DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Nectin3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_067470.1	Gene:	Nectin3 / 58998	MGIID:	1930171	Length:	549	Species:	Mus musculus

Alignment Length:	361	Identity:	73/361 - (20%)
Similarity:	119/361 - (32%)	Gaps:	109/361 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 NVQEQHSYRITQDN-ATSAASIAPNGTAFGD-------APSIPIGVAPATTTT------------ 162
            :||..:..|:...| :.:.|:|..:...|.|       |.:.|:|.|.::||.
Mouse   112 SVQGDYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIK 176

  Fly   163 -----IDPATTTPTTTTRRTTRRPVA-------------TTTLKPPPT---IDDYQTIISQAGTH 206
                 ||....|........|.:|||             :||..|..|   :..|:...::....
Mouse   177 GPDSLIDGGNETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPTRFARG 241

  Fly   207 AYLPCNVKQ-LVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPE--------RWSLQIKY 262
            ..:.|.||. .::|.|.:              :||.|.::.      ||        .|.:..|.
Mouse   242 RRITCVVKHPALEKDIRY--------------SFILDIQYA------PEVSVTGYDGNWFVGRKG 286

  Fly   263 VQLKDEGTYECQVSTEPKASAIVHLRI--VEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLF 325
            |.||      |.....|.....|..|:  ..|...|..::|.|                ...||.
Mouse   287 VNLK------CNADANPPPFKSVWSRLDGQWPDGLLASDNTLH----------------FVHPLT 329

  Fly   326 INWFYNQKQIY---LHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTT-----TTTTSTTPA 382
            :|:    ..:|   :.|..|.|:: :::...::.|||:|...|....:|..     .|.....|.
Mouse   330 VNY----SGVYVCKVSNSLGQRSD-QKVIYISDPPTTTTLQPTVQWHSSPADVQDIATEHKKLPF 389

  Fly   383 TPSTTAT--GSTEGATSSETLNGLVTITRSYILDAI 416
            ..||.||  ..|.|...:..:.|.:.:....||..:
Mouse   390 PLSTLATLKDDTIGTIIASVVGGALFLVLVSILAGV 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	18/100 (18%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	19/96 (20%)
Nectin3	NP_067470.1	IG_like	64..166	CDD:214653	14/53 (26%)
		Ig1_Nectin-3_like	72..167	CDD:143295	14/54 (26%)
		Ig	170..265	CDD:299845	19/108 (18%)
		IG_like	287..348	CDD:214653	17/86 (20%)
		Ig_3	<287..342	CDD:290638	15/80 (19%)
		TM_EGFR-like	402..432	CDD:213052	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910