DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and ush2a

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	692	Identity:	133/692 - (19%)
Similarity:	209/692 - (30%)	Gaps:	267/692 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LIPATTQMAQ---------TLDKASAFRPTMAAALDAAAPN----------------RSSNNVAI 91
            |:|.:|.:.|         ||...|..|...::..:..|||                |..|.|
Zfish  2225 LVPGSTYLFQIAACTGGGCTLSDPSTARTEESSPEEVPAPNILSLSPHSLHLSWTPPRKPNGV-- 2287

  Fly    92 NNISNNG---DQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAA----------SIAPNG- 142
              ||:.|   |..|...::|.|:.: .:.:....||:|:....|...|          .:.|.|
Zfish  2288 --ISSYGLWMDGTLVQNSSLMASEV-GDLSPWSLHSFRVQACTAQGCALGPLVESRTLEMPPVGH 2349

  Fly   143 -------------TAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATT--------- 185
                         .|..:||:.|.|....|.....|.....:..|..|..|.:.:|
Zfish  2350 VTLVVFSETPHSVRAKWEAPAEPNGNLTYTVLFAGPGQNFSSLDTPDTEMRELLSTGKEGQWVSI 2414

  Fly   186 -TLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVK-KPISWL---RMRDGHIL--------TVDQT 237
             .|.|   ..:|..::.        .||....|: .|:|..   ...||.:.        |..|.
Zfish  2415 GGLLP---YSNYSVMVK--------ACNSLGCVESSPVSVSLPPGAPDGLLAPRLAAATPTSLQV 2468

  Fly   238 TFIADQRFQSVFSPNPERWSLQIK-------YVQLKDEGTYECQVSTEPKASAIVHLRIV----- 290
            ::.|..|..   :|...|:.||::       :..:.||.|......|:.:.....|.|::
Zfish  2469 SWAAPARHN---APGALRYRLQMRSSASTQLHQLMDDETTTFSHTVTDLEPFTEYHFRLLVSNSY 2530

  Fly   291 -EPKTELIGESTRHVKAGSQVKLRCIISQALEPPL---------FINW-----------FYNQKQ 334
             |..:..:...|...:.|           |::||:         ||:|           .||
Zfish  2531 GETSSPWVSLFTAQDRPG-----------AVDPPVLSDIQSRSAFISWSPPSQPNGIITHYN--- 2581

  Fly   335 IYLHNRRGWRTEIERIDLPAEVPTTSTT------------------TTTTTTTASTTTTTTSTTP 381
            || .||:          |...||..||:                  .|....|.|..:.|.:|.|
Zfish  2582 IY-QNRQ----------LTTSVPENSTSHMLSHLTPFQQYTIQVEACTAAGCTLSAESHTINTPP 2635

  Fly   382 ATP---------STTAT-------------GSTEGATSSETLNGLVTITRSYILDAISQNDVSEL 424
            |.|         |.|.|             |..:|.|....::|...|:
Zfish  2636 APPEDVPAPQLYSDTPTSVLLSWAAPRLVNGELDGYTVERRVSGTQEIS---------------- 2684

  Fly   425 GAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAA 489
                  .||| ....|.||.::::::.|..|       |......|....|            .:
Zfish  2685 ------TVAT-IQPNQTLTYLDSSATLSPWS-------SYEYRIVAHTRLG------------GS 2723

  Fly   490 TTSAWLTTMDAEAATTAATTTTTMLPSSSFI-----KQITTASLIIPAVVKLDSG---NYTC-SP 545
            .:|.|      |..||..:....|.|....:     .|:|.|:.:||      :|   .|.. .|
Zfish  2724 NSSVW------EKVTTRPSRPAGMQPPDGVVLGPESVQVTWAAPLIP------NGEIERYEIRMP 2776

  Fly   546 SNSAPRT---IVLHVLNG--EYSASAIKSGSVSWSALIGCHG 582
            ....|.|   ::.|.::|  .|:..:|        .::.|.|
Zfish  2777 EPRIPHTNMSLLTHTVSGLMPYTGYSI--------TILACSG 2810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/110 (18%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/104 (20%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020	7/27 (26%)
		FN3	2258..2341	CDD:238020	18/87 (21%)
		FN3	2352..2443	CDD:238020	18/101 (18%)
		FN3	2447..2544	CDD:238020	18/99 (18%)
		FN3	2547..2633	CDD:238020	22/110 (20%)
		FN3	2635..2733	CDD:238020	25/145 (17%)
		FN3	2743..2807	CDD:238020	15/77 (19%)
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900