DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpn and Nefm

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_032717.2	Gene:	Nefm / 18040	MGIID:	97314	Length:	848	Species:	Mus musculus

Alignment Length:	317	Identity:	69/317 - (21%)
Similarity:	107/317 - (33%)	Gaps:	65/317 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 PPVEVTTEVAVADV-APPEAAADLIIEPVEPPAPIPD---LLEQTTSVPAVEAAESTSSPIPETS 575
            |.|.:::::....| ||........:|.:.....:.|   .:|:|.:..|.|.|.|......|.
Mouse   427 PSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEA- 490

  Fly   576 LPPPNEAVASPEVAVAPITAPEPIPEPEPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTSIP 640
                .|....||...:|:.:||...|.|.......|    |.....:|..:.|:....|...|..
Mouse   491 ----EEKEEEPEAEKSPVKSPEAKEEEEEGEKEEEE----EGQEEEEEEDEGVKSDQAEEGGSEK 547

  Fly   641 ETTVEYPVAEKVLDPAITEAPVTTQEPDVANINDGAPATEITTPAVEIVTAAAEVSDTAIPLIDP 705
            |.:.|....|:..:...|||....:|.:                |.|......:|.:.|
Mouse   548 EGSSEKDEGEQEEEEGETEAEGEGEEAE----------------AKEEKKIEGKVEEVA------ 590

  Fly   706 PVPQEIAVAEIPETETKPAEVIVEQSTIPIEAPVPE-------------VSKYAEPVISEAPAAE 757
             |.:||.| |.||....|    :.:|.:....|.||             |.:..:.|..|:|..|
Mouse   591 -VKEEIKV-EKPEKAKSP----MPKSPVEEVKPKPEAKAGKGEHKEEEKVEEEKKEVTKESPKEE 649

  Fly   758 VPITAGDNPDNTSVGISEVVPTIAEKAVEEVPT----------SEIPEQSSSPSDSV 804
            ......:.|.:.:.......| :.|||||||.|          .:..|:...|.:.|
Mouse   650 KVEKKEEKPKDVADKKKAESP-VKEKAVEEVITISKSVKVSLEKDTKEEKLQPQEKV 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766
		rne	<109..300	CDD:236766
		rne	<228..409	CDD:236766
		rne	<331..594	CDD:236766	18/82 (22%)
		rne	<501..763	CDD:236766	56/264 (21%)
Nefm	NP_032717.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Head	2..102
		Filament_head	10..97	CDD:282575
		Filament	98..409	CDD:278467
		Coil 1A	103..134
		Linker 1	135..147
		Coil 1B	148..246
		Linker 12	247..263
		Coil 2A	264..285
		Linker 2	286..289
		Coil 2B	290..410
		Tail	411..848		69/317 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..785		57/262 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900