DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	705	Identity:	126/705 - (17%)
Similarity:	219/705 - (31%)	Gaps:	276/705 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 NGRAFQRT---QSRREALI------PATTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAIN- 92
            ||..:.:|   ..:||:::      |...:..|::         :..|.:.|.|.....:|.|:
Mouse   191 NGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI---------VCRATNKAIPGGKETSVTIDI 246

  Fly    93 ------NISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSI 151
                  |:|      :.....||.|::..:.:.:...:  :||........|...  |.|:
Mouse   247 QHPPLVNLS------VEPQPVLEDNIVTFHCSAKANPA--VTQYRWAKRGHIIKE--ASGE---- 297

  Fly   152 PIGVAPATTTTID------PATTTPTTTTRRTTRRPVATTTLKPPPTIDDY---------QTIIS 201
                  ...||:|      |.:...|..        :.:|.|.  .|:|.|         |:::.
Mouse   298 ------LYRTTVDYTYFSEPVSCEVTNA--------LGSTNLS--RTVDVYFGPRMTSEPQSLLV 346

  Fly   202 QAGTHAYLPCNVKQLVKKP---ISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYV 263
            ..|:.|...|   ..:..|   |.|::...|.:|:.::|                    |.:|.|
Mouse   347 DLGSDAVFSC---AWIGNPSLTIVWMKRGSGVVLSNEKT--------------------LTLKSV 388

  Fly   264 QLKDEGTYECQVSTEPKASA---IVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLF 325
            :.:|.|.|.|: :..|:..|   .|.|.:..|.. :....|:|...|.:.:::|.| ::..||..
Mouse   389 RQEDAGKYVCR-AVVPRVGAGEREVTLTVNGPPI-ISSTQTQHALHGEKGQIKCFI-RSTPPPDR 450

  Fly   326 INWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATG 390
            |.|             .|:..:      .|..|:...|..|..|
Mouse   451 IAW-------------SWKENV------LESGTSGRYTVETVNT--------------------- 475

  Fly   391 STEGATSSETLNGLVTITRSYILDAISQNDV-------------SELGAAAGVAVATETSTAQLL 442
             .||..|:.|::.:|......|.:..:.|..             ||:.:.||:    |..:..:.
Mouse   476 -EEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGL----EAESVPMA 535

  Fly   443 TEVEATSSTSGTSTGAG----LLASTSAAY-------AAGAAAGITTAATGDSAATAATTSAWLT 496
            ..:       |.:.|||    :|.:|..|:       :.|...||:...|...|.......|.|.
Mouse   536 VII-------GVAVGAGVAFLVLMATIVAFCCARSQRSTGGRPGISGRGTEKKARLRLPRRANLK 593

  Fly   497 TMDAEAATTAATTTTTMLPSS-------SFIKQITTASLIIPAVVKLDSGNYTCSPSNSAPRTIV 554
            .: ..|............|||       :.|||:           .:|.|.:   ..:|..:.
Mouse   594 GV-VSAKNDIRVEIVHKEPSSGREAEDHTTIKQL-----------MMDRGEF---QQDSVLKQ-- 641

  Fly   555 LHVL--------------NGEYSASAIK----SGSVSWSALIGCHGYLHWRNVSTLLTLLWIIKF 601
            |.||              ||.||.:..|    :.::|.|:
Mouse   642 LEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSS------------------------- 681

  Fly   602 ALARDICQPNATSKATTRTSLLRAGDGATADVTRETGPK---SGASFHRVSSSIS 653
                  |||:                      .|.||.:   :|.||..:.|::|
Mouse   682 ------CQPD----------------------LRPTGKQRVPTGMSFTNIYSTLS 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	21/97 (22%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	20/91 (22%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416	12/63 (19%)
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416
		Ig strand E	210..214	CDD:409416	0/3 (0%)
		Ig strand F	224..229	CDD:409416	0/13 (0%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	15/90 (17%)
		Ig strand B	267..274	CDD:409353	0/6 (0%)
		Ig strand C	279..286	CDD:409353	2/6 (33%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	5/14 (36%)
		Ig	335..416	CDD:416386	21/104 (20%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	2/12 (17%)
		Ig strand C	365..371	CDD:409353	2/5 (40%)
		Ig strand E	381..387	CDD:409353	2/25 (8%)
		IgI_5_KIRREL3	418..515	CDD:409479	23/139 (17%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	2/16 (13%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	1/4 (25%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810