DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpn and Vwf

DIOPT Version :9

Sequence 1:	NP_731674.1	Gene:	Cpn / 41474	FlyBaseID:	FBgn0261714	Length:	864	Species:	Drosophila melanogaster
Sequence 2:	NP_446341.1	Gene:	Vwf / 116669	RGDID:	621759	Length:	2812	Species:	Rattus norvegicus

Alignment Length:	775	Identity:	167/775 - (21%)
Similarity:	258/775 - (33%)	Gaps:	231/775 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 APAVAPVVAETPAPPPVAEIPVATIPECVAPLIP-----------------EVSVVATKPLAAAE 243
            ||| .||..:.|.|   ...||..:..|.|...|                 .|..||.:.||:.:
  Rat  1150 APA-CPVTCQHPEP---LACPVQCVEGCHAHCPPGKILDELLQTCVDAQDCPVCEVAGRRLASGK 1210

  Fly   244 PVVVAPPATE---------TPVVAPAAASPHVSVAPAVETAVVAPVSASTEPPVAAATLTTAPET 299
            .:.::|...:         ..:...|...|...|.|..:    ||||::|  |....|    ||.
  Rat  1211 KITLSPNDPQHCQNCHCDGVNLTCEACQEPGGLVVPPTD----APVSSTT--PYVEDT----PEP 1265

  Fly   300 P-------ALAPVV-----------AESQVAANTVVATPPTPAPEPETIAPPVVAETPEVASVAV 346
            |       .|..:|           ||.:|....||.|........:.|...|| |..:.:...:
  Rat  1266 PLHNFYCSKLLDLVFLLDGSYRLSEAEFEVLKAFVVGTMERLHISQKRIRVAVV-EYHDGSHAYL 1329

  Fly   347 ---AETTPPVVPPVAAE--SIPAPVVATTPV-PATL-----AVTDPDVTASAVPELPPVIAPSPV 400
               |...|..:..:|::  .:.:.:.:|:.| ..||     .:..|:  ||.|..|   :..|..
  Rat  1330 ELRARKRPSELRRIASQIKYVGSQLASTSEVLKYTLFQIFGKIDRPE--ASRVILL---LTASQE 1389

  Fly   401 PSAVA-----------ETPVDLAPPVLPPVAAEPVPAVVAEETPETPAPASAPVTIAALDIPEVA 454
            |..:|           :..|.|.|..:.|.|......::.::.||..|     ..::.:|..|..
  Rat  1390 PQRMARYFTRYLQGFKKKKVILIPVGIGPHANLKQIRLIEKQAPENKA-----FLLSGVDELEQR 1449

  Fly   455 --PVIAAPSDAPAEAPSAAAPIVSTPPTTASVPETTAPPAAVPTEP--------IDVSVLSEAAI 509
              .:|....|.   ||.|.||  :.||..|.:  |.:|..:..:.|        :||..:.||:.
  Rat  1450 RDEIINYLCDL---APEAPAP--TKPPQVAHI--TVSPGISGVSSPGPKRKSLVLDVVFVLEASD 1507

  Fly   510 ETPVA---PPVEVTTEVAV-ADVAPPEAAADLIIEPVEPPAPI----------PDLL-------- 552
            |...|   ...|...||.. .||:|  |...:.:........:          .|:|
  Rat  1508 EVGEANFNKSKEFLEEVIQRMDVSP--AGTHIAVLQYSYTVNVEYTFKEAQSKEDVLRHVREIRY 1570

  Fly   553 ---EQTTSVPAVE-AAESTSSP-------IPE-----TSLPPPNEAVASP-EVAVAPITAP---- 596
               .:|.:..|:: .:|.:.||       .|.     |..|..:|....| ::.|.||...
  Rat  1571 QGGNRTNTGQALQYLSEHSFSPSQGDREQAPNLVYMVTGNPASDEIRRLPGDIQVVPIGVGSRAN 1635

  Fly   597 ----EPIPEP-EPSLATPTEPIPVEAPVVIQEAVDAVEVPVTETSTSIPETTVEYPVAEKVLDPA 656
                |.|..| .|......|.:|.|||.:           |..|..|          .|.:..|.
  Rat  1636 LQELERISRPIAPIFIQDFETLPREAPDL-----------VLRTCCS----------KEGLQLPT 1679

  Fly   657 ITEAPVTTQEPDVANINDGA---PAT---EITTPAVEIV---------TAAAEVSDTAIPLIDPP 706
            :...|..:|..||..:.||:   ||:   |:.:.|...:         |..:.:...:|..||.|
  Rat  1680 LPPLPDCSQPLDVVLLLDGSSSLPASSFDEMKSFAKAFISKANIGPHLTQVSVIQYGSINTIDVP 1744

  Fly   707 --VPQEIA----VAEIPETETKPAEV------IVEQSTIPIEAPVPEVSKYAEPVISEAP----- 754
              |.||.|    :.::.:.|..|:::      .|...|..|....|..||....:|.:..
  Rat  1745 WNVAQEKAYLQSLVDLMQQEGGPSQIGNALAFAVRYVTSQIHGARPGASKAVVMIIMDTSLDSVD 1809

  Fly   755 ----------AAEVPITAGDNPDNTSVGI-------SEVVPTIAEKAVEEVPTSEIPEQS 797
                      .|..||..||..|...:.|       |.||..   :.||::.|...|..|
  Rat  1810 TAVDAARSNRVAVFPIGVGDRYDEAQLRILAGPGASSNVVKL---QQVEDLLTMVTPGNS 1866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpn	NP_731674.1	rne	<9..167	CDD:236766
		rne	<109..300	CDD:236766	31/129 (24%)
		rne	<228..409	CDD:236766	48/246 (20%)
		rne	<331..594	CDD:236766	68/333 (20%)
		rne	<501..763	CDD:236766	72/351 (21%)
Vwf	NP_446341.1	VWD	35..179	CDD:278521
		C8	218..292	CDD:214843
		TIL	295..348	CDD:280072
		VWD	377..540	CDD:214566
		C8	580..648	CDD:285899
		TIL	652..707	CDD:280072
		VWD	856..1011	CDD:214566
		C8	1053..1127	CDD:214843
		TIL	1146..1196	CDD:280072	12/49 (24%)
		VWA_N2	1198..1276	CDD:292782	20/87 (23%)
		VWA	1277..1449	CDD:214621	36/182 (20%)
		VWA	1498..1658	CDD:278519	33/161 (20%)
		VWA	1691..1862	CDD:278519	39/173 (23%)
		VWD	1950..2102	CDD:278521
		C8	2136..2199	CDD:285899
		TIL	2203..2254	CDD:280072
		VWC	2257..2321	CDD:214564
		VWC	2431..2494	CDD:214564
		VWC	2581..2643	CDD:302663
		CT	2726..2807	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900