DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpn and R11G1.1

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_001361923.1	Gene:	R11G1.1 / 187815	WormBaseID:	WBGene00020010	Length:	1745	Species:	Caenorhabditis elegans

Alignment Length:	845	Identity:	168/845 - (19%)
Similarity:	264/845 - (31%)	Gaps:	352/845 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 ETPVVAPAAAS-----------PHV----------------SVAPAVETAVVAPVSASTEPPVAA 290
            :|.||...||.           ||:                |||.|...|.......| .||..:
Worm   902 QTVVVGQKAAKSLEMDGNREKLPHMKAIFAESLKHSAKGSTSVASAFALADFKRKKVS-RPPDMS 965

  Fly   291 ATLTTAPETP--------ALAPVVAESQVAANTVVATPPTPAPEPETIAPPVVAETPEVASVAVA 347
            ..:....|.|        :|..|.:.::::.:|..:.||||....||   |::.:.....|:..|
Worm   966 QVIEEVNENPTASIHNSESLPKVSSLAKISTHTANSEPPTPVGVIET---PILEKNSSSVSLVSA 1027

  Fly   348 ETTPPVVPPVAAESIPAPVVATTPVPATLAVTDPDVT----------------ASA----VPE-- 390
            ....|.:|     |:|.|:    |||.|.:.:..::.                |||    |||
Worm  1028 NDNAPQLP-----SLPLPL----PVPITTSASTTNLEETTGKENGREGGGGSHASAQEQQVPETE 1083

  Fly   391 ---------LPPVI------------------APSPVPS-------AVAETPVDLAPPVLPPV-- 419
                     :.|.|                  ..:.|.|       .:|||  ......:|.|
Worm  1084 RPASSHSVGVQPTIWETYRVLGQQYSKSDLTERKASVDSLEQMFEARLAET--SRTTKTIPTVRT 1146

  Fly   420 ----------AAEPV------PAVVAEETPETPAPASAPVTIAALDIPEVAPVIAAPSDA----- 463
                      .|:|.      |.:|:|||.:||            |..||.  :..|||.
Worm  1147 DKSDNSAIIFTAKPYKKDTEKPTLVSEETKKTP------------DNAEVN--LEKPSDTTQDIK 1197

  Fly   464 ----------PAEAPSAAAPIVST----PPTTASVPETTAPPAAV-------------PT--EPI 499
                      ..|..|..|.::..    .|.|.|.|::....|.|             ||  :.:
Worm  1198 QNLEEQKETDEKETDSKLADMIGVTSFHKPDTPSRPDSGKKDAKVIPKTGQVESEPYSPTLEKSL 1262

  Fly   500 DVSVLSEAA---IETPVAP--PVEVTTEV---AVADVAPPEAAADLIIEPVEPPAP--------- 547
            :.::|.|.|   ||.|::|  |:.:.||:   |.|:.|..|.:.|..::|.:|..|
Worm  1263 EAALLIEMAKRGIELPLSPKTPIPIATELEKAASANFATAETSEDSEVKPYQPQTPKKPESRKSS 1327

  Fly   548 -----------IPDLLEQTTSVPAVEAAESTSSPIPETSLPPP---------------------- 579
                       ||     :||...|.:|:...|.|.|....|.
Worm  1328 AKSSASSKRSKIP-----STSQSRVGSAKKQISQIDEQDKEPDVFVPQGAKAIYQTKRILRRSGG 1387

  Fly   580 ----NEAVAS-----PEVA----------------VAPITAPEPIPEPEPSLATPTEPIPVEAPV 619
                ||.|.|     ||||                ..|........:||.:|::.:|.   .|.:
Worm  1388 AGGVNELVPSTDESDPEVAFFKKLDRIKQDSRNYPAHPYRKYSRRRKPERTLSSISEK---SAEI 1449

  Fly   620 VIQEAVDAVEVPVTETSTSIPETTVEYPVAEKVLDPAITEAPVTTQEPDVANINDGAPATEITTP 684
            ..:.|:|..:    :||.|.|.||..:      |:|..:.||....:.
Worm  1450 AAEAALDYPQ----DTSISCPATTRTF------LEPRFSMAPRYVFKR----------------- 1487

  Fly   685 AVEIVTAAAEVSDTAIPLIDPP--VPQEIAVAEIPETETKPAEVIVE--QSTIPIEAPVPEV--- 742
              ::|.|:.|.||..:|.:.|.  .|..::..|||:...:.:...:.  :|.:..:.|.|:.
Worm  1488 --KVVEASEETSDVDMPRLSPARHAPPVVSSPEIPDVSLQRSMENLHKLESKVKPQPPYPQTPTK 1550

  Fly   743 -----------------------------SKYAE----PVISEA-PAA----------------- 756
                                         ||:|.    |...:| ||:
Worm  1551 KSNLMKKKTGKNESSASHPSSSLQSSRHSSKFASKATTPRTGDATPASMTSRSTRHSVISRKIAI 1615

  Fly   757 ---EVPITAGDNPDNTSVGISEVVPTIAEKAVEEV-------PTSEIPEQSSSPSDSVPVAKITP 811
               |:....|...|.:...:..|:||.:.:..:.|       |..:|.....:|..|..:..|||
Worm  1616 RRQELKAVTGSARDLSGSRVDRVIPTHSLRGAKSVGDLSKRQPNWDISPYRDTPGPSSFLPPITP 1680

Fly 812 811
Worm 1681 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766
		rne	<109..300	CDD:236766	16/73 (22%)
		rne	<228..409	CDD:236766	51/246 (21%)
		rne	<331..594	CDD:236766	90/445 (20%)
		rne	<501..763	CDD:236766	76/397 (19%)
R11G1.1	NP_001361923.1	LDLa	32..64	CDD:197566
		LDLa	113..145	CDD:238060
		PHA03247	<268..594	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900