DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Cadm3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_006497123.3	Gene:	Cadm3 / 94332	MGIID:	2137858	Length:	547	Species:	Mus musculus

Alignment Length:	556	Identity:	113/556 - (20%)
Similarity:	179/556 - (32%)	Gaps:	171/556 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 ASIAPN---GTAFGDAPSIPI------GVAPATTT----------TIDPATTTPTTTTRRTT--R 179
            ||..|.   |:|.|...::|:      ..||....          .::..|..|......:|  .
Mouse   106 ASAQPGRWPGSAMGAPSALPLLLLLACSWAPGGANLSQDGYWQEQDLELGTPAPLEEALSSTVWS 170

  Fly   180 RPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTF----- 239
            .|....:....|...| :|::  ||....|.|.||......:.|..       ...||.:
Mouse   171 NPDLLASQDSQPWTSD-ETVV--AGGTVVLKCQVKDHEDSSLQWSN-------PAQQTLYFGEKR 225

  Fly   240 -IADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEP--KASAIVHLRIVEPKTELIG--E 299
             :.|.|.|.| |..|...|:.|..|.|.|||.|.|.:.|.|  .|.::|.:..:..|..:.|  .
Mouse   226 ALRDNRIQLV-SSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKS 289

  Fly   300 STRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTT 364
            |.|..:..:   |.| .|...:|...:.|....::::     |.:|.|:      |.|...|.|.
Mouse   290 SLREKETAT---LNC-QSSGSKPAAQLTWRKGDQELH-----GDQTRIQ------EDPNGKTFTV 339

  Fly   365 TTTTTASTTTTTTSTTPATPSTTATGSTEGA-----TSSETLNGLVTITRSYILDAISQNDVSEL 424
            :::.                |...|...:||     .:.|:|.|
Mouse   340 SSSV----------------SFQVTREDDGANIVCSVNHESLKG--------------------- 367

  Fly   425 GAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAA 489
                     .:.||:|.: ||        ..|...::....|....|....:.....|:   ...
Mouse   368 ---------ADRSTSQRI-EV--------LYTPTAMIRPEPAHPREGQKLLLHCEGRGN---PVP 411

  Fly   490 TTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNSAPRTIV 554
            ....|:..                 .|...:|....::||.|.:.|.|||.|.|:.:::.
Mouse   412 QQYVWVKE-----------------GSEPPLKMTQESALIFPFLNKSDSGTYGCTATSNM----- 454

  Fly   555 LHVLNGEYSA---------SAIKSGSVSWSALIGCHGYLHWRNVSTLLTLLWIIKFALARDICQP 610
                 |.|:|         |.:.|.|.::.|:||  |.     |:.::.||.|:...|...:.:
Mouse   455 -----GSYTAYFTLNVNDPSPVPSSSSTYHAIIG--GI-----VAFIVFLLLILLIFLGHYLIR- 506

  Fly   611 NATSKATTRTSLLRAGDGA----TADVTRETGPKSG 642
               .|.|..|...:..|.|    ||.:..|.|...|
Mouse   507 ---HKGTYLTHEAKGSDDAPDADTAIINAEGGQSGG 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	29/99 (29%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	27/93 (29%)
Cadm3	XP_006497123.3	Ig1_Necl-1	181..275	CDD:143290	31/104 (30%)
		Ig2_Necl-1	296..378	CDD:143329	22/143 (15%)
		IG	388..465	CDD:214652	18/106 (17%)
		4.1m	503..518	CDD:128590	3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12439
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5205
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050