DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and igsf9a

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_005155702.1	Gene:	igsf9a / 557459	ZFINID:	ZDB-GENE-060503-288	Length:	1619	Species:	Danio rerio

Alignment Length:	653	Identity:	119/653 - (18%)
Similarity:	205/653 - (31%)	Gaps:	202/653 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELAKMPRRLILLALLICLPAIRGQAEETSILNSNGTNGRAFQRTQSRREALIPATTQMAQTLDK 65
            |.|..:|...:::|:| ||......|||             ..|.:....|::|
Zfish     1 MRLKNLPLLEVIVAVL-CLFNDTSAAEE-------------HVRAKKDSSAVLP----------- 40

  Fly    66 ASAFRPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRITQD 130
                     .:|.|...:.|::...|..:....|..:.:...:       :..|...:..|::..
Zfish    41 ---------CSLPAPQKDSSASQYVIEWVRQGFDTPIFMQLGV-------HPRVHPDYDGRVSLF 89

  Fly   131 NATSAASIAPNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDD 195
            ..|   |:..:|....|.......:.|...|| :.|.::.:.|....|..||.|.|  .||.::.
Zfish    90 GGT---SLQMSGLQLEDEGWYECRILPLDQTT-EEAGSSGSWTRLSVTAPPVLTET--SPPEVEV 148

  Fly   196 YQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQI 260
            :      .|....|.|..:...:..|:|  .:||..:.......:.:             .|:..
Zfish   149 F------VGRSLTLKCAAQGNPRPTITW--SKDGAPIKPQHKVKMVN-------------GSVSF 192

  Fly   261 KYVQLKDEGTYECQVS-TEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQA-LEPP 323
            ..|..:..|.|:|..| :|..|:.:..|:|:.|...:|..|...:......||:|   || .:||
Zfish   193 HAVSREAAGQYQCYTSNSEGNATHVTRLKIIGPPVIIIPPSDTVLNMSQDAKLKC---QAEADPP 254

  Fly   324 LFINWFYNQKQIYLHNRRGWRTEIERID-LPAEVPTTSTTTTTTTTTA-----STTTTTTSTTPA 382
                     ...|:..|:|  .:|..|| |.:.:......|...:..|     :.|...|:..|.
Zfish   255 ---------NMTYVWQRQG--VDIYHIDSLKSRIKVIVDGTLLISRLAPEDSGNYTCMPTNGLPV 308

  Fly   383 TPSTTATGSTE---GATSSETLNGLVTITRSYI------------LDAISQNDVSELGAAAGVAV 432
            :||.:|..:.:   .......|..|.|..|..|            :|.|......:||...|..:
Zfish   309 SPSASAVLTVQHPAQVIQMPKLTFLPTGMRGAIVCPVRAEPPLSHIDWIKDGKPLDLGMYPGWTL 373

  Fly   433 ATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTT 497
            |::.|                                      |..|...|.||     ..::.|
Zfish   374 ASDGS--------------------------------------IVIATVNDDAA-----GVYICT 395

  Fly   498 MDAEAATTAATTTTTML----------PSSSFIKQITT--------------------------- 525
            ......||..:..||::          |.:.:.:.:.|
Zfish   396 PYNSFGTTGQSEPTTVILQDPPSFKVSPRNEYRQDVGTMLVIPCQMVGNPAPKVNWRKIGAATRS 460

  Fly   526 -------ASLIIPAVVKLDSGNYTCSPSNSAP----RTIVLHVLNGEYSASAI------KSGSVS 573
                   .|||:..:.|...|.:.||.||...    :|:||.:....::.|::      ...:||
Zfish   461 LFTLAGNGSLILHPLSKDHQGEWECSSSNRVATVSIKTMVLVLGTSPHAVSSVSVIPGTNQANVS 525

  Fly   574 WSA 576
            |.|
Zfish   526 WVA 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	16/92 (17%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	16/86 (19%)
igsf9a	XP_005155702.1	IG_like	27..110	CDD:214653	15/125 (12%)
		Ig	35..111	CDD:299845	13/105 (12%)
		I-set	140..221	CDD:254352	18/103 (17%)
		IGc2	151..212	CDD:197706	13/75 (17%)
		Ig	233..318	CDD:299845	23/98 (23%)
		I-set	233..318	CDD:254352	23/98 (23%)
		Ig	<349..402	CDD:299845	13/95 (14%)
		IG_like	423..502	CDD:214653	13/78 (17%)
		Ig	435..498	CDD:143165	9/62 (15%)
		FN3	507..602	CDD:238020	5/22 (23%)
		fn3	614..696	CDD:278470
		PHA02666	1105..>1312	CDD:222914
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900