DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpn and MUC1

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_001358649.1	Gene:	MUC1 / 4582	HGNCID:	7508	Length:	1230	Species:	Homo sapiens

Alignment Length:	930	Identity:	257/930 - (27%)
Similarity:	326/930 - (35%)	Gaps:	171/930 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEPGTIPS--------------PVSAPVAAPVTPSA---VAAPVQVVSPAAVAPAPAAPIAVTPV 48
            :.|.|.|:              ||:.|.....||.|   .:||....:|.:.|| ||..:...|.
Human    89 LAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTSAPDNKPAPGSTAP-PAHGVTSAPD 152

  Fly    49 APP------PTLASVQPATVTIPAPA----PIAAASVAPVASVAPPVVAAPTPPAASPVSTPPVA 103
            ..|      |....|..|..|.|||.    |....:.||....||...|.|.....|...|.|..
Human   153 TRPAPGSTAPQAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAP 217

  Fly   104 VAQIPVAVSAPVAPPVAATPTPVAPIPVAAPVIATPPVAASAPTPAAVTPVVSPVIATPPVVPA- 167
            .:..|.|.....||.  ..|.|.:..|.|..|.:.|.   :.|.|.:..|....|.:.|...||
Human   218 GSTAPAAHGVTSAPD--TRPAPGSTAPQAHGVTSAPD---TRPAPGSTAPPAHGVTSAPDTRPAP 277

  Fly   168 NTTVPVAAPVAAVPAAVPVVAPVLAPAVAPAVAPVVAETPAPPPVAEIPVATIPEC-VAP--LIP 229
            .:|.|.|..|.:.|...|.......||.....||.....|.....|...|.:.||. .||  ..|
Human   278 GSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPESRPAPGSTAPAAHGVTSAPESRPAPGSTAP 342

  Fly   230 EVSVVATKPLAAAEPVVVAPPA---TETPVVAPA---AASPHVSVAPAVETAVVAPVSASTEPPV 288
            ....|.:.|.:...|...||||   |..|...||   .|.|...|..|.:|   .|...||.||
Human   343 AAHGVTSAPESRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDT---RPAPGSTAPP- 403

  Fly   289 AAATLTTAPETPALAPVVAESQVAANTVVATPPTPAPEPETIAPPV--VAETPEVASVAVAETTP 351
             |..:|:||:|   .|....:...|:.|.:.|.| .|.|.:.|||.  |...|| :..|...|.|
Human   404 -AHGVTSAPDT---RPAPGSTAPPAHGVTSAPDT-RPAPGSTAPPAHGVTSAPE-SRPAPGSTAP 462

  Fly   352 PVVPPVAA-ESIPAPVVATTPVPATLAVTD-------PDVTASAVPEL--PPVIAPSPVPSAVAE 406
            |.....:| ||.|||   .:..||...||.       |..||.|...:  .|...|:|..:|...
Human   463 PAHGVTSAPESRPAP---GSTAPAAHGVTSAPESRPAPGSTAPAAHGVTSAPESRPAPGSTAPRA 524

  Fly   407 TPVDLAPPVLPPVAAEPVPAVVAEETPET-PAPAS-APVTIAALDIPEVAP-----------VIA 458
            ..|..||...|...:...||......|:| |||.| ||........|:..|           |.:
Human   525 HGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS 589

  Fly   459 APSDAPAEAPSAAAPI---VSTPPTTASVPETTAPPA-----AVPTEPIDVSVLSEAAIETPVAP 515
            ||...|  ||.:.||.   |::.|.|...|.:|||||     |..|.|...|          .||
Human   590 APDTRP--APGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS----------TAP 642

  Fly   516 PVE-VT----TEVAVADVAPPEAAADLIIEPVEPPAPIPDLLEQTTSVPAVEAAEST--SSPIPE 573
            |.. ||    |..|....||  ||..:...|...|||       .::.||.....|.  |.|.|.
Human   643 PAHGVTSAPDTRPAPGSTAP--AAHGVTSAPESRPAP-------GSTAPAAHGVTSAPESRPAPG 698

  Fly   574 TSLPPPNEAVASPEVAVAP-ITAP-------EPIPEPEPSLATP----------TEPIP-VEAPV 619
            ::.||.:...::|:...|| .|||       .|...|.|....|          |.|.| ..||.
Human   699 STAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPP 763

  Fly   620 V--IQEAVDAVEVPVTETS-----TSIPETTVEYPVAEKVLDPA--ITEAPVTTQEP-------- 667
            .  :..|.|....|.:...     ||.|:|.   |.......||  :|.||.|...|
Human   764 AHGVTSAPDTRPAPGSTAPPAHGVTSAPDTR---PAPGSTAPPAHGVTSAPDTRPAPGSTAPPAH 825

  Fly   668 DVANINDGAPATEITTPAVEIVTAAAEVSDTAIPLIDPPVPQEIAVAEIPETETKPAEVIVEQST 732
            .|.:..|..||...|.|....||:|.:..    |......|....|...|:|...|.......||
Human   826 GVTSAPDTRPAPGSTAPPAHGVTSAPDTR----PAPGSTAPPAHGVTSAPDTRRAPGSTPAPGST 886

  Fly   733 IPIEAPVPEVSKYAEPVISEAPAAEVPITAG--DNPDNTSVGISEVVP----TIAEKAVEEVPTS 791
            .|     |.....:.|....||.:..|...|  ..|||.....|...|    |.|..:.....::
Human   887 AP-----PAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTSASGSASGSAST 946

  Fly   792 EIPEQSSSPSDSVPVAKITP 811
            .:...:|:.:.:.|.:|.||
Human   947 LVHNGTSARATTTPASKSTP 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	47/170 (28%)
		rne	<109..300	CDD:236766	59/200 (30%)
		rne	<228..409	CDD:236766	62/198 (31%)
		rne	<331..594	CDD:236766	91/303 (30%)
		rne	<501..763	CDD:236766	77/304 (25%)
MUC1	NP_001358649.1	PRK07003	<92..437	CDD:235906	101/359 (28%)
		PHA03247	<276..826	CDD:223021	170/586 (29%)
		PRK12323	<758..982	CDD:237057	53/221 (24%)
		SEA	1009..1127	CDD:214554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000