DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and Crtam

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001268883.1	Gene:	Crtam / 54698	MGIID:	1859822	Length:	393	Species:	Mus musculus

Alignment Length:	387	Identity:	73/387 - (18%)
Similarity:	126/387 - (32%)	Gaps:	93/387 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 PVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRF 245
            ||....||       .:|:..:.|....|.|...|.....:.|| ...|..:.::|...:...::
Mouse    13 PVQAAFLK-------METVTVEEGQTLTLTCVTSQTKNVSLQWL-APSGFTIFLNQHPALKSSKY 69

  Fly   246 QSVFSPNPERWSLQIKYVQLKDEGTYEC-----QVSTEPKASAIVHLRIVEPKTELIGESTRHVK 305
            | :...:..:.|:.:..|.|::||.|.|     .|.|: :....|.:...:|..|.:  ..|...
Mouse    70 Q-LLHHSATQLSISVSNVTLREEGVYTCLHYGSSVKTK-QVRVTVLVTPFQPTVEAL--VLRRQN 130

  Fly   306 AGSQVKLRCIISQALEPPLFINWFYNQ-KQIY--------------------------------- 336
            ....|.|:|...:: :||..|.|...: .:||
Mouse   131 GEKSVVLKCSTERS-KPPPQITWLLGEGLEIYGELNHEFEADGKICNTSSMLIARAYGKNSTVHC 194

  Fly   337 ------LHNRR-------------GWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPA 382
                  ||.|:             ...::.|..|.|.:...:|......|:|.|  ....|:.|.
Mouse   195 IIQHEGLHGRKLVAPFQFEDLVADQETSDQETSDAPEQSSLSSQALQQPTSTVS--MMENSSIPE 257

  Fly   383 T-----------PSTTATGSTEGATSSETLNGLVTIT----RSYILDAISQNDVSELGAAAGVAV 432
            |           |..:...|.:....:...:|::.:|    ..:||..|.|..:.:|..|..|..
Mouse   258 TDKEEKEHATQDPGLSTEASAQHTGLARRKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVVWK 322

  Fly   433 ATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAW 494
            .....:.|.|....:.|:...||:...   |:.|..:......||...:|  |.|..:...|
Mouse   323 KESEISEQALESYRSRSNNEETSSQEN---SSQAPQSKRCMNYITRLYSG--AKTKKSAQHW 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/96 (21%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	19/90 (21%)
Crtam	NP_001268883.1	Ig	22..112	CDD:299845	19/92 (21%)
		IG_like	22..112	CDD:214653	19/92 (21%)
		C2-set_2	119..205	CDD:285423	14/88 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..280		12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..356		5/25 (20%)
		PDZ-binding. /evidence=ECO:0000305\|PubMed:18329370	390..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12439
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000