DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpn and MUC5AC

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_001291288.1	Gene:	MUC5AC / 4586	HGNCID:	7515	Length:	5654	Species:	Homo sapiens

Alignment Length:	899	Identity:	221/899 - (24%)
Similarity:	321/899 - (35%)	Gaps:	163/899 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PV-SAPVAAPVTPSAVA-APVQVVSP------------------------AAVAPAPAAPIAVTP 47
            || |.||.||.|||..| :|.|..|.                        |......:||.|.|.
Human  2221 PVTSTPVTAPSTPSGRATSPTQSTSSWQKSRTTTLVTTSTTSTPQTSTTYAHTTSTTSAPTARTT 2285

  Fly    48 VAPPPTLASVQPATVT-----IPAPAPIAAASVAPVASV-APPVVAAPTPPAASPVSTPPVAVAQ 106
            .||.....|..||:.|     .|:|.|..:...||..|: :.|..:..:.|.:|..|.|....:.
Human  2286 SAPTTRTTSASPASTTSGPGNTPSPVPTTSTISAPTTSITSAPTTSTTSAPTSSTTSGPGTTPSP 2350

  Fly   107 IPVAVSAPVAPPVAATPTPVAPIPVAAPVIATPPVAASAPTPAAVTPVVSPVIATPPVVP----- 166
            :| ..|...||..:.|         :||..:|.....|:.|.|..|..:|....||..||
Human  2351 VP-TTSITSAPTTSTT---------SAPTTSTTSARTSSTTSATTTSRISGPETTPSPVPTTSTT 2405

  Fly   167 -ANTTVPVAAPVAAVPAAVPVVAPVLAPAVAPAVAPVVAETPAPPPVAEIPVATIPECVAPLIPE 230
             |.||...:||..:..:| |..:...:|..:...||..:.|..|..... ||.|.....||....
Human  2406 SATTTSTTSAPTTSTTSA-PTSSTTSSPQTSTTSAPTTSTTSGPGTTPS-PVPTTSTTSAPTTRT 2468

  Fly   231 VSVVATKPLAAAEPVVVAPPATETPVVAP---AAASPHVSV--APAVETAVVAPVS----ASTEP 286
            .|...:...:||.....:.|.| ||...|   ..:||..|.  ||...|...:..|    |.|.|
Human  2469 TSAPKSSTTSAATTSTTSGPET-TPRPVPTTSTTSSPTTSTTSAPTTSTTSASTTSTTSGAGTTP 2532

  Fly   287 -PVAAATLTTAPETPALAPVVAESQVAANTVVATPP--TPAPEPETIAPPVVAETPEVASVAVAE 348
             ||...:.|:||.|...:..::.:..|..|...:.|  ||:|.|.|    .....|..::.:...
Human  2533 SPVPTTSTTSAPTTSTTSAPISSTTSATTTSTTSGPGTTPSPVPTT----STTSAPTTSTTSGPG 2593

  Fly   349 TTPPVVPPVAAESIP------APVVATTPVPATLAVTDPDVTASAVPELP------------PVI 395
            |||..||..:..|.|      ||:.:||....|..::.|:.|.|.||...            |..
Human  2594 TTPSAVPTTSITSAPTTSTNSAPISSTTSATTTSRISGPETTPSPVPTASTTSASTTSTTSGPGT 2658

  Fly   396 APSPVPSAVAETPVDLAPPVLPPVAAEPVPAVVAEETPETPAPASAPVTIAALDIPEVAPVIAAP 460
            .|||||     |...::.|.....:|.......|..|..|..|.:.|..:      ......:||
Human  2659 TPSPVP-----TTSTISVPTTSTTSASTTSTTSASTTSTTSGPGTTPSPV------PTTSTTSAP 2712

  Fly   461 SDAPAEAPSA---AAPIVSTPPTTASVPETTAPPAAVPTEPIDVSVLSEAAIETPVAPPVEVTTE 522
            :.:...||:.   :||..||  |:|:...||:.|....|.....|.:|.:...|..|.....|:.
Human  2713 TTSTTSAPTTSTISAPTTST--TSATTTSTTSAPTPRRTSAPTTSTISASTTSTTSATTTSTTSA 2775

