DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	497	Identity:	90/497 - (18%)
Similarity:	164/497 - (32%)	Gaps:	154/497 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 NGRAFQRT---QSRREALI------PATTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAIN- 92
            ||..:.:|   ..:||:::      |...:..|::         :..|.:.|.|.....:|.|:
Human   197 NGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI---------VCRATNKAIPGGKETSVTIDI 252

  Fly    93 ------NISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSI 151
                  |:|      :.....||.|::..:.:.:...:  :||........|...  |.|:
Human   253 QHPPLVNLS------VEPQPVLEDNVVTFHCSAKANPA--VTQYRWAKRGQIIKE--ASGE---- 303

  Fly   152 PIGVAPATTTTID------PATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLP 210
                  ...||:|      |.:...|.....|...........|..|.:. |:::...|:.|...
Human   304 ------VYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEP-QSLLVDLGSDAIFS 361

  Fly   211 CNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQV 275
            |.........|.|::...|.:|:.::|                    |.:|.|:.:|.|.|.|:
Human   362 CAWTGNPSLTIVWMKRGSGVVLSNEKT--------------------LTLKSVRQEDAGKYVCR- 405

  Fly   276 STEPKASA---IVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYL 337
            :..|:..|   .|.|.:..|.. :....|:|...|.:.:::|.| ::..||..|.|
Human   406 AVVPRVGAGEREVTLTVNGPPI-ISSTQTQHALHGEKGQIKCFI-RSTPPPDRIAW--------- 459

  Fly   338 HNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLN 402
                .|:..:                ..:.|:...|..|.||            .||..|:.|::
Human   460 ----SWKENV----------------LESGTSGRYTVETIST------------EEGVISTLTIS 492

  Fly   403 GLVTITRSYILDAISQNDV-------------SELGAAAGVAVATETSTAQLLTEVEATSSTSGT 454
            .:|......|.:..:.|..             ||:.:.||:    |..:..:...:       |.
Human   493 NIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGL----EAESVPMAVII-------GV 546

  Fly   455 STGAG----LLASTSAAY-------AAGAAAGITTAATGDSA 485
            :.|||    :|.:|..|:       :.|..:||:...|...|
Human   547 AVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKA 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/94 (21%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	19/88 (22%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845
		IG_like	60..149	CDD:214653
		I-set	156..249	CDD:254352	10/60 (17%)
		Ig2_KIRREL3-like	171..252	CDD:143236	12/63 (19%)
		Ig_2	260..337	CDD:290606	15/96 (16%)
		I-set	341..422	CDD:254352	22/102 (22%)
		IGc2	355..406	CDD:197706	15/71 (21%)
		Ig5_KIRREL3	424..521	CDD:143306	23/139 (17%)
		IG_like	432..521	CDD:214653	22/130 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810