DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpn and OTOG

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_001264198.1	Gene:	OTOG / 340990	HGNCID:	8516	Length:	2925	Species:	Homo sapiens

Alignment Length:	723	Identity:	179/723 - (24%)
Similarity:	264/723 - (36%)	Gaps:	135/723 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ASVQPATVTIPAPAPIAAASVAPVASVAPPVVAAPTPPAASPVSTPPVAVAQ-------IPV-AV 111
            |...|...|...|   .|||...|..|...|...|||.....|:...|.:..       :|. |:
Human  1415 ACASPCFQTCRDP---RAASCRDVPRVEGCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEAL 1476

  Fly   112 SAPVAPPVAATPTPVAPIPVAAPVIATPPVAASAPTPAA--VTPVVSPVIAT--PPVVPANTTVP 172
            .....||....|||....|..:......|....|.||||  .|.:..||.||  |.|.|..|...
Human  1477 GNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTT 1541

  Fly   173 VAAPVAAVPAAVPVVAPVLAPAVAPAVAPVVAETPAPPPVAEIPVATIPECVAPLIPEVSVVATK 237
            :..|:....:.:| ..|..:||.....|.::| .|..|..:.:|||
Human  1542 LQQPLELTASQLP-AGPTESPASKGVTASLLA-IPHTPESSSLPVA------------------- 1585

  Fly   238 PLAAAEPVVVAPPATETPVVAPAAASPHVSVAPAVETAVVAPV--SASTEPPVAAATLTTAPETP 300
             |....|.:|:.....|.|....|.||:::|:.....|...|:  .|.|.....:..:.|.|..|
Human  1586 -LQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQP 1649

  Fly   301 ALAPVVAESQVAANTVVATPPTPAPEPETIAPPVVAET--------PEVASVAVAETTPPVVPPV 357
            :|....:...||:...::..||.:...:.:..|.|.:.        |..|..|.:.:||..|...
Human  1650 SLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGT 1714

  Fly   358 AAESIPAPVVATTPVPATLAVTDPDVTASAVPELPPVIAPSPVPSA----VAETPVDLAPPVLPP 418
            |||.:|...:||..:...|:....:...|.....|....|.|:|||    ...|.:....|.||
Human  1715 AAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP- 1778

  Fly   419 VAAEPVPAVVAEETPETPAPASAPVTIAALDIPEVAPVIAAPSDAPAEAPSAAAPIVSTP----P 479
                          |||||.||..   .|.|.....|.::..|..|::..|...|..|.|    .
Human  1779 --------------PETPAAASLS---TATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVG 1826

  Fly   480 TTASVPETTAPPAAVPTEPIDVSVLS-EAAIETPVAP--PVEVTTEVAVADVAPPEA--AADLII 539
            |:|.| .|..|.|:|.|.|:.....: .|...:||.|  |..:|.......:|||.|  |..|::
Human  1827 TSAPV-ATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLL 1890

  Fly   540 EPVEPPAPIPDLLEQTTSVPAVEAAESTSSPI----PETSLPP---------PNEAVASPEVAVA 591
            ....|.:.:..:.|.|.|:.:|...:||:..:    .:.|||.         |.|...:....:.
Human  1891 GATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLT 1955

  Fly   592 PITAPEPIPEPEPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTSIPETTVEYPVAEKVLDPA 656
            |:.|     |||.:.|....|:|.      ..|:..|      ::.:.|:.::      .||.|.
Human  1956 PLVA-----EPEGAQAGTALPVPT------SYALSRV------SARTAPQDSM------LVLLPQ 1997

  Fly   657 ITEAPVTTQEPDVANINDGAPATEITT-------PAVEIV---------TAAAEVSDTAIPLIDP 705
            :.||..|:..|.:|    ..|..|.||       ||:.||         |..|..|.|.:|:.:.
Human  1998 LAEAHGTSAGPHLA----AEPVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ 2058

  Fly   706 PVPQEIAV 713
            ...:.|.:
Human  2059 DCVRHICL 2066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	36/123 (29%)
		rne	<109..300	CDD:236766	49/197 (25%)
		rne	<228..409	CDD:236766	44/194 (23%)
		rne	<331..594	CDD:236766	76/296 (26%)
		rne	<501..763	CDD:236766	57/247 (23%)
OTOG	NP_001264198.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..69
		VWD	152..302	CDD:278521
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..335
		C8	348..412	CDD:285899
		TIL	426..474	CDD:280072
		VWC_out	476..>511	CDD:214565
		VWD	503..668	CDD:214566
		C8	711..770	CDD:285899
		TIL	780..844	CDD:280072
		TIL	884..946	CDD:280072
		VWD	977..1131	CDD:214566
		C8	1166..1240	CDD:214843
		Fascin	<1305..>1370	CDD:304938
		DUF4696	1473..1987	CDD:292395	140/571 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1476..1540		21/63 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1636..1679		8/42 (19%)
		E_Pc_C	<1639..1720	CDD:284226	19/80 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1693..1715		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1737..1788		18/65 (28%)
		HrpB2	1953..>2040	CDD:305050	27/113 (24%)
		VWD	2112..2266	CDD:278521
		C8	2304..2370	CDD:214843
		TIL	2373..2434	CDD:280072
		NADB_Rossmann	<2676..2736	CDD:304358
		CT	2842..2924	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900