DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and ADAMTSL3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_011520124.1	Gene:	ADAMTSL3 / 57188	HGNCID:	14633	Length:	1718	Species:	Homo sapiens

Alignment Length:	393	Identity:	75/393 - (19%)
Similarity:	131/393 - (33%)	Gaps:	128/393 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IRGQAEETSILNSNGTNGRAFQRTQSRR-----------EALIPATT--QMAQTL---------D 64
            |.|.|:||.:|...||:.|...|...|.           ||.....|  :|.|..         |
Human  1010 IAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDD 1074

  Fly    65 KASAFRPTMAAALDAAAPNRSSNN--------------------------VAINNIS---NNGDQ 100
            ...:.:|.:.|.|...:.:..|.|                          ..|.|:|   ..|:.
Human  1075 DHISNQPFLRALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEV 1139

  Fly   101 RLRLTAALEANLIMSNRNVQEQH-SYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTID 164
            ...|.:.|...|:......|..| .:|..|:....||.:.      |:..|:
Human  1140 SDDLASQLIYQLVAELAKAQPTHMQWRGIQEETPPAAQLR------GETGSV------------- 1185

  Fly   165 PATTTPTTTTRRTTRRPVATTTLK--PPPTIDDYQTIISQAGTHAYLP---------CNVKQLVK 218
             :.::....:.:.|.:|.....::  .||:|...:||.|:.|...|:.         |::....:
Human  1186 -SQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSE 1249

  Fly   219 KPISWLRMRDGHIL------TVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVS- 276
            ...:|  .:||.:|      .:|.|..|..|        ||.|          |::|.|||.|:
Human  1250 ATYTW--TKDGTLLQPSVKIILDGTGKIQIQ--------NPTR----------KEQGIYECSVAN 1294

  Fly   277 ---TEPKASAIVHLR---IVEPKTELIGESTRHVKA----------GSQVKLRCIISQALEPPLF 325
               ::.::|::::..   |:..:..:......|:..          |:.|.:||.:....:|.
Human  1295 HLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPN-- 1357

  Fly   326 INW 328
            |.|
Human  1358 ITW 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	24/113 (21%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/107 (20%)
ADAMTSL3	XP_011520124.1	TSP1	78..124	CDD:214559
		TSP1	453..>473	CDD:214559
		TSP1	513..>542	CDD:214559
		TSP1	598..>618	CDD:214559
		TSP1	734..787	CDD:214559
		TSP1	790..847	CDD:214559
		TSP1	853..908	CDD:214559
		Ig	956..1020	CDD:299845	5/9 (56%)
		Ig	1238..1302	CDD:143165	18/83 (22%)
		IG_like	1336..1410	CDD:214653	7/27 (26%)
		IGc2	1341..1401	CDD:197706	7/22 (32%)
		TSP_1	1516..1571	CDD:301595
		PLAC	1686..1716	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910