DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and hspg2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_021325650.1	Gene:	hspg2 / 565429	ZFINID:	ZDB-GENE-080807-4	Length:	3701	Species:	Danio rerio

Alignment Length:	755	Identity:	145/755 - (19%)
Similarity:	237/755 - (31%)	Gaps:	238/755 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RGQAEETSILNSNGTNGRAF------QRTQSRREALIPATTQMAQTLD------KASAFRPTMAA 75
            |.|.||.........:...:      ||:.:|.:|.|...|..::.::      ||.:.|.....
Zfish  1865 RRQGEELHFPGIQSNDAGVYICTCRDQRSSNRSKAEIVVATLPSKPIEVFIEEPKAQSVRVGSTV 1929

  Fly    76 ALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQEQHS--YRITQDNATSAASI 138
            :....|.::......:.....||....|   |::.|.|::.:|||.:.:  |..|..|....
Zfish  1930 SFICTAKSKLPAYTLVWTRKGNGKLPNR---AMDFNGILTIQNVQPEDAGIYVCTGSNMLGM--- 1988

  Fly   139 APNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTR--RPVATTTLKPPPTIDDYQTIIS 201
                    |..|..:.|..|:.:.:...........|:...  :|||  ||.||     .||:
Zfish  1989 --------DEGSAVLYVPEASQSQMFYTAYEMFEGHRKPAEGVQPVA--TLSPP-----VQTV-- 2036

  Fly   202 QAGTHAYLPCNVKQLVKKPISWL-----RMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIK 261
            :.|..|...|.|.......:.|:     |:....::...|.|                     |.
Zfish  2037 KEGDVAQFRCTVTGNPTPAVEWIGGSGKRISSKAVIRNGQLT---------------------IS 2080

  Fly   262 YVQLKDEGTYECQVST---EPKASAIVHLRIVEPKTEL----IGESTRHVKAGSQVKLRCIISQA 319
            .|...|||.|.|:...   |..|..::|::.......|    :......:..|..::|.|   :|
Zfish  2081 SVDRSDEGEYICKALNTHGEHTARGVLHVQSTGQPNGLPHVQVSPQRVEIYEGETLRLYC---RA 2142

  Fly   320 L-EPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPA-------------------EVPTTSTTTT 364
            : .|...:.|          |:||.....:.|  |:                   |:......|.
Zfish  2143 IGSPTPSLKW----------NKRGGSLPPQAI--PSHGFHQFKSNSLDVLQRRIEELQARMDRTD 2195

  Fly   365 TTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQNDVSELGAAAG 429
            ..|........:.:.|.....|.|.||:|....       |::|:       .:|.:|      |
Zfish  2196 IGTLVVPNIRLSDAGTYLCVGTNAAGSSEAHID-------VSVTK-------GENILS------G 2240

  Fly   430 VAVATETSTAQLLTEVEATSSTSGTSTGA-------GLLASTS----------AAYAAGAAAGIT 477
            |.:...:::......::......|||||:       |||:|..          .|.|......|.
Zfish  2241 VIIQPPSASVIEGEALDLNCLVPGTSTGSVKWSRAGGLLSSNHQVLETRLRILRASADDTGDYIC 2305

  Fly   478 TAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTAS--------------- 527
            |...|.| ...||.|..:|   :.|:....|...::.|.|:.:||..:||
Zfish  2306 TVENGPS-PQKATVSVSVT---SSASLGLQTPIISIEPHSAVVKQGESASFRCKVHNGAQPVRLE 2366

  Fly   528 ------LIIPAVVKL---------------DSGNYTCSPSN--------------SAPRTIVLHV 557
                  |.:|..||:               :.|.|.|..||              .:|:.:|...
Zfish  2367 WKLTNNLPLPDNVKVGPDSSIMTVTNAQAKNQGTYRCVASNLYGMTHSIVSLIVRESPKAVVTPA 2431

  Fly   558 ----------LNGEYSASAIKSGSVSWSALIGCHGYLHWRNVSTLLTLL------WIIKFALARD 606
                      :|.|..|:.....||.|..|.        .|..|:|:..      .||:..:||.
Zfish  2432 GPVRVRVGDPINLECQAAGEPRPSVRWHRLD--------NNRKTMLSSTVPVDSSAIIQVLVARP 2488

  Fly   607 ------ICQPNATSKATTRTSLLRAGDGATADVTRETGPK 640
                  :|... .::.||.|.:         :|..|.||:
Zfish  2489 EDSGTYVCSAQ-NNQGTTETRV---------EVFVEGGPQ 2518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/99 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	18/93 (19%)
hspg2	XP_021325650.1	SEA	84..198	CDD:321958
		LDLa	216..251	CDD:238060
		LDLa	277..311	CDD:238060
		LDLa	317..351	CDD:238060
		LDLa	360..395	CDD:238060
		Ig_Perlecan_like	413..490	CDD:143220
		Laminin_B	598..732	CDD:306547
		EGF_Lam	766..814	CDD:238012
		EGF_Lam	831..869	CDD:238012
		Laminin_EGF	871..923	CDD:278482
		Laminin_B	991..1125	CDD:306547
		Laminin_EGF	1159..1206	CDD:278482
		EGF_Lam	1208..1261	CDD:238012
		Laminin_EGF	1272..1315	CDD:278482
		Laminin_B	1536..1671	CDD:306547
		EGF_Lam	1705..1754	CDD:238012
		EGF_Lam	1755..1811	CDD:238012
		IG_like	1823..1903	CDD:214653	9/37 (24%)
		Ig_Perlecan_like	1911..1996	CDD:143231	18/98 (18%)
		I-set	2025..2109	CDD:254352	26/113 (23%)
		I-set	2119..2231	CDD:254352	21/133 (16%)
		I-set	2241..2309	CDD:333254	14/67 (21%)
		Ig_3	2333..2407	CDD:316449	13/73 (18%)
		Ig_3	2427..2500	CDD:316449	16/81 (20%)
		I-set	2517..2606	CDD:254352	1/2 (50%)
		I-set	2610..2693	CDD:333254
		I-set	2699..2778	CDD:333254
		I-set	2785..2867	CDD:254352
		I-set	2871..2954	CDD:254352
		LamG	2961..3119	CDD:238058
		EGF_CA	<3146..3175	CDD:238011
		LamG	3226..3377	CDD:238058
		EGF	3402..3433	CDD:306513
		EGF_CA	3441..3470	CDD:238011
		LamG	3497..3671	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910