DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and hmcn1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_005160777.1	Gene:	hmcn1 / 559150	ZFINID:	ZDB-GENE-041014-322	Length:	5623	Species:	Danio rerio

Alignment Length:	601	Identity:	121/601 - (20%)
Similarity:	191/601 - (31%)	Gaps:	163/601 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NSNGTNGRAFQRTQSRREALIPATTQMAQTLDKASAFRPTM-AAALDAAAPNRSSNNVAINNISN 96
            |:.||..|..|.|....    |.......|||.......|: ..|..:..|..:.....||..:.
Zfish  3956 NAAGTAHRHVQLTVHES----PVIQSHPSTLDVILNNHVTLPCRATGSPRPTITWQKEGINIFTT 4016

  Fly    97 NGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTT 161
            .|.    .|......|.:|...|::..:|.....|        |.|||.|
Zfish  4017 GGG----FTVLPNGGLQISKAKVEDSGTYMCVAQN--------PAGTALG--------------- 4054

  Fly   162 TIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRM 226
                      .|..|....||.|:.::.      |...:..:.|   |.||.:......:||  .
Zfish  4055 ----------KTKLRVQVPPVITSDIRA------YTVALDVSVT---LQCNSEGFPTPSVSW--H 4098

  Fly   227 RDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKASAI-VHLRIV 290
            :||.:|        ::...|.|.|..    :|||.:.|..|.|.|.|.|:....:|:: :.|.:.
Zfish  4099 KDGQLL--------SESVRQRVLSTG----ALQIAFAQPGDTGRYTCTVANVAGSSSLDISLTVQ 4151

  Fly   291 EPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAE 355
            .|.:..:|||...|...:|..|.|:.....:|.  |.|                   |:.|
Zfish  4152 IPPSIRVGESEVSVVENTQALLTCVADGVPQPT--ITW-------------------EKDD---- 4191

  Fly   356 VPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSY--ILDAISQ 418
            :|.|.||...|..........|:....:.|.|..|:......|.|::..:....::  :|..::.
Zfish  4192 IPLTDTTAEYTILPTGDLLIDTAQPEDSGSYTCVGTNSMGQDSRTISLSIHTHPAFTELLGDVAL 4256

  Fly   419 NDVSELGAAAGVA---------------VATE----TSTAQLLTEVEATSSTSGTST-----GAG 459
            |....|....||.               |..:    ...::|:.| ..:...|||.|     ..|
Zfish  4257 NKRERLLMVCGVTGIPPPKITWTFNNNIVPAQYDHYNGHSELVIE-RVSKDDSGTYTCMAENSVG 4320

  Fly   460 LLASTSAAYA-----------------AGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAA 507
            .:.|....|.                 .|..|.:.....||...|...:...:.
Zfish  4321 SIKSLGFVYVKEPPIIDGDVHSNRIEPLGGNAILNCEVRGDPLPTIQWSKKGIN----------- 4374

  Fly   508 TTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNSA---PRTIVLHV-----LNGEYSA 564
                  :..|:.|:|:...||.|...|..|:|||.|..:|.|   .||:.|.:     :..|...
Zfish  4375 ------VQISNRIRQLDNGSLAIYGTVSEDAGNYMCVATNDAGVVERTVTLTLQRSPTITVEPVE 4433

