DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and lrig1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	287	Identity:	58/287 - (20%)
Similarity:	82/287 - (28%)	Gaps:	104/287 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TSAASIAPNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDD-- 195
            ||.....|......|.|...|.|.|.||..:.......|.|...::..|:..|.||...|:..
Zfish   468 TSIYQAPPQSFVCDDLPKPQITVHPVTTAAVLGKDVRLTCTAASSSSSPMTFTWLKDQETLRQAE 532

  Fly   196 ---------------------------------YQTIIS-------------------------- 201
                                             ||.|||
Zfish   533 VENFAHVRASDGGVMEYTTILHLRHVTFNHEGRYQCIISNHFGSSYSNKARVTVNVLPSFVKTPR 597

  Fly   202 ----QAGTHAYLPCNVKQLVKKPISWLRMRDG------------HILTVDQTTFIADQRFQSVFS 250
                :.||.|.|.|..:......::|  .:||            .::..|...||.|
Zfish   598 DITIRTGTKARLECAAEGHPTPQVAW--QKDGGTDFPAARERRMRVMPDDDVFFIMD-------- 652

  Fly   251 PNPERWSLQIKYVQLKDEGTYECQV-STEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRC 314
                        |:.:|.|.|.|.. :|....||.|.|.::|..........|:|..|..|.|:|
Zfish   653 ------------VKPEDMGVYSCTAKNTAGMISANVTLTVLETPHLAQEMEDRNVVVGETVALQC 705

  Fly   315 IISQAL-EPPLFINWFYNQKQIYLHNR 340
               :|| .||..|.|...::.:...:|
Zfish   706 ---KALGSPPPRITWLKGEEPLRASDR 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	26/134 (19%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	22/98 (22%)
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470
		leucine-rich repeat	63..84	CDD:275380
		LRR_RI	77..334	CDD:238064
		LRR_8	83..142	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		LRR_8	132..191	CDD:290566
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..180	CDD:275380
		leucine-rich repeat	181..203	CDD:275380
		LRR_8	202..262	CDD:290566
		leucine-rich repeat	204..227	CDD:275380
		leucine-rich repeat	228..251	CDD:275380
		LRR_8	251..310	CDD:290566
		leucine-rich repeat	252..275	CDD:275380
		leucine-rich repeat	276..299	CDD:275380
		LRR_8	299..358	CDD:290566
		leucine-rich repeat	300..323	CDD:275380
		leucine-rich repeat	324..347	CDD:275380
		leucine-rich repeat	348..372	CDD:275380
		LRR_4	373..414	CDD:289563
		LRR_8	374..433	CDD:290566
		leucine-rich repeat	375..398	CDD:275380
		leucine-rich repeat	399..420	CDD:275380
		LRRCT	433..481	CDD:214507	3/12 (25%)
		Ig_3	485..572	CDD:290638	16/86 (19%)
		IG_like	492..586	CDD:214653	15/93 (16%)
		I-set	590..680	CDD:254352	22/111 (20%)
		Ig_1	607..681	CDD:143240	20/95 (21%)
		I-set	684..771	CDD:254352	13/49 (27%)
		IGc2	698..761	CDD:197706	11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910