DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpn and MUC5B

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_002449.2	Gene:	MUC5B / 727897	HGNCID:	7516	Length:	5762	Species:	Homo sapiens

Alignment Length:	1098	Identity:	239/1098 - (21%)
Similarity:	341/1098 - (31%)	Gaps:	316/1098 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GTIPS-PVSAPVAAP-VTPSAVAAPVQVVSPAAVAPAPAAPIAVTPVAPP-PTLASVQP---ATV 62
            |..|| |.::..|.| .||.......::.:.|....:..:  ..||.:.| .|....:|   |||
Human  3669 GHCPSTPATSSTATPSSTPGTTWILTKLTTTATTTESTGS--TATPSSTPGTTWILTEPSTTATV 3731

  Fly    63 TIPAPAPIAAASVAPVASVAPPVVAAPTPPA----ASPVSTPPVA--------VAQIPVAVSAPV 115
            |:|..:...|:|....|........|.||..    |:|.|:|..|        .|..|.|.|...
Human  3732 TVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTA 3796

  Fly   116 APP---------VAATPTPVAPIPVAAP-------------------VIATPPVAASAPTPA--- 149
            .|.         ::.|.||.|.:..|.|                   ..||..||..:.||.
Human  3797 IPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTTRATGSVATPSSTPGTAH 3861

  Fly   150 ------------AVTPVVSPVIA-TPPVVPANTTVPVAAPVAAVPAAVPVVAPVLAPAVAPAVAP 201
                        .|||..||..| ||||..:.||.|..:.....|::||  .....|.|......
Human  3862 TTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTSGSTVTPSSVP--GTTHTPTVLTTTTT 3924

  Fly   202 VVA-----------ETPAPPPVAEIPVATIPEC-----------VAPLIPEVSVVATKPLAAAEP 244
            .||           :|...||.......||...           ..|:.|.::..||.|.|.:..
Human  3925 TVATGSMATPSSSTQTSGTPPSLITTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSST 3989

  Fly   245 VV--VAPPATETPVVAPAAASPH-VSVAPA----VETAVVAPVSAS------TEPPV------AA 290
            |.  .|...|.||.|....|:.| .|::|:    |.||..:..|.:      |||..      ||
Human  3990 VTPSSALGTTHTPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAA 4054

  Fly   291 ATLTTAPETPALAPVVAESQ------------------VAANTVVATP------------PTPAP 325
            .|.||...||||:.....|:                  .:..|..|||            ||.||
Human  4055 TTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSSPTSAP 4119

  Fly   326 ---------EPE---------------------------TIAPPVVAETPEVASVAVAETTP--- 351
                     ||:                           ..|...|.|.| :.....|:..|
Human  4120 ITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQP-LGLECRAQAQPGVP 4183

  Fly   352 ---------------------------------------------PVVPPVAAESIPAPVVATTP 371
                                                         |..|..::.::|:....||.
Human  4184 LGELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTAMPSSTPGTTW 4248

  Fly   372 V---PATLAVTDPDVTASAVPELPPVIAPSP-VPSAVAETPV---DLAPPVLPPVAAEPVPAVVA 429
            :   ..|.|.|.....::|.|...|..||.| |.::.|.||.   ..|.....|..|..:|.:.:
Human  4249 ILTELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSSSSPRTATTLPVLTS 4313

  Fly   430 EETPE-----TPAPASAPVTIAALDIPEVAPVIAAPSDAPAEAPSA--AAPIVSTPPTTASVPET 487
            ..|..     ||.|:|...|...|......||....:..|:..|..  .:.:::|..||.....:
Human  4314 TATKSTATSVTPIPSSTLGTTGTLPEQTTTPVATMSTIHPSSTPETTHTSTVLTTKATTTRATSS 4378

  Fly   488 TAPPAAVPTEPIDVSVLSEAAIET----PVAPP--------------VEVTTEVAVADVAPPEAA 534
            |:.|::.|.....::.|:.||..|    |.|.|              ...||..:....|.|.:.
Human  4379 TSTPSSTPGTTWILTELTTAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSST 4443

