DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and PAPLN

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	179	Identity:	38/179 - (21%)
Similarity:	60/179 - (33%)	Gaps:	47/179 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 FGDAPSI-PIGVAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAY 208
            ||.|.:. |:|..|:       :...|....|....:|               :.:.:..|....
Human  1020 FGQAGAAGPLGAIPS-------SHPQPANRLRLDQNQP---------------RVVDASPGQRIR 1062

  Fly   209 LPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSP----NPERWSLQIKYVQLKDEG 269
            :.|..:......|.|  .|||                |.|.||    .|: .||.|..|.::|.|
Human  1063 MTCRAEGFPPPAIEW--QRDG----------------QPVSSPRHQLQPD-GSLVISRVAVEDGG 1108

  Fly   270 TYEC-QVSTEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIIS 317
            .|.| ..:.:.:....|.||::...|......|..|..|...:|.|:::
Human  1109 FYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDTARLLCVVA 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	22/96 (23%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	23/90 (26%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767
		Ig	914..>978	CDD:325142
		I-set	1049..1119	CDD:254352	21/103 (20%)
		IG	1139..1219	CDD:214652	5/19 (26%)
		PLAC	1235..1267	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900