DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpn and MUC6

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_005952.2	Gene:	MUC6 / 4588	HGNCID:	7517	Length:	2439	Species:	Homo sapiens

Alignment Length:	1059	Identity:	214/1059 - (20%)
Similarity:	340/1059 - (32%)	Gaps:	315/1059 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TIPSPVS-----APVAAPVTPSAVAA------------PVQVVSPAAVAPAP------------- 39
            |.|||.|     :|...|:.|:.:.:            |...|:|.|.:..|
Human  1236 TGPSPSSNHTPASPTQTPLLPATLTSSKPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPT 1300

  Fly    40 ---AAPIAVTPVAPPPTLASVQP---ATVTIPAPAPIAAASVAPVAS--VAPPVVAA------PT 90
               |...|....|.|.|.::.|.   .|:|:|.||....:...|.::  ..|...|.      ||
Human  1301 VTQATTRATASTASPATTSTAQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPT 1365

  Fly    91 PPAASPVSTPPVAVAQIPVAV-----------SAPVAPPVA-ATPTPVAPIPVAAPVIAT----- 138
            |.:.:..:||.......|.|.           :.|..|... :.||..:|:|...||.||
Human  1366 PASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHAT 1430

  Fly   139 -----------------PPVAASAPTPAAVTPVVSPVIA---------TPP--VVPANTTVPVAA 175
                             ||.:.|..||:..| |::|..|         :.|  .:|..||:....
Human  1431 TTYPTPSHPETTLPTHVPPFSTSLVTPSTHT-VITPTHAQMATSASNHSAPTGTIPPPTTLKATG 1494

  Fly   176 PVAAVPAAVPVVA---------------------------PVLAPAVAPAVAPVVAETPAPPPVA 213
            .....|...|..:                           |.:.|.....:.|....|....|||
Human  1495 STHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVA 1559

  Fly   214 EIPVATIPECVAPLIPEVSVVATKPLAAAEPVVVAPPATETPVVAPAAASPHVSV---APAVETA 275
            ....||......|.........:.|.::..|:...  :.:|....|..:.|..::   .|...|:
Human  1560 HTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTAT--SFKTTTTYPTPSHPQTTLPTHVPPFSTS 1622

  Fly   276 VVAP--------------VSAS-------TEPP------------VAAATLTTAPETPALAPV-V 306
            :|.|              .|||       |.||            ....||||:..:.||:.: .
Human  1623 LVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSLNT 1687

  Fly   307 AESQVA------------ANTVVATPPTPAPEPETIAPPVVAET--------------------- 338
            |::..:            |.:...|..||.| ..|..||:...|
Human  1688 AKTSTSLHSHTSSTHHAEATSTSTTNITPNP-TSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHS 1751

  Fly   339 -------PEVASVAVAETTP---------PVVPPVAAES--IP------APVVATTPVPATLAVT 379
                   |||.|.:....||         ||....:|.|  :|      :|...|||:.:|..||
Human  1752 HTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSPPTGTTPISSTGPVT 1816

  Fly   380 DPD---VTASAVPELPPVIAPSPVPSAVAETPVDLAPPVLPPVAAEPVPAVVAEETPETPAPASA 441
            ...   .|....|..|....|:.|||............|:.|...:...:......|....|  .
Human  1817 ATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGTIP--P 1879

  Fly   442 PVTIAALDIPEVAPVIAAPSDAPAEAPSAAAPIVSTPPTTASVP---ETTAPPAAVPTEPIDVSV 503
            |.||.|......||.:...:...:::||:    .||..|:.|:|   .:|..|...||...:::.
Human  1880 PTTIKATGSTHTAPPMTPTTSGTSQSPSS----FSTAKTSTSLPYHTSSTHHPEVTPTSTTNITP 1940

  Fly   504 L-SEAAIETPVAP---------PVEVTTEVAVADVAPPEAAADLIIEPVEPPAPIPDLLEQTTSV 558
            . :.....||||.         |...||.      :||..::     |.....|:.....|||:.
Human  1941 KHTSTGTRTPVAHTTSASSSRLPTPFTTH------SPPTGSS-----PFSSTGPMTATSFQTTTT 1994

  Fly   559 PAVEAAESTSSPIPETSLPPPNEAVASPEVAVAPITAPEPIPEPEPSLATPTEPIPVEAPVVIQE 623
            ....:...|:.|   |.:||.:.::.:|......||....:.......:|||..:|   |....:
Human  1995 YPTPSHPQTTLP---THVPPFSTSLVTPSTHTVIITTHTQMATSASIHSTPTGTVP---PPTTLK 2053

  Fly   624 AVDAVEV--PVTETSTSIPETTVEY----------------PVAEKVLDPAITEAPVTTQEPDVA 670
            |..:...  |:|.|::...:|...:                |.......|:   :|:|||.|.::
Human  2054 ATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSSRPPS---SPITTQLPHLS 2115

  Fly   671 NINDGAPATEITTPAVEIVTAAAEVSDTAIPLIDPPVPQEIAVAEIPETETKPAEVIVEQSTIPI 735
            :         .|||    |:...::|.:..|  .|..|..:: :.:|.:.:.|
Human  2116 S---------ATTP----VSTTNQLSSSFSP--SPSAPSTVS-SYVPSSHSSP------------ 2152

  Fly   736 EAPVPEVSKYAEPVISEAPAAEVPITAGD------NPDNTSVGISEVVPTIAEKAVEEVPTSEIP 794
            :...|.|...:..|  .||.....:::|.      :|...||..|.:.|  :..|......:.:|
Human  2153 QTSSPSVGTSSSFV--SAPVHSTTLSSGSHSSLSTHPTTASVSASPLFP--SSPAASTTIRATLP 2213

  Fly   795 EQSSSP---SDSVPVAKIT 810
            ...|||   |..:|::.:|
Human  2214 HTISSPFTLSALLPISTVT 2232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	51/246 (21%)
		rne	<109..300	CDD:236766	55/298 (18%)
		rne	<228..409	CDD:236766	56/277 (20%)
		rne	<331..594	CDD:236766	69/323 (21%)
		rne	<501..763	CDD:236766	54/289 (19%)
MUC6	NP_005952.2	VWD	40..192	CDD:214566
		C8	228..297	CDD:285899
		TIL	302..357	CDD:280072
		VWC_out	359..>403	CDD:214565
		VWD	386..549	CDD:214566
		C8	588..660	CDD:285899
		TIL	664..721	CDD:280072
		TIL	782..827	CDD:280072
		VWC	829..886	CDD:302663
		VWD	868..1017	CDD:278521
		C8	1057..1127	CDD:285899
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1455		47/218 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1471..1626		24/156 (15%)
		1, truncated	1561..1738		34/179 (19%)
		Approximate repeats	1607..1953		76/352 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1642..1834		43/192 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1983		29/131 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2077		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2090..2196		26/138 (19%)
		PHA03255	2188..>2343	CDD:165513	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2233..2278		214/1059 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2348
		CT	2351..2434	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900