DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	465	Identity:	88/465 - (18%)
Similarity:	137/465 - (29%)	Gaps:	143/465 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PPTIDDYQTIISQAGTHAYLPC------NVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSV 248
            |..:...:.::...|..|.|||      .:.|..|..::....||
Human    24 PHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRD-------------------- 68

  Fly   249 FSPNPERW-----------SLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIVEP--KTELIGES 300
             .|...|:           .|.|:.|:|:||.:||||.:.....|....|.::.|  ..:::|..
Human    69 -LPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGP 132

  Fly   301 TRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTT-- 363
            :..:.||....|.|.......|...:.||  :..:.|......:|.::. ..|..|.:|.|.|
Human   133 SVSLVAGVPANLTCRSRGDARPTPELLWF--RDGVLLDGATFHQTLLKE-GTPGSVESTLTLTPF 194

  Fly   364 -------------TTTTTTASTTTTTTS-------TTPATPSTTATGSTE----GATSSETLNGL 404
                         :....|...|..|.|       |..|:|.|...|...    .||:...:.|.
Human   195 SHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 259

  Fly   405 --------VTITRSYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEA------TSSTSGTS 455
                    |...|...|:.::  |.|.|.......|:....:|...|.::.      .:.....|
Human   260 RWAKGGSPVLGARGPRLEVVA--DASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVS 322

  Fly   456 TGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFI 520
            ...|..||.|.|:.......:|                |.....|:...:.||
Human   323 VDVGEDASFSCAWRGNPLPRVT----------------WTRRGGAQVLGSGAT------------ 359

  Fly   521 KQITTASLIIPAVVKLDSGNYTCSPS-----------------NSAPRTIVLHVLNGEYSASAIK 568
                   |.:|:|...|:|:|.|...                 |:.|....||      ||.|..
Human   360 -------LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALH------SAPAFL 411

  Fly   569 SGSVSWSALI 578
            .|......|:
Human   412 RGPARLQCLV 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/108 (21%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	23/102 (23%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	23/109 (21%)
		IGc2	38..106	CDD:197706	21/88 (24%)
		I-set	126..224	CDD:254352	19/100 (19%)
		Ig2_KIRREL3-like	141..223	CDD:143236	15/84 (18%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	16/76 (21%)
		IG_like	234..308	CDD:214653	15/75 (20%)
		Ig	312..395	CDD:299845	18/117 (15%)
		I-set	317..395	CDD:254352	18/112 (16%)
		Ig	397..501	CDD:299845	8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810