DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3d2 and moe1

DIOPT Version :9

Sequence 1:	NP_731675.1	Gene:	eIF3d2 / 41475	FlyBaseID:	FBgn0037994	Length:	551	Species:	Drosophila melanogaster
Sequence 2:	NP_594625.1	Gene:	moe1 / 2543412	PomBaseID:	SPAC637.07	Length:	567	Species:	Schizosaccharomyces pombe

Alignment Length:	573	Identity:	238/573 - (41%)
Similarity:	338/573 - (58%)	Gaps:	74/573 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WGPCEVPEL--DVPYQPFCKSDRLGKICDWTAMVPEK-------------KFPSKYAS-TFGNNS 67
            |||.|..::  |:||.||.|.||||||.||:...|:.             :|..:|.: .:|.:|
pombe    17 WGPPETEQIGGDIPYAPFSKGDRLGKIADWSVDQPKDGREQRGRQGAFAGRFRDQYQTYGYGASS 81

  Fly    68 QYAYFYEDDDSTFHLVDTTGSKATKPYQRG---RYRPNMRN-----NVRSRG----RTGRGTPNI 120
            .:.|.:.:|:|:|.::|           ||   |.|.:.||     .||.||    |.||| ...
pombe    82 IFGYQHSEDESSFSVID-----------RGSVNRTRTSARNGGTLLKVRGRGQNVQRGGRG-GRY 134

  Fly   121 ASLGGSTAGGATASTTKYGKGRNTRNTQNMGRRFG---RNAPTRIRESSVMVQSDWVSIEEIDFP 182
            .|.||..||....|.:....|..       |||||   .:...|:|.:||.|..||..::|::|.
pombe   135 GSSGGRGAGDTVVSRSSGAGGAR-------GRRFGWKDYDKHQRLRNASVTVGDDWQLLDEVEFS 192

  Fly   183 RLLKL----ALPNIKDGKDIATCGWLEFYDKLYDRVNLRNEKPLQKMDRVVHTVTTTDDPVIRRL 243
            .|.||    |.|...|     :.|::..|||.:|::::::|||||.:|||.:..|||:||||::|
pombe   193 HLSKLNLAAAAPVTVD-----SYGYIYPYDKSFDKIHVKSEKPLQALDRVHYNPTTTEDPVIQKL 252

  Fly   244 S-RTMGNVFATDEILSTIMCCTRSNYSWDVVVEKLGTKVFLDKRYNDQFDLLTVNETSVEPPMDE 307
            : .:..|:|.||.|||.:||.|||.|.||:|:.....|:|.|||....||.|||||.:.:.|||.
pombe   253 ALNSDANIFITDSILSLLMCSTRSVYPWDIVITHQSGKLFFDKREGGPFDYLTVNENAYDSPMDA 317

  Fly   308 EG--SINSAHSLAMEATLINHNFSQQVLRIGDQEPRFMFEEPNPF---EEPGVDLASIGYRYRQW 367
            :.  .:||..:|::|||.||.||..|.||..::| ::....||||   :|....||:.||.||..
pombe   318 DNREGVNSPGALSVEATYINQNFCVQALRETEEE-KYKLPHPNPFYNSKEESEPLAAHGYIYRDV 381

  Fly   368 DLG-----NDVVLIARCKHNGVIQGPNGDVQFLSIKALNEWDSKVTN---SVEWRQKLDTQRGAV 424
            ||.     ..|.|:.|.:.:|.::.|..|||::|||||||:|.|.||   ||:||.||::|||||
pombe   382 DLSLETDEKPVKLMVRTEVDGYVKNPANDVQYISIKALNEYDPKFTNVTGSVDWRSKLESQRGAV 446

  Fly   425 LASELRNNACKLARWTVEAVLAGSDQLKLGYVSRMNPRDHLRHVILGTQQFKPQEFATQINLNMD 489
            .|:|::||:||||||||||:|||.|.:|:|:|||.|.||...|.|||...:||.:.|:|:||::.
pombe   447 FATEMKNNSCKLARWTVEALLAGVDSMKVGFVSRSNARDAQHHGILGVVAYKPADLASQMNLSLS 511

  Fly   490 NAWGVLRCLIDLVMRQPDGKYLIMKDPNKPMIRLYDVPENAFDSDGDEEEESS 542
            |.||::|.:.|:.::.|||||:::||||:|::|||.||.|.|:.......|:|
pombe   512 NGWGIVRTIADVCLKMPDGKYVLVKDPNRPILRLYSVPPNTFEEAAGPSLEAS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3d2	NP_731675.1	eIF-3_zeta	7..525	CDD:282888	231/554 (42%)
moe1	NP_594625.1	eIF-3_zeta	5..547	CDD:282888	231/554 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	403	1.000	Domainoid score	I104
eggNOG	1	0.900	-	-		E1_KOG2479
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I358
OMA	1	1.010	-	-		QHG53861
OrthoFinder	1	1.000	-	-		FOG0004086
OrthoInspector	1	1.000	-	-		otm47196
orthoMCL	1	0.900	-	-		OOG6_102252
Panther	1	1.100	-	-	O	PTHR12399
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R379
SonicParanoid	1	1.000	-	-		X2834
TreeFam	1	0.960	-	-
	13	12.860