DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and fgfrl1b

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001012263.2	Gene:	fgfrl1b / 497135	ZFINID:	ZDB-GENE-050201-3	Length:	481	Species:	Danio rerio

Alignment Length:	487	Identity:	94/487 - (19%)
Similarity:	150/487 - (30%)	Gaps:	161/487 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PPT----IDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFS 250
            ||:    :::.||  ::.|....:||.|:......:.|  ::||..:....:.:...:|
Zfish    25 PPSVSRPVENRQT--AKLGCTVRIPCPVEGDPPPLVLW--VKDGRNVNPGWSRYKVLKR------ 79

  Fly   251 PNPERWSLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIV----------------EPKTEL-IG 298
                  ||:||.|:|:|.|.|.|:|:....:.|:....||                ||..:| :.
Zfish    80 ------SLKIKEVELEDAGVYICRVTNGFGSLALNFTLIVIDDAAVPQNPPPPDAAEPNADLSLQ 138

  Fly   299 ESTRH--VK-----------------AGSQVKLRCIISQALEPPLFINWFYNQKQIYLHN----- 339
            |.||.  ||                 .||.|:|:|:.|.  .|...|.|:.:|.  .|.|
Zfish   139 EPTREPWVKPRFSQPTKMRRRVLEQPVGSSVRLKCLASG--NPTPVITWWKDQS--LLDNPQQSK 199

  Fly   340 RRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSETLNGL 404
            |..|...::.:.     |..|...|...:.|:.....|.....         .|...|...|.|.
Zfish   200 RPQWTLTLKNLQ-----PQDSAKYTCHVSNAAGHINