DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and sdk1a

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	850	Identity:	161/850 - (18%)
Similarity:	252/850 - (29%)	Gaps:	281/850 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALLICLPAIRGQAEETSILNSNGTNGRAFQRTQSRREALI-PATTQM------AQTLD------K 65
            |.|.|:...|...:.:.:...||....:...:.|||..:| |.:|.:      |..||      :
Zfish   341 ATLECVANARPVEKLSLVWRRNGVEVASGVGSFSRRLTIINPTSTDVGMYVCEALLLDSSVKPAE 405

  Fly    66 ASAFRPTMAAALDAAAPNRSS----------------------------------NNVAINNISN 96
            |.||.....|....|.|.|..                                  ||.....||:
Zfish   406 ARAFLSITEAPYFTAEPRRKMMGEVEKSVDIQCQARGVPMPKLEWYKDAVPLSKLNNPRYKIISS 470

  Fly    97 NGDQRLRLTAALEANLIM----SNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSIPI---- 153
            .|.|..:|..: :|.:..    ::....:.|:|       ....|:||..|    ||.:.|
Zfish   471 MGLQVRKLQPS-DAGIFQCFARNSAGEAQVHTY-------LDVTSMAPAFT----APPLDITVTD 523

  Fly   154 GVAPATTTTIDPATTTPTTTTRRTTR----------------------RPV-------------- 182
            |...|.|..:..| ..|....||.|:                      :||
Zfish   524 GAVAAFTCRVSGA-PKPAIVWRRDTQILASGSVQIPRFTLLESGGLQIQPVVLQDTGNYTCYAAN 587

  Fly   183 --------------ATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILT 233
                          :.|::..|||  |.:.|   .||.|.|.|......:..:.::..:|..:::
Zfish   588 SEGAINASASLTVWSRTSISSPPT--DRRVI---KGTTAILECGATHDPRVGVRYVWKKDEELVS 647

  Fly   234 VDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEP-KASAIVHLRIVEPKTELI 297
            ..:...|:.|           ..||.|......|.|.|.|.|.:|. ..|....|.::|     :
Zfish   648 HSRGGRISLQ-----------EGSLHISQTWSGDIGNYTCDVISEAGNESKEARLEVIE-----L 696

  Fly   298 GESTRHVKAGSQVKLRCIISQALEPPLFINWF--YNQKQIYLH-------NRRGWRTEIERIDLP 353
            ..|.|::    |..|....|::::    ::|.  ::.....||       |...||..:..:|
Zfish   697 PHSPRNL----QASLNANDSRSVD----LSWMRPFDGNSPLLHYVVELSENNSPWRVYLSDVD-- 751

  Fly   354 AEVPTTSTTTTTTTTTA------------------STTTTTTSTTPATPST-----TATGSTEGA 395
               |:.:.......|.|                  ||.|.........||.     .|:|.|..:
Zfish   752 ---PSGTGAMVKGLTPARSYQFRVCAVNQVGRGQYSTETNRLMLREEPPSAPPKNIVASGRTNQS 813

  Fly   396 TSSE-------TLNGLVTITRSYILDAISQNDVSELGAAAGVAVATETSTAQ----LLTEVEATS 449
            ...:       .|||   :.|.|:|.       ..|....|.......|:.:    |:||:...:
Zfish   814 IMVQWQPPPEPQLNG---VLRGYVLR-------YRLAGLPGEYQQKNISSPEINYCLITELIIWT 868

  Fly   450 S-----TSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTS----------------- 492
            .     .:.|..|.|:.:.....|   ...|:.||......|.|..::
Zfish   869 QYEIQVAAYTGAGLGVFSQPVTEY---TLQGVPTAPPQGVEAKAVNSTTIEFSWNPPPQQFINGI 930

  Fly   493 -------AWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDS-GNYTCSPS--- 546
                   ||......|......|..........:|..:...|..:.:|:...: ||...||.
Zfish   931 NQGYKLMAWPERSPEEVIVVTITPDYHGTRHLGYISGLRKFSWYLTSVLCFTTPGNGPRSPPKLV 995

  Fly   547 ---NSAPRTIVLHVLNGEYSASAIKSGS--VSWSALIGCHGYLHWRNVSTLLTLLWII----KFA 602
               ...|..:      |..|.:.|...|  |||...:..:|.:....||      |.:    :..
Zfish   996 QTFEDIPGPV------GRLSFTEILDTSLKVSWEEPVDKNGIITGYLVS------WEVQGNNQSR 1048

  Fly   603 LARDICQPNATSKATTRTSL----------LRAGDGATADVTRET-------GPKSGASFHRVSS 650
            :||::.......|.|..|||          ..||.|.....|..:       ||.|.....::||
Zfish  1049 VARNLANTTLDYKVTGLTSLTTYTLEVAAMTEAGVGTVTSSTISSGVPPELPGPPSNLVISKISS 1113

  Fly   651 SISAT 655
            . |||
Zfish  1114 R-SAT 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/92 (22%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	19/86 (22%)
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352
		Ig	125..204	CDD:299845
		IG_like	222..302	CDD:214653
		Ig	236..287	CDD:299845
		Ig_3	322..394	CDD:290638	12/52 (23%)
		I-set	323..412	CDD:254352	18/70 (26%)
		I-set	416..505	CDD:254352	13/96 (14%)
		Ig	436..500	CDD:299845	8/64 (13%)
		I-set	510..600	CDD:254352	15/94 (16%)
		Ig	527..600	CDD:299845	9/73 (12%)
		I-set	605..693	CDD:254352	24/103 (23%)
		Ig	610..693	CDD:299845	23/98 (23%)
		FN3	697..788	CDD:238020	17/103 (17%)
		fn3	800..886	CDD:278470	18/95 (19%)
		FN3	901..997	CDD:238020	13/95 (14%)
		FN3	1002..1090	CDD:238020	22/99 (22%)
		FN3	1100..1196	CDD:238020	7/18 (39%)
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810