DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpn and ZAN

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_003377.2	Gene:	ZAN / 7455	HGNCID:	12857	Length:	2812	Species:	Homo sapiens

Alignment Length:	842	Identity:	179/842 - (21%)
Similarity:	267/842 - (31%)	Gaps:	297/842 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TIPSPVSAP-------VAAPVTPSAVAAPVQVVSPAAVAPAPAAPIAVTPVAPPPTLASVQPATV 62
            |:||....|       :....|.|.||....:::|.      ..|:.|.|..||
Human   497 TVPSGHQQPMQLIFKGIQGSNTASVVAMGFILINPG------TCPVKVLPELPP----------- 544

  Fly    63 TIPAPAPIAAASVAPVASVAPPVVAAPTPPAASPVSTPPVAVAQIPVAVSAPVAPPVAATPTPVA 127
                        |:||:|..|......|.........|.|::.:..|....|..|....|
Human   545 ------------VSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTEKPTVPKEKPT----- 592

  Fly   128 PIPVAAPVIAT--PPVAASAPTPAAVTPVVSPVIAT--PPVVPANTTVPVAAPVAAVPAAVPVVA 188
             ||...|.|:|  |.:.:..|.    .|...|.|.:  |.::....|:|...|  .:|:..|.::
Human   593 -IPTEKPTISTEKPTIPSEKPN----MPSEKPTIPSEKPTILTEKPTIPSEKP--TIPSEKPTIS 650

  Fly   189 PVLAPAVAPAVAPVVAETPAPPPVAEIPVATIPECVAPLIP--EVSVVATKPLAAAEPVVVAPPA 251
                 ...|.|......||.......:....|| ...|.||  :.|:...||..:.|..::   :
Human   651 -----TEKPTVPTEEPTTPTEETTTSMEEPVIP-TEKPSIPTEKPSIPTEKPTISMEETII---S 706

  Fly   252 TETPVVAPAAASPHVSVAPAVETAVVAPVSASTEPPVAAATLTTAPETPALAPVVAESQVAANTV 316
            ||.|.::|.                 .|...:.:|.:.....|.:||.|
Human   707 TEKPTISPE-----------------KPTIPTEKPTIPTEKSTISPEKP---------------- 738

  Fly   317 VATPPTPAPEPETIAPPVVAETPEVASVAVAETTPPVVPPVAAESIPAPVVATTPVPATLAVTDP 381
              |.||..|...|..|.:..|.|         |||...|.::.|.:..|.
Human   739 --TTPTEKPTIPTEKPTISPEKP---------TTPTEKPTISPEKLTIPT--------------- 777

  Fly   382 DVTASAVPELPPVIAPSPVPSAVAETPVDLAPPVLPPVAAEPVPAVVAEETPETPAPASAPVTIA 446
                    |.|.:  |:..|:...|.|                  .::.|.|.||...    |..
Human   778 --------EKPTI--PTEKPTIPTEKP------------------TISTEEPTTPTEE----TTI 810

  Fly   447 ALDIPEVAPVIAAPSDAPAEAPSAAAPIVSTPPTTASVPETTAPPAAVPTEPIDVSVLSEAAIET 511
            :.:.|.:          |.|.|:     :.|..||.||.|||     :.||.:.:
Human   811 STEKPSI----------PMEKPT-----LPTEETTTSVEETT-----ISTEKLTI---------- 845

  Fly   512 PVAPPVEVTTEVAVADVAPPEAAADLIIEPVEPPAPIPDLLEQTT---SVPAVEAAESTSSPIPE 573
            |:..|...|.:..:               |.|.|...|:.|...|   ::|    .|..:.||.|
Human   846 PMEKPTISTEKPTI---------------PTEKPTISPEKLTIPTEKLTIP----TEKPTIPIEE 891

  Fly   574 TSLPPPNEAVASPEVAVAPITAPEPIPEPEPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTS 638
            |::        |.|....|...|...|| :|:::|....||.|.|.          :|..||:.|
Human   892 TTI--------STEKLTIPTEKPTISPE-KPTISTEKPTIPTEKPT----------IPTEETTIS 937

  Fly   639 IPETTV--EYPV--AEKVLDPAITEAP-VTTQEPDVANINDGAPATEITTPAVEIVTAAAEVSDT 698
            ..:.|:  |.|.  .||:..|  ||.| ::|::|.:       |..::|
Human   938 TEKLTIPTEKPTISPEKLTIP--TEKPTISTEKPTI-------PTEKLT---------------- 977

  Fly   699 AIPLIDPPVPQEIAVAEIPETETKPAEVIVEQSTIPIEA--------PVPEVSKYAEPVIS-EAP 754
             ||...|.:|.|           ||        |||.|.        |.|..:..|..|:| .||
Human   978 -IPTEKPTIPTE-----------KP--------TIPTEKLTALRPPHPSPTATGLAALVMSPHAP 1022

  Fly   755 AAEVPITAGDNPDNTSVGISEVVPTIAEKAVEEVPTSEIPEQSSSP-SDSVPVAKITPLLRD 815
            :..:          |||.:.  ..|.:..:.|..|.:...|..:.| |...|.....||.|:
Human  1023 STPM----------TSVILG--TTTTSRSSTERCPPNARYESCACPASCKSPRPSCGPLCRE 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	34/168 (20%)
		rne	<109..300	CDD:236766	42/196 (21%)
		rne	<228..409	CDD:236766	35/182 (19%)
		rne	<331..594	CDD:236766	52/265 (20%)
		rne	<501..763	CDD:236766	62/278 (22%)
ZAN	NP_003377.2	MAM	41..203	CDD:306977
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..84
		MAM	211..367	CDD:306977
		MAM	373..535	CDD:306977	9/43 (21%)
		Atrophin-1	<540..1022	CDD:331285	153/729 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..884		100/499 (20%)
		66 X heptapeptide repeats (approximate) (mucin-like domain)	573..1041		148/704 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..929		9/35 (26%)
		TIL	1044..1093	CDD:307783	8/29 (28%)
		TILa	1095..1148	CDD:315397
		VWD	1156..1308	CDD:306577
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1302..1323
		C8	1349..1423	CDD:214843
		TIL	1426..1479	CDD:307783
		TILa	1481..1535	CDD:315397
		VWD	1542..1695	CDD:306577
		C8	1742..1808	CDD:312319
		TILa	1869..1924	CDD:315397
		VWD	1931..2084	CDD:306577
		C8	2149..2207	CDD:312319
		TIL	2211..2267	CDD:307783
		TILa	2269..2320	CDD:315397
		VWD	2331..2484	CDD:306577
		C8	2543..>2597	CDD:214843
		TILa	2654..2707	CDD:315397
		EGF	2712..2740	CDD:306513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900