DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3d2 and Eif3d

DIOPT Version :9

Sequence 1:	NP_731675.1	Gene:	eIF3d2 / 41475	FlyBaseID:	FBgn0037994	Length:	551	Species:	Drosophila melanogaster
Sequence 2:	NP_001004283.1	Gene:	Eif3d / 362952	RGDID:	1303255	Length:	548	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	295/550 - (53%)
Similarity:	394/550 - (71%)	Gaps:	23/550 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 APFIKPYVEYNEHGWGPCEVPE--LDVPYQPFCKSDRLGKICDWT-AMVPEKKFPSKYASTFGNN 66
            |.|:.|.::.|..|||||.|||  .|:|||||.|.|||||:.||| |...:|::.:||:|.||..
  Rat     2 AKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGG 66

  Fly    67 SQYAYFYEDDDSTFHLVDTTGSKATKPYQRGRYRPNMRNNVRSRGRTGRGTPNIASLGGSTAGGA 131
            ||||||:|:|:::|.||||..::.| .|||.|.|...||..|.:.|......|:.:|
  Rat    67 SQYAYFHEEDETSFQLVDTARTQKT-AYQRNRMRFAQRNLRRDKDRRNMVQFNLQTL-------- 122

  Fly   132 TASTTKYGKGRNTRNTQNMGRRFG-----RNAPTRIRESSVMVQSDWVSIEEIDFPRLLKLALPN 191
             ..:.|..:....|..:...::||     .....:.|:|||.|:|||...||:|||:|:|:....
  Rat   123 -PKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLE 186

  Fly   192 IKDGKDIATCGWLEFYDKLYDRVNLRNEKPLQKMDRVVHTVTTTDDPVIRRLSRTMGNVFATDEI 256
            :.:.:||..||.||:|||.:||:..|:||||:.:.|:.||||||||||||:|::|.|||||||.|
  Rat   187 VSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAI 251

  Fly   257 LSTIMCCTRSNYSWDVVVEKLGTKVFLDKRYNDQFDLLTVNETSVEPPMDEEGSINSAHSLAMEA 321
            |:|:|.||||.||||:||:::|:|:|.|||.|..||||||:||:.|||.||..|.||..:|||||
  Rat   252 LATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEA 316

  Fly   322 TLINHNFSQQVLRIGDQEPRFMFEEPNPFEEPGVD---LASIGYRYRQWDLGNDVVLIARCKHNG 383
            |.||||||||.||:|.:  |:.|..||||.|..:|   :||:.||||:|.||:|:.||.||:|:|
  Rat   317 TYINHNFSQQCLRMGRE--RYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDG 379

  Fly   384 VIQGPNGDVQFLSIKALNEWDSKVTNSVEWRQKLDTQRGAVLASELRNNACKLARWTVEAVLAGS 448
            |:.|.||:|.|::||.||||||:..|.|:||||||:|||||:|:||:||:.||||||..|:||||
  Rat   380 VMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGS 444

  Fly   449 DQLKLGYVSRMNPRDHLRHVILGTQQFKPQEFATQINLNMDNAWGVLRCLIDLVMRQPDGKYLIM 513
            :.||||||||.:.:|..||||||||||||.|||:||||:::||||:|||:||:.|:..:|||||:
  Rat   445 EYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLIL 509

  Fly   514 KDPNKPMIRLYDVPENAFDSDGDEEEESSD 543
            |||||.:||:|.:|:..|.|:.|||:|..:
  Rat   510 KDPNKQVIRVYSLPDGTFSSEEDEEDEEEE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3d2	NP_731675.1	eIF-3_zeta	7..525	CDD:282888	286/528 (54%)
Eif3d	NP_001004283.1	eIF-3_zeta	4..521	CDD:398661	286/528 (54%)
		RNA gate. /evidence=ECO:0000250\|UniProtKB:K7IM66	285..299		9/13 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..548		7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353666
Domainoid	1	1.000	624	1.000	Domainoid score	I169
eggNOG	1	0.900	-	-		E1_KOG2479
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	644	1.000	Inparanoid score	I776
OMA	1	1.010	-	-		QHG53861
OrthoDB	1	1.010	-	-		D1030308at2759
OrthoFinder	1	1.000	-	-		FOG0004086
OrthoInspector	1	1.000	-	-		otm45190
orthoMCL	1	0.900	-	-		OOG6_102252
Panther	1	1.100	-	-	O	PTHR12399
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2834
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770