DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and MYOT

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_006781.1	Gene:	MYOT / 9499	HGNCID:	12399	Length:	498	Species:	Homo sapiens

Alignment Length:	388	Identity:	74/388 - (19%)
Similarity:	118/388 - (30%)	Gaps:	110/388 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SNGTNGRAFQRT-----QSRREALIPATTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAINN 93
            |...|.:...||     |..:||||       |.|::....:.|:.
Human   134 SQTANAKPIPRTPDHEIQGSKEALI-------QDLERKLKCKDTLL------------------- 172

  Fly    94 ISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPA 158
              :||:|||.....      |:.|.:..|::..:.|....|.|..:....:......:|
Human   173 --HNGNQRLTYEEK------MARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVP------ 223

  Fly   159 TTTTIDPATTTPTTTTRRTTRRPV-----ATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVK 218
                      |....:|.|:|..|     ......||..|...:.:....|....:...|..|..
Human   224 ----------TSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPA 278

  Fly   219 KPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEP-KAS 282
            ..:||.         ::..|..:|...:.:.|..... ||..:.|:..|.|.|.|...... :|:
Human   279 PDVSWY---------LNGRTVQSDDLHKMIVSEKGLH-SLIFEVVRASDAGAYACVAKNRAGEAT 333

  Fly   283 AIVHLRIVEPKTE-----LIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRR- 341
            ..|.|.::..:.:     :....::.|..|..|||.|.||....|.||  |..|.:.:..:..|
Human   334 FTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLF--WKRNNEMVQFNTDRI 396

  Fly   342 ----------------------GWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPA 382
                                  ||.| :..::        ....||..|....|.....|.||
Human   397 SLYQDNTGRVTLLIKDVNKKDAGWYT-VSAVN--------EAGVTTCNTRLDVTARPNQTLPA 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	18/92 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	18/86 (21%)
MYOT	NP_006781.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..151		4/16 (25%)
		Necessary for interaction with ACTN1	79..150		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..241		8/54 (15%)
		Necessary for interaction with ACTA1. /evidence=ECO:0000269\|PubMed:12499399	215..498		51/273 (19%)
		Necessary for interaction with FLNC	215..493		51/273 (19%)
		Ig	249..333	CDD:299845	18/93 (19%)
		I-set	250..340	CDD:254352	20/99 (20%)
		I-set	349..440	CDD:254352	20/101 (20%)
		Ig_Myotilin_C	366..440	CDD:143300	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910