  Fly   565 SAIKSGSVSWSALIGC 580
            :.:.:||   :.::.|
Zfish  4434 TVVDAGS---TVVLNC 4446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/92 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	23/86 (27%)
hmcn1	XP_005160777.1	VWA_2	36..206	CDD:290253
		IG_like	443..510	CDD:214653
		I-set	514..600	CDD:254352
		ig	522..596	CDD:278476
		I-set	604..688	CDD:254352
		Ig	618..689	CDD:299845
		I-set	694..781	CDD:254352
		IGc2	708..771	CDD:197706
		I-set	785..876	CDD:254352
		Ig	789..876	CDD:299845
		IG	888..969	CDD:214652
		IGc2	895..959	CDD:197706
		I-set	973..1060	CDD:254352
		Ig	990..1059	CDD:299845
		IG	1084..1162	CDD:214652
		Ig	1092..1159	CDD:143165
		I-set	1166..1251	CDD:254352
		IGc2	1179..1241	CDD:197706
		I-set	1251..1348	CDD:254352
		Ig	1254..1348	CDD:299845
		I-set	1360..1441	CDD:254352
		IGc2	1367..1431	CDD:197706
		I-set	1450..1535	CDD:254352
		IGc2	1461..1525	CDD:197706
		IG_like	1547..1628	CDD:214653
		Ig	1558..1625	CDD:143165
		I-set	1641..1722	CDD:254352
		Ig	1641..1718	CDD:299845
		Ig	1725..1817	CDD:299845
		IG	1738..1815	CDD:214652
		Ig	1818..1908	CDD:299845
		IG	1826..1908	CDD:214652
		IG	1922..2001	CDD:214652
		Ig	1927..2001	CDD:299845
		IG	2014..2093	CDD:214652
		IGc2	2019..2083	CDD:197706
		Ig	2096..2186	CDD:299845
		IG_like	2107..2184	CDD:214653
		Ig	2187..2280	CDD:299845
		I-set	2197..2277	CDD:254352
		Ig	2292..2371	CDD:299845
		IG	2292..2369	CDD:214652
		I-set	2373..2463	CDD:254352
		IGc2	2391..2453	CDD:197706
		IG	2476..2556	CDD:214652
		IGc2	2484..2546	CDD:197706
		IG	2572..2652	CDD:214652
		IGc2	2583..2642	CDD:197706
		I-set	2670..2751	CDD:254352
		IGc2	2678..2741	CDD:197706
		IG	2774..2850	CDD:214652
		IGc2	2777..2840	CDD:197706
		I-set	2864..2945	CDD:254352
		Ig	2864..2938	CDD:299845
		Ig	2949..3039	CDD:299845
		IG_like	2957..3037	CDD:214653
		I-set	3051..3132	CDD:254352
		IGc2	3059..3122	CDD:197706
		I-set	3154..3226	CDD:254352
		Ig	3154..3223	CDD:143165
		Ig	3229..3323	CDD:299845
		I-set	3238..3321	CDD:254352
		IG	3335..3415	CDD:214652
		Ig	3343..3415	CDD:299845
Ig	3418..3508	CDD:299845
IG	3428..3508	CDD:214652
IG	3520..3601	CDD:214652
Ig	<3533..3603	CDD:299845
I-set	3614..3694	CDD:254352
IGc2	3620..3684	CDD:197706
Ig	3697..3787	CDD:299845
IG_like	3704..3785	CDD:214653
Ig	3788..3878	CDD:299845
I-set	3789..3878	CDD:254352
IG_like	3891..3969	CDD:214653	5/12 (42%)
Ig	3899..3968	CDD:299845	5/11 (45%)
IG_like	3979..4060	CDD:214653	21/117 (18%)
Ig	3990..4052	CDD:299845	14/73 (19%)
I-set	4064..4150	CDD:254352	27/108 (25%)
IGc2	4080..4140	CDD:197706	21/76 (28%)
Ig	4161..4241	CDD:299845	21/104 (20%)
IG_like	4161..4241	CDD:214653	21/104 (20%)
I-set	4245..4324	CDD:254352	13/79 (16%)
IGc2	4260..4320	CDD:197706	10/60 (17%)
Ig	4352..4420	CDD:299845	20/84 (24%)
I-set	4425..4511	CDD:254352	4/25 (16%)
Ig	4439..4512	CDD:299845	3/11 (27%)
TSP1	4518..4569	CDD:214559
TSP1	4583..4626	CDD:214559
TSP1	4631..4683	CDD:214559
TSP1	4688..4740	CDD:214559
TSP1	4745..4797	CDD:214559
TSP1	4802..4854	CDD:214559
nidG2	4855..5070	CDD:238158
EGF_CA	5091..5130	CDD:214542
EGF_CA	5131..5174	CDD:284955
EGF_CA	5176..5213	CDD:214542
EGF_CA	5214..5251	CDD:214542
EGF_CA	5256..5297	CDD:284955
EGF_CA	5299..5338	CDD:214542
EGF_CA	5420..5459	CDD:214542
EGF_CA	5460..5496	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910