DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpn and VWF

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_000543.3	Gene:	VWF / 7450	HGNCID:	12726	Length:	2813	Species:	Homo sapiens

Alignment Length:	796	Identity:	152/796 - (19%)
Similarity:	244/796 - (30%)	Gaps:	266/796 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 APVAAVPAAVPVVAPVLAPAVAPAVAPV--VAETPAPPPVAEIPVATIPECVAPLIPEVSVVATK 237
            ||...|....|          .|...||  |....|..|..:|....:..||.|....|..||.:
Human  1150 APACQVTCQHP----------EPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGR 1204

  Fly   238 PLAAAEPVVVAPPATE---------TPVVAPAAASPHVSVAPAVETAVVAPVSAST-------EP 286
            ..|:.:.|.:.|...|         ..:...|...|...|.|..:    ||||.:|       ||
Human  1205 RFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTD----APVSPTTLYVEDISEP 1265

  Fly   287 PV----------------AAATLTTAPETPALAPV-----------------VAESQVAANTVVA 318
            |:                .::.|:.|......|.|                 |.|....::..:.
Human  1266 PLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIG 1330

  Fly   319 TPPTPAP-EPETIAPPV------VAETPEVASVAVAETTPPVVPPVAAESIPAPVVATTPVPATL 376
            ......| |...||..|      ||.|.||....:.:....:..|.|:.             .||
Human  1331 LKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASR-------------ITL 1382

  Fly   377 AVTDPDVTASAVPELPPVIAPSPVPSAVAETPVDLA------PPVLPPVAAEPVPAVVAEETPET 435
                             ::..|..|..::...|...      ..::.||...|...:......|.
Human  1383 -----------------LLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEK 1430

  Fly   436 PAPASAPVTIAALDIPEVA--PVIAAPSDAPAEAPSAAAPIVSTPPTTASVPETTAPP--AAVPT 496
            .||.:....::::|..|..  .:::...|...|||         ||        |.||  |.|..
Human  1431 QAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAP---------PP--------TLPPDMAQVTV 1478

  Fly   497 EP--IDVSVL--SEAAIETPVAPPVEVTTEVAVADVAPPEAAADLIIE----------------- 540
            .|  :.||.|  ...::...||..:|.:.::..||....:...:.:|:
Human  1479 GPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYS 1543

  Fly   541 -------PVEPPAPIPDLLEQTTSVP---------------------AVEAAESTSSP---IPET 574
                   |........|:|::...:.                     .|...:...:|   ...|
Human  1544 YMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVT 1608

  Fly   575 SLPPPNEAVASP-EVAVAPI-TAP-------EPIPEPE-PSLATPTEPIPVEAP-VVIQEAVDAV 628
            ..|..:|....| ::.|.|| ..|       |.|..|. |.|....|.:|.||| :|:|....
Human  1609 GNPASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCS-- 1671

  Fly   629 EVPVTETSTSIPETTVEYPVAEKVLDPAITEAPVTTQEPDVANINDGA---PAT---EITTPAVE 687
                                .|.:..|.::.||..:|..||..:.||:   ||:   |:.:.|..
Human  1672 --------------------GEGLQIPTLSPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKA 1716

  Fly   688 IVTAA------AEVSDT---AIPLIDPP---VPQE---IAVAEIPETETKPAEV------IVEQS 731
            .::.|      .:||..   :|..||.|   ||::   :::.::.:.|..|:::      .|...
Human  1717 FISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYL 1781

  Fly   732 TIPIEAPVPEVSKYAEPVISEAPAAEV---------------PITAGDNPDNTSV-------GIS 774
            |..:....|..||....::::.....|               ||..||..|...:       |.|
Human  1782 TSEMHGARPGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDS 1846

  Fly   775 EVVPTIAEKAVEEVPT 790
            .||..   :.:|::||
Human  1847 NVVKL---QRIEDLPT 1859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766
		rne	<109..300	CDD:236766	35/158 (22%)
		rne	<228..409	CDD:236766	41/236 (17%)
		rne	<331..594	CDD:236766	55/332 (17%)
		rne	<501..763	CDD:236766	66/364 (18%)
VWF	NP_000543.3	VWD	35..179	CDD:395046
		C8	222..291	CDD:214843
		TIL	295..348	CDD:410995
		VWC	350..>394	CDD:327433
		VWD	377..540	CDD:214566
		C8	584..648	CDD:400886
		TIL	652..707	CDD:410995
		Amino-terminal	764..787
		E1	788..833
		TIL	<788..827	CDD:410995
		CX	826..853
		VWD	856..1011	CDD:214566
		C8	1053..1127	CDD:214843
		TIL	1146..1196	CDD:410995	14/55 (25%)
		VWA_N2	1198..1276	CDD:406551	19/81 (23%)
		VWA	1277..1449	CDD:214621	31/201 (15%)
		VWA	1498..1658	CDD:395045	25/159 (16%)
		VWA	1691..1862	CDD:395045	37/172 (22%)
		VWD	1950..2102	CDD:395046
		C8	2138..2199	CDD:400886
		TIL	2203..2254	CDD:410995
		E2	2216..2261
		VWC	2261..2321	CDD:214564
		VWC	2431..2494	CDD:214564
		Cell attachment site	2507..2509
		VWC	2582..2644	CDD:278520
		CT	2727..2808	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900