DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cpn and VWCE

DIOPT Version :9

Sequence 1:NP_731674.1 Gene:Cpn / 41474 FlyBaseID:FBgn0261714 Length:864 Species:Drosophila melanogaster
Sequence 2:NP_689931.2 Gene:VWCE / 220001 HGNCID:26487 Length:955 Species:Homo sapiens


Alignment Length:760 Identity:155/760 - (20%)
Similarity:229/760 - (30%) Gaps:269/760 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 VAAPVTPSAVAAPVQVVSP-------AAVAPAPAAPIAVTPVAPPPTLASVQPA---TVTIPAPA 68
            |:....|.||.||..::.|       ..:.|....| |::|...||:.|...||   |..:|:|.
Human   259 VSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRP-ALSPGHSPPSGAPGPPAGVRTTRLPSPT 322

  Fly    69 PIAAASVAPVASVAPPV------VAAPTPPAASPVSTPPVAVAQ-----IPVAVSAPVAPPVAAT 122
            |     ..|.:|.:.||      :|.|.|.|:...:..|.::.|     .|.:...|.:|.:||.
Human   323 P-----RLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAG 382

  Fly   123 PTPVAPIPVAAPVIA--TPP--------------------VAASAPTP---------------AA 150
            |:|...:.......:  |.|                    .|.|.|.|               :.
Human   383 PSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSG 447

  Fly   151 VTPVVSPVIATPPVVPANTTVPVAAPVAAVPAAVPVVAPVLAPAVAPAVAPVVAETPAPPPVAEI 215
            |......|.:.|   ..|.||.|                    .:|..|:.:..|.|:.|     
Human   448 VVRAEGDVFSPP---NENCTVCV--------------------CLAGNVSCISPECPSGP----- 484

  Fly   216 PVATIPECVAPLIPEVSVVATKPLAA-------AEPVVVAPPATETPVVAPAAASPHVSVAPAVE 273
                   |..|  |:.......|:..       |:..|.:....|.............|..|..|
Human   485 -------CQTP--PQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE 540

  Fly   274 TAV------VAP---VSASTEP-PVAAATLTT-----------APETPA-LAPVVAESQVAANTV 316
            .|.      :.|   .....|| |....:|..           :|..|. |....|:..|:....
Human   541 LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRT 605

  Fly   317 --VATPPTPAPEPETIAPPVVAETPEVASVAV-AETTPPVVPP----------VAAESIPAPVVA 368
              |.:.|.|...|....|...|.......:.. .||.|.|:.|          ||...:..|:..
Human   606 DCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITC 670

  Fly   369 TTP------------------------------------------------VPATLAVTDP---- 381
            |.|                                                ||...|..||    
Human   671 TYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLP 735

  Fly   382 -DVTASAVPELPPV-----------IAPSPVPSAV---AETPVDLAPPVLPPVAAEPVPA----- 426
             |..:|....|.|:           :|.|....::   .|.||:.:....||.|:...|.     
Human   736 GDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHLLQ 800

  Fly   427 -------VVAEETPETPAPASAPVTIAALDIPEVAPVIAAPSDAPAEAPSAAAPIVSTPPTTASV 484
                   :..:..|.:||.|..|.::|          :...:..|.|  ..|:|.:|..|:|   
Human   801 LLLRTNLMKTQTLPTSPAGAHGPHSLA----------LGLTATFPGE--PGASPRLSPGPST--- 850

  Fly   485 PETTAPPAAVPTEPIDVSVLSEAAIETPVAPPV--EVTTEVAVADVA---PP-------EAAADL 537
                 ||.| ||.|:       |:...|..|||  |.:...:.|.:.   ||       ||:|..
Human   851 -----PPGA-PTLPL-------ASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALS 902

  Fly   538 IIEPVEPPAPI----PDLLEQTTSVPAVEAAESTSSPIPETSLPP 578
            :::|.....||    |.:|..|||..:. |..:|:.|.|:.  ||
Human   903 MMDPSPSKTPITLLGPRVLSPTTSRLST-ALAATTHPGPQQ--PP 944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CpnNP_731674.1 rne <9..167 CDD:236766 46/210 (22%)
rne <109..300 CDD:236766 41/255 (16%)
rne <228..409 CDD:236766 47/289 (16%)
rne <331..594 CDD:236766 75/354 (21%)
rne <501..763 CDD:236766 26/94 (28%)
VWCENP_689931.2 EGF_CA 142..180 CDD:214542
cEGF 200..223 CDD:315355
EGF_CA 220..262 CDD:214542 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..329 13/42 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..380 4/19 (21%)
VWC 386..440 CDD:327433 6/53 (11%)
VWC 501..559 CDD:327433 8/57 (14%)
VWC 572..625 CDD:214564 10/52 (19%)
VWC 629..684 CDD:327433 10/54 (19%)
VWC 687..742 CDD:327433 6/54 (11%)
Atrophin-1 <726..944 CDD:331285 59/248 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 812..889 26/104 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..955 14/45 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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