DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpr15 and Pxdn

DIOPT Version :9

Sequence 1:NP_001287299.1 Gene:dpr15 / 41473 FlyBaseID:FBgn0037993 Length:662 Species:Drosophila melanogaster
Sequence 2:NP_001258190.1 Gene:Pxdn / 554172 RGDID:1560694 Length:1475 Species:Rattus norvegicus


Alignment Length:703 Identity:141/703 - (20%)
Similarity:212/703 - (30%) Gaps:216/703 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LAKMPRRLILLALLIC----------------------------------LPAIRGQAEETSILN 33
            :|..|.|..||||::|                                  |.|:...|.:||||:
  Rat     1 MAVRPTRRCLLALVLCFAWWAMAVVASKQGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILD 65

  Fly    34 SNGTNGR-----AFQRTQSRREAL--------IPATT--------------QMAQTLDKASAFRP 71
            ......|     ||:|.::....|        ||:..              ...|::|: .||:.
  Rat    66 LRFNRIREIQPGAFRRLRNLNTLLLNNNQIKKIPSGAFEDLENLKYLYLYKNEIQSIDR-QAFKG 129

  Fly    72 TMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNV--------QEQHSYRIT 128
              .|:|:..       .:..|.|.....:..:....||...:.:||..        |.:...|:.
  Rat   130 --LASLEQL-------YLHFNQIETLDPESFQHLPKLERLFLHNNRITHLVPGTFSQLESMKRLR 185

  Fly   129 QDN------------ATSAASIAPNGTAFGDAPSIPIGVAPATTTTIDPATTTPTTTTRRTTRRP 181
            .|:            |....:.|.:|.            |.|..|...|         ||...|.
  Rat   186 LDSNALHCDCEILWLADLLKTYAQSGN------------AQAAATCEYP---------RRIQGRS 229

  Fly   182 VATTT-----LKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIA 241
            |||.|     .:.|....:.|.....:|...|..|..:...|..|.|||..:...:..|....:.
  Rat   230 VATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLL 294

  Fly   242 DQRFQSVFSPNPERWSLQIKYVQLKDEGTYEC---QVSTEPKASAIVHLRIVEP--KTELIGEST 301
            |.            .:|.|:..|..|||.|:|   .|:.|.|...:....:..|  .|.:|....
  Rat   295 DD------------GTLMIQNTQEADEGVYQCMAKNVAGEAKTHEVTLRYLGSPARPTFVIQPQN 347

  Fly   302 RHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEI---ERIDLP---------- 353
            ..|..|..|.|.|  |....|...|.|           .||.||.:   .|:::.          
  Rat   348 TEVLVGESVTLEC--SATGHPLPQITW-----------TRGDRTPLPIDPRVNITPSGGLYIQNV 399

  Fly   354 AEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQ 418
            |:..:...|...:.:..|...|......|.|..|.|..:......:|:                 
  Rat   400 AQSDSGEYTCFASNSVDSIHATAFIIVQALPQFTVTPQSRVVIEGQTV----------------- 447

  Fly   419 NDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGD 483
            :...|........:|.....:||..:......:|||...:|:.......|...|...|     |.
  Rat   448 DFQCEAKGYPQPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNII-----GS 507

  Fly   484 SAATA-ATTSAWLTTMDAEAAT--TAATTTTTMLPSSSFIK------------QITTAS------ 527
            ....| .|....:|.:.|...:  |....|...||.||..:            |:|.:.      
  Rat   508 QKVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISP 572

  Fly   528 ---LIIPAVVKLDSGNYTCSPSNS---APRTIVLHV------LNGE-YSASAI 567
               |.|..|...|:|.|.|...|:   |..::||.|      .||: |.|::|
  Rat   573 EGFLTINDVGTADAGRYECVARNTIGYASVSMVLSVNVPDVSRNGDPYVATSI 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr15NP_001287299.1 IG_like 197..289 CDD:214653 22/94 (23%)
V-set 204..290 CDD:284989 21/88 (24%)
PxdnNP_001258190.1 leucine-rich repeat 42..60 CDD:275380 3/17 (18%)
leucine-rich repeat 63..84 CDD:275380 6/20 (30%)
LRR_4 107..148 CDD:289563 8/50 (16%)
LRR_8 108..167 CDD:290566 11/68 (16%)
leucine-rich repeat 109..132 CDD:275378 4/25 (16%)
LRR_4 132..172 CDD:289563 7/46 (15%)
leucine-rich repeat 133..156 CDD:275378 3/29 (10%)
LRR_8 155..>192 CDD:290566 7/36 (19%)
leucine-rich repeat 157..180 CDD:275378 5/22 (23%)
leucine-rich repeat 181..193 CDD:275378 2/11 (18%)
TPKR_C2 189..240 CDD:301599 14/71 (20%)
Ig 243..330 CDD:299845 23/98 (23%)
I-set 243..330 CDD:254352 23/98 (23%)
I-set 339..426 CDD:254352 20/99 (20%)
Ig 343..426 CDD:299845 19/95 (20%)
I-set 430..516 CDD:254352 17/107 (16%)
Ig3_Peroxidasin 443..516 CDD:143222 14/94 (15%)
I-set 522..608 CDD:254352 20/85 (24%)
Ig4_Peroxidasin 539..607 CDD:143223 16/67 (24%)
An_peroxidase 738..1279 CDD:281139
peroxidasin_like 861..1300 CDD:188658
VWC 1411..1466 CDD:214564
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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