DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpn and Otog

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	XP_017177514.1	Gene:	Otog / 18419	MGIID:	1202064	Length:	2917	Species:	Mus musculus

Alignment Length:	768	Identity:	184/768 - (23%)
Similarity:	275/768 - (35%)	Gaps:	193/768 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PVAP-PPTLASVQPATVTIP---APAPIAAASVAPVASVAPPVVAAPTPPAASPVSTPPVAVAQI 107
            ||.| |..|..|....|.:.   .|||..........::.|..|    ||..|       |..|:
Mouse  1436 PVCPTPKVLDEVTQRCVYLEDCVEPAPRGPTETLGNETLVPGQV----PPTTS-------AEQQL 1489

  Fly   108 PVAVSAPVAPPVAATPTPVAPIPVAAPVIATPPVAAS---APTPAAVTPVV-SPVIATPPVVPAN 168
            |..:  |.|...:..|.|||| |.:||   .||:||:   ||:|.:..|.: :|:..|....||.
Mouse  1490 PQGL--PGASAYSPAPVPVAP-PTSAP---NPPMAATEGQAPSPGSTQPTLQTPLGLTTSNFPAG 1548

  Fly   169 TTVPVAAPVAAVPAAVPVVAPVLAPAVAPAVAPVVAETPAPPPVAEIPVATIPECVAPLIPEVSV 233
            .|...|....|        |.:|.             |..||..:    :::|..:.  :|...:
Mouse  1549 HTEATAREEGA--------ASLLT-------------TSHPPGFS----SSLPSSLQ--MPTSGI 1586

  Fly   234 VATKPLAAAEPVVVAPPATETPVVAPAAASPHVSVAPAVETAVVAPVSASTEPPVAAATLTTAPE 298
            |:    .|.|...|....|.:|....|:.||.:...|.:..||..| |..:.|      :.|.|.
Mouse  1587 VS----GATETTKVTITFTGSPNTTVASRSPPIPRFPLMTKAVTVP-SHDSFP------VKTTPL 1640

  Fly   299 TPALAPVVAESQVAANTVVATPPT-PAPEPETIAPPVVAETPEVASV---AVAETTPPVVPPVAA 359
            .|:....::...:.:....:.||| |.....|....|..:|....||   :.:.::.|:.....|
Mouse  1641 QPSWLWSLSSRPMTSLGATSWPPTSPGSHLSTAVTKVANKTMTSLSVLAQSTSSSSQPLAAVTTA 1705

  Fly   360 ESIPAPVVATTPVPATLAVTDPDVTASAVPELPPVIAPSPVPSAVAETPVDLAPPVLPPVAAEPV 424
            ...||..:.|..:....|....:...|.:.|||  ::|.|.|:     |:||..|
Mouse  1706 HRAPASPLVTKGLEVVSATEKGEAGHSQLTELP--VSPPPSPA-----PIDLPHP---------- 1753

  Fly   425 PAVVAEETPETPAP-ASAPVTIAALDIPEVAPVIAAPSDAPAEAPSAAAPIVSTPPTTASVPETT 488
                |:.|...|.| |.:|..:||          .:||.. |..|.|.|        .||: |.|
Mouse  1754 ----AQHTTTAPGPSALSPGILAA----------GSPSTG-AHRPGATA--------LASL-EPT 1794

  Fly   489 APPAAVPTEPIDVSV-LSEAAIETPVA-----------PPVEVTTEVAVADVAPPEAAADLIIEP 541
            .||..:...|:|.|: |::.....|||           ||....|.:|.|....|
Mouse  1795 RPPHLLSGLPLDTSLPLAKVGTSAPVATPGSKGYIPTPPPQHQATTLATAMTVSP---------- 1849

  Fly   542 VEPPAPIPDLLEQTTS--VPAVEAAESTS-SPIPETSLPPPNEAVASPEVAVAPIT---APEPIP 600
                      |.|:.|  ||.:.|.|..: ||.|:   ||....:|..::..|.:.   |...|.
Mouse  1850 ----------LTQSLSLTVPLMSAVEEQAHSPSPK---PPQGTGMAPDQMLGATLPSFGASSVIA 1901

  Fly   601 EPEPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTSIPETTVEY-PVAEKVLDPAITEAPVTT 664
            ...|:::........:...::.:.|.    |.|..|.|:.....|. |:....:.|..|||
Mouse  1902 GVPPTVSAAPRKSTTQRAAILSKKVS----PPTLISDSVQGGFTELTPIVSHTVTPLATEA---- 1958

  Fly   665 QEPDVANINDGAPATEITTPAVEIVTAAAEVSDTAI----PLIDPPVPQEIAVAEIPETETKPAE 725
                     :|..|.  |.|.|....:.:.||....    ||:..|   ::|.|.......:|.|
Mouse  1959 ---------EGPRAG--TVPLVPTTYSLSRVSARTASREGPLVLLP---QLAEAYGTPAGLQPQE 2009

  Fly   726 VIVEQSTIP---IEAPVPEVSKYAEPVISEAPAAEVPITAGDNPDNTSVGISE 775
            .:|.|:|..   ..||       |:.:..|:..|||      |...|.|.|:|
Mouse  2010 DLVRQATTEQSGRSAP-------AKSIAEESMEAEV------NTSATCVPIAE 2049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766	38/127 (30%)
		rne	<109..300	CDD:236766	49/194 (25%)
		rne	<228..409	CDD:236766	41/184 (22%)
		rne	<331..594	CDD:236766	68/281 (24%)
		rne	<501..763	CDD:236766	63/287 (22%)
Otog	XP_017177514.1	VWD	145..292	CDD:365869
		C8	343..405	CDD:370094
		TIL	420..467	CDD:366828
		VWC	469..>504	CDD:327433
		VWD	507..659	CDD:365869
		C8	706..765	CDD:370094
		TIL	773..837	CDD:366828
		TIL	877..939	CDD:366828
		VWD	970..1124	CDD:214566
		C8	1159..1233	CDD:214843
		Fascin	<1298..1389	CDD:390083
		PHA03247	<1459..1974	CDD:223021	153/652 (23%)
		VWD	2104..2256	CDD:365869
		C8	2294..2362	CDD:214843
		TIL	2365..2426	CDD:366828
		CT	2834..2916	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900