  Fly   535 AD---LIIEP------------------VEPPAPIPDLLEQTTSVPAVEAAEST--SSPIPETSL 576
            ..   ::.||                  .:..|..|. :..|.:.|.|.::::|  |||...|:|
Human  4444 PGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPH-VSTTATTPTVTSSKATPSSSPGTATAL 4507

  Fly   577 PPPNEAVASPEVAVAPITAPEPIPEPEPSL----------ATPTEPIPVEAPVVIQEAVDAVEVP 631
            |.......:|       ||......|..||          .|||..:....|....|.|
Human  4508 PALRSTATTP-------TATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETV------ 4559

  Fly   632 VTETSTSIPETTVEYPVAEKVLDPAITEAPV-TTQEPDVANINDGAPATEITTPAVEIVTAAAEV 695
              .|||.:..|.........|..|:.|.... ||:.|  .....|..||..::|...: |....:
Human  4560 --HTSTVLTATATTTGATGSVATPSSTPGTAHTTKVP--TTTTTGFTATPSSSPGTAL-TPPVWI 4619

  Fly   696 SDTAIPLIDPPVP--QEIAVAEIPETETKPAEVIVEQSTI----PIEAPVPEVSKYAEPVISEAP 754
            |.|..|....|..  ..:..:.||.| |..|.|:...:|.    .:..|.........|......
Human  4620 STTTTPTTTTPTTSGSTVTPSSIPGT-THTARVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTT 4683

  Fly   755 AAEVPITAGDNPDNTSVGISEVVPTIAEKAVEEVPTSEIPEQSSSP--SDSVPVAKIT 810
            |..:..|......:::.|.:.:.|.:...|.....||.....||||  :.::||...|
Human  4684 ATTITATGSTTNPSSTPGTTPITPVLTSTATTPAATSSKATSSSSPRTATTLPVLTST 4741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	54/218 (25%)
		rne	<109..300	CDD:236766	68/275 (25%)
		rne	<228..409	CDD:236766	65/317 (21%)
		rne	<331..594	CDD:236766	71/365 (19%)
		rne	<501..763	CDD:236766	67/319 (21%)
MUC5B	NP_002449.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..50
		VWD	70..223	CDD:214566
		C8	270..325	CDD:285899
		TIL	329..385	CDD:280072
		VWC_out	387..>432	CDD:214565
		VWD	414..578	CDD:214566
		C8	615..685	CDD:214843
		TIL	695..752	CDD:280072
		TIL	794..855	CDD:280072
		VWD	884..1041	CDD:214566
		C8	1078..1152	CDD:214843
		7 X Cys-rich subdomain repeats	1333..4228		121/563 (21%)
		Mucin2_WxxW	1340..1426	CDD:290069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1502
		Mucin2_WxxW	1508..1597	CDD:290069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1607..1783
		Mucin2_WxxW	1789..1878	CDD:290069
		11 X approximate tandem repeats, Ser/Thr-rich	1890..2199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1890..2019
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2031..2100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2114..2211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2242..2302
		Mucin2_WxxW	2320..2408	CDD:290069
		11 X approximate tandem repeats, Ser/Thr-rich	2419..2756
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2443..2462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2556..2861
		PARM	2675..>2860	CDD:293666
		Mucin2_WxxW	2877..2965	CDD:290069
		17 X approximate tandem repeats, Ser/Thr-rich	2976..3456
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3001..3049
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3256..3357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3371..3469
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3481..3561
		Mucin2_WxxW	3577..3665	CDD:290069
		11 X approximate tandem repeats, Ser/Thr-rich	3676..4013		81/340 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3699..3779		22/81 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3813..3917		27/105 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3956..4118		39/161 (24%)
		Mucin2_WxxW	4134..4222	CDD:290069	6/88 (7%)
		23 X approximate tandem repeats, Ser/Thr-rich	4233..4879		116/529 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4259..4389		32/129 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4428..4447		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4458..4527		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4541..4750		48/213 (23%)
		VWD	5064..5237	CDD:214566
		C8	5290..5351	CDD:285899
		VWC	5523..5586	CDD:214564
		CT	5660..5742	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900