHEEDETTFHLVDT--ARVQKPPHQRGRFR-NMRNSRSGRGRNAR--------GGLN 127

  Fly   128 AGGATASTTKYGKGRNTRNTQNMGRRFG-RNAPTRIRESSVMVQSDWVSIEEIDFPRLLKLALPN 191
            ..|.|..:.|..|.|:.|:.:.||::|| |..|.::|||||.|::||.||||:|||||:||:|||
  Fly   128 THGMTTLSGKNVKARDPRHGRGMGKKFGHRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPN 192

  Fly   192 IKDGKDIATCGWLEFYDKLYDRVNLRNEKPLQKMDRVVHTVTTTDDPVIRRLSRTMGNVFATDEI 256
            ||:|.||.|||.||:|||.|||:|::|||||||:||:||||||||||||||||:|:|||||||.|
  Fly   193 IKEGVDIVTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAI 257

  Fly   257 LSTIMCCTRSNYSWDVVVEKLGTKVFLDKRYNDQFDLLTVNETSVEPPMDEEGSINSAHSLAMEA 321
            |:||||.||||||||:|:||:|.|||:|||.:.:||||||||:|||||.|::.|.||..:||:||
  Fly   258 LATIMCSTRSNYSWDIVIEKVGDKVFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEA 322

  Fly   322 TLINHNFSQQVLRIGDQEPRFMFEEPNPF--EEPGVDLASIGYRYRQWDLGNDVVLIARCKHNGV 384
            |.||||||||||:.|||||::.|||.|||  |:..:.:||:||||::|:||:|:||:|||:|:||
  Fly   323 TFINHNFSQQVLKTGDQEPKYKFEESNPFISEDEDIQVASVGYRYKKWELGSDIVLVARCEHDGV 387

  Fly   385 IQGPNGDVQFLSIKALNEWDSKVTNSVEWRQKLDTQRGAVLASELRNNACKLARWTVEAVLAGSD 449
            :|.|:|:.||::||||||||||:.|.||||||||||||||||:||||||||||:|||:|||||||
  Fly   388 LQTPSGEPQFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSD 452

  Fly   450 QLKLGYVSRMNPRDHLRHVILGTQQFKPQEFATQINLNMDNAWGVLRCLIDLVMRQPDGKYLIMK 514
            |||||||||:|||||.||||||||||||.||||||||:||||||:|||:|||||:|.||||||||
  Fly   453 QLKLGYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMK 517

  Fly   515 DPNKPMIRLYDVPENAFDSDGDEEEESSD 543
            |||||:|||||:|:|.||||..::.|..|
  Fly   518 DPNKPIIRLYDIPDNTFDSDDSDDGEGDD 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3d2	NP_731675.1	eIF-3_zeta	7..525	CDD:282888	355/524 (68%)
eIF3d1	NP_524463.2	eIF-3_zeta	14..528	CDD:282888	355/524 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470225
Domainoid	1	1.000	397	1.000	Domainoid score	I139
eggNOG	1	0.900	-	-		E1_KOG2479
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	412	1.000	Inparanoid score	I450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1030308at2759
OrthoFinder	1	1.000	-	-		FOG0004086
OrthoInspector	1	1.000	-	-		otm26595
orthoMCL	1	0.900	-	-		OOG6_102252
Panther	1	1.100	-	-	P	PTHR12399
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R379
SonicParanoid	1	1.000	-	-		X2834
	12	11.830