  Fly   523 VAVADVAPPEAAADLIIEPVEPPAPIPDLLEQTTSVPAVEAAESTSSPIPETSLPPPNEAVASPE 587
            ...:.::.|..:.               .|..|||..:.....:||:||..|:..|.....::|.
Human  2776 TTTSTISAPTTST---------------TLSPTTSTTSTTITSTTSAPISSTTSTPQTSTTSAPT 2825

  Fly   588 VAVAPITAPEPIPEPEPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTSIPETTVEYPVAEKV 652
            .:..  :.|.....|.|:.:|.:.|           .......|.|.| ||:|.::     ....
Human  2826 TSTT--SGPGTTSSPVPTTSTTSAP-----------TTSTTSAPTTRT-TSVPTSS-----TTST 2871

  Fly   653 LDPAITEAPVTTQEPDVANINDGAPATEITTPAVEIVTAAAEVSDTAIPLIDPPVPQEIAVAEIP 717
            ...:.|..|.||..|........||.|..|:......|:|...|.|:.|..........:...:|
Human  2872 ATTSTTSGPGTTPSPVPTTSTTSAPTTRTTSAPTTSTTSAPTTSTTSAPTSSTTSATTTSTISVP 2936

  Fly   718 ETETKPAEVIVEQSTIP--IEAPVPEVSKYAEPVISEAPAAEVPITAGDNPDNTSVGISEVVPTI 780
            .|.|         :::|  ..:|||..|..:.|..|...|:....|:|  |..|    ...|||.
Human  2937 TTST---------TSVPGTTPSPVPTTSTISVPTTSTTSASTTSTTSG--PGTT----PSPVPTT 2986

  Fly   781 AEKAVEEVPTSEIPEQS--SSPSDSVPVAKITPLLRDLQTTDVSLLAIAATLDA 832
            :..:.....|:..|..|  |:|:.|.|.|         .||..:|....:|..|
Human  2987 STTSAPTTSTTSAPTTSTISAPTTSTPSA---------PTTSTTLAPTTSTTSA 3031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	53/195 (27%)
		rne	<109..300	CDD:236766	56/206 (27%)
		rne	<228..409	CDD:236766	57/210 (27%)
		rne	<331..594	CDD:236766	63/283 (22%)
		rne	<501..763	CDD:236766	54/263 (21%)
MUC5AC	NP_001291288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..49
		VWD	74..216	CDD:214566
		C8	266..334	CDD:370094
		TIL	338..394	CDD:366828
		VWD	423..587	CDD:214566
		C8	624..694	CDD:214843
		TIL	704..761	CDD:366828
		TIL	802..863	CDD:366828
		VWD	892..1051	CDD:214566
		C8	1088..1162	CDD:214843
		PHA03247	<1335..1576	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1336..1377
		9 X Cys-rich subdomain repeats	1383..4731		221/899 (25%)
		Mucin2_WxxW	1389..1475	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1483..1575
		Mucin2_WxxW	1584..1670	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1688..1733
		Mucin2_WxxW	1749..1840	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1849..1948
		Mucin2_WxxW	1957..2043	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2059..2110
		Mucin2_WxxW	2122..2213	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2224..3214		219/896 (24%)
		107 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P	2257..3200		207/863 (24%)
		Mucin2_WxxW	3228..3319	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3329..3515
		17 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P	3363..3498
		Mucin2_WxxW	3526..3617	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3628..3951
		34 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P	3661..3931
		Mucin2_WxxW	3959..4050	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4060..4625
		58 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P	4093..4595
		Mucin2_WxxW	4633..4724	CDD:372569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4830..4849
		VWD	4911..5079	CDD:214566
		C8	5147..5205	CDD:370094
		VWC	5383..5447	CDD:327433
		CT	5534..5616	CDD:214482
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5622..5654
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900