DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Hmcn1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_006529820.1	Gene:	Hmcn1 / 545370	MGIID:	2685047	Length:	5658	Species:	Mus musculus

Alignment Length:	517	Identity:	111/517 - (21%)
Similarity:	172/517 - (33%)	Gaps:	148/517 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 KPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQ-RFQSVFSP 251
            :|||.|.....:....|..|.|.|.|...|...::|  .|.|..:.      :||. |.:::
Mouse   518 EPPPIIQLPNNVTVTPGERAVLACLVISAVDYNLTW--QRSGRDIR------LADSARIRTL--- 571

  Fly   252 NPERWSLQIKYVQLKDEGTYECQVSTE-PKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCI 315
              ...||:::.|::.|.|.|.|.||:| ..|:|.|.|.:.|.....:....:....||::.:.|.
Mouse   572 --ANLSLELRSVKIGDAGEYRCVVSSEGGSAAASVFLTVQEKPKVTVMPKNQSFTGGSEISIMCS 634

  Fly   316 ISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTST- 379
            .:...:|.  |.|..|:..| :.:.|...|....:.:...||..:.|.....:.|:.|...|||
Mouse   635 ATGYPKPK--IVWTMNEMFI-MGSHRYRMTSEGTLFIKNAVPKDAGTYACLASNAAGTDKQTSTL 696

  Fly   380 ---------TPATPSTTATGST---EGATSS-----------------------ETLNGLVTITR 409
                     ...:....|.|.|   |..||.                       :.|.||:.|..
Mouse   697 RYIEAPKLVVEQSELLVALGDTTVMECKTSGIPPPQVKWFKGDLELRPSTFLSIDPLVGLLKIQE 761

  Fly   410 SYILDAISQND-----VSELGAAAG------------------VAVATETSTA------------ 439
            :..|||   .|     ::|.|.|.|                  |||...::..
Mouse   762 TQDLDA---GDYTCVAINEAGRATGRLTLDVGSPPVFIQEPSDVAVEIGSNVTLPCYVQGYPEPK 823

  Fly   440 ---------QLLTEVEATSSTSGTSTGA----GLLASTSAAYAAGA-------AAGITTAATGDS 484
                     .:.:...:.|..|...|||    .|.||....|...|       .:..|...||..
Mouse   824 IKWRRLDNMPVFSRPFSVSFISQLRTGALFISNLWASDKGTYICEAENQFGKIQSQTTVTVTGLV 888

  Fly   485 AATAATTSAWLTTMDAEAATTAAT-------------TTTTMLPSSSFIKQITTASLIIPAVVKL 536
            |.....:.:..:.::.:..|...|             ..:.||..:.:|...:..||.|..|...
Mouse   889 APLIGISPSMASVIEGQPLTLPCTLLAGNPIPERRWMKNSAMLVQNPYITVRSDGSLHIERVRLQ 953

  Fly   537 DSGNYTCSPSNSA-----PRTIVLHVL----NGEY--------------SASAIKSGSVSWS 575
            |.|.|||..||.|     ..::.:|||    :|:.              .||.|...|::||
Mouse   954 DGGKYTCVASNVAGTNNKTTSVAVHVLPSIQHGQQILSTIEGVPVTLPCRASGIPKPSITWS 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	26/93 (28%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	26/87 (30%)
Hmcn1	XP_006529820.1	vWFA	42..198	CDD:238119
		Ig	520..608	CDD:386229	29/100 (29%)
		Ig	612..696	CDD:386229	17/86 (20%)
		I-set	702..789	CDD:369462	18/89 (20%)
		I-set	793..884	CDD:369462	14/90 (16%)
		Ig	890..977	CDD:386229	17/86 (20%)
		Ig	980..1071	CDD:386229	8/36 (22%)
		I-set	1085..1167	CDD:369462
		I-set	1171..1257	CDD:369462
		Ig	1266..1354	CDD:386229
		I-set	1368..1447	CDD:369462
		IG_like	1459..1541	CDD:214653
		Ig	1564..1632	CDD:386229
		I-set	1644..1728	CDD:369462
		I-set	1751..1821	CDD:369462
		Ig	1843..1935	CDD:319273
		Ig	1949..2031	CDD:386229
		Ig	2044..2115	CDD:386229
		I-set	2134..2214	CDD:369462
		I-set	2226..2309	CDD:369462
		Ig_3	2313..2390	CDD:372822
		Ig	2429..2491	CDD:319273
		I-set	2501..2590	CDD:369462
		I-set	2605..2686	CDD:369462
		I-set	2704..2785	CDD:369462
		Ig	2818..2881	CDD:319273
		I-set	2902..2983	CDD:369462
		I-set	3005..3075	CDD:369462
		I-set	3087..3170	CDD:369462
		Ig	3192..3260	CDD:319273
		Ig	3267..3361	CDD:386229
		I-set	3377..3453	CDD:369462
		I-set	3468..3546	CDD:369462
		IG_like	3558..3639	CDD:214653
		I-set	3652..3732	CDD:369462
		I-set	3736..3823	CDD:369462
		Ig	3846..3912	CDD:319273
		Ig	3937..4004	CDD:319273
		Ig	4028..4090	CDD:319273
		I-set	4102..4188	CDD:369462
		Ig	4209..4276	CDD:319273
		I-set	4283..4368	CDD:369462
		Ig	4387..4458	CDD:386229
		I-set	4463..4549	CDD:369462
		TSP1	4556..4607	CDD:214559
		TSP1	4612..4664	CDD:214559
		TSP1	4669..4721	CDD:214559
		TSP1	4726..4778	CDD:214559
		TSP1	4783..4835	CDD:214559
		TSP1	4840..4892	CDD:214559
		G2F	4891..5115	CDD:214774
		EGF_CA	5130..5169	CDD:214542
		EGF_CA	5170..5213	CDD:311536
		EGF_CA	5215..5252	CDD:214542
		EGF_CA	5253..5286	CDD:238011
		EGF_CA	5295..5336	CDD:311536
		EGF_CA	5338..5377	CDD:214542
		EGF_CA	5455..5494	CDD:214542
		EGF_CA	5495..5531	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910