DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpn and Sspo

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	XP_017177063.1	Gene:	Sspo / 243369	MGIID:	2674311	Length:	5197	Species:	Mus musculus

Alignment Length:	467	Identity:	100/467 - (21%)
Similarity:	149/467 - (31%)	Gaps:	117/467 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 AVPAAVPVVAPVLAPAVAPAVAP---VVAE--TPAPPPVAEIPVATIPECVAPLIPEVSVVATKP 238
            |:|.....|..:..||.|||.||   :.|.  |...||.|:       .|.:||     .:|..|
Mouse  2065 ALPEKNQTVIHMTTPAPAPASAPSPQIGAHLVTYVLPPTAD-------ACYSPL-----GLAGLP 2117

  Fly   239 LAAA----EPVVVAPPATETPVVAP-----AAASPHVSV--------APAVETAVVAPVSASTEP 286
            :.|.    |.:..|.| .|.|:..|     |:|..|...        .|...|.::...:.|:..
Mouse  2118 MWAPSQHWEHITRADP-VEAPMAGPGPREGASAEWHTQPLYLQLDLRRPRNLTGIIVQRAGSSAA 2181

  Fly   287 PVAAATLTTAPETPALAPVVAESQVAANTVVATPPTPAPEPETIAPPVVAETPEVASVAVAETTP 351
            .|:..:|..:.:.     :...:.|.:.:...:||.|:||......|.|....::
Mouse  2182 YVSTLSLQFSSDN-----LQWHNYVNSLSSTLSPPKPSPESSNHMAPEVWTFDQM---------- 2231

  Fly   352 PVVPPVAAESIPAPVVATTPVPATLAVTDP-DV---------TASAVPELPPVIAPSPVPSAVAE 406
                      :.|..:...|....|...:. |:         ....|..|.|:...|....|..|
Mouse  2232 ----------VQARYIRVWPHSGHLRDNNQHDIFLWVELLGCKPGTVSPLAPLCPGSRHRCASGE 2286

  Fly   407 T-----PVDLAPPVLPPVAAEPVPAVVAEET----PETPAPASAPVTIAALDIPEVAPVIAAPSD 462
            .     |.|.|.........|...::.|..|    |.|..||.:|..      |...|....|..
Mouse  2287 CAPKGGPCDGAVDCDDGSDEEGCGSLHASTTSRVHPMTRTPALSPTQ------PGKFPREGLPDT 2345

  Fly   463 AP------AEAPSAAAPIVSTPPTTASVPETTAPPAAVPTEPIDVSVLSEAAIETPVAPPVEVTT 521
            .|      :..|.|..|:.:...|      :|.||.|....|      ..||:  .|.||..||.
Mouse  2346 EPQQPKQESSLPGAGQPMQTLSAT------STFPPGAKSLHP------GMAAV--TVHPPHSVTP 2396

  Fly   522 EVAVADVAPPEAAADLIIEPVEPPAPIPDLLEQTTSVPAVE----------AAESTSSPIPETSL 576
            ...|.....|.....:...|.:.|..:...:||.......|          .|.:....:|.|:|
Mouse  2397 GAPVGQTVSPRPFPPMPCGPGQVPCDVLGCVEQEQLCDGREDCLDGSDEQHCASAEPFTVPTTAL 2461

  Fly   577 P--PPNEAVASP 586
            |  |.::|:.||
Mouse  2462 PGLPASKALCSP 2473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766
		rne	<109..300	CDD:236766	35/142 (25%)
		rne	<228..409	CDD:236766	35/212 (17%)
		rne	<331..594	CDD:236766	59/293 (20%)
		rne	<501..763	CDD:236766	23/98 (23%)
Sspo	XP_017177063.1	VWD	229..378	CDD:214566
		C8	434..505	CDD:370094
		TIL	509..564	CDD:366828
		VWD	593..753	CDD:214566
		C8	791..863	CDD:214843
		TIL	866..919	CDD:366828
		VWD	1054..1201	CDD:365869
		C8	1245..1311	CDD:370094
		TIL	1315..1371	CDD:366828
		LDLa	1416..1451	CDD:238060
		LDLa	1456..1490	CDD:238060
		LDLa	1492..1526	CDD:238060
		LDLa	1532..1563	CDD:197566
		Ldl_recept_a	1603..1639	CDD:365841
		TSP1	1737..1788	CDD:214559
		TIL	1857..1908	CDD:366828
		TSP1	1952..2005	CDD:214559
		FA58C	<2142..2262	CDD:330301	20/144 (14%)
		LDLa	2275..2309	CDD:238060	7/33 (21%)
		LDLa	2414..2448	CDD:238060	5/33 (15%)
		LDLa	2471..2505	CDD:238060	2/3 (67%)
		TSP1	2565..2617	CDD:214559
		TIL	2640..2682	CDD:366828
		TSP1	2725..2774	CDD:214559
		TSP_1	2841..2889	CDD:365867
		TIL	2893..2952	CDD:366828
		VWC_out	2954..3001	CDD:214565
		TSP1	2994..3045	CDD:214559
		TIL	3097..3149	CDD:366828
		TSP1	3193..3256	CDD:214559
		TSP1	3262..3314	CDD:214559
		TIL	3322..3372	CDD:366828
		TSP1	3418..>3458	CDD:214559
		TSP1	3482..3526	CDD:214559
		TIL	3536..3592	CDD:366828
		TSP1	3655..3699	CDD:214559
		TSP1	3832..3884	CDD:214559
		TSP1	3901..3949	CDD:214559
		TSP1	3967..4020	CDD:214559
		TSP1	4025..4077	CDD:214559
		TIL	4080..4135	CDD:366828
		TSP1	4180..4230	CDD:214559
		TSP1	4274..4325	CDD:214559
		TSP1	4389..4440	CDD:214559
		TIL	4444..4499	CDD:366828
		TSP1	4639..4687	CDD:214559
		TIL	4701..4747	CDD:366828
		TSP1	4791..4840	CDD:214559
		TIL	4842..4896	CDD:366828
		TIL	4948..5006	CDD:366828
		VWC	5008..5063	CDD:327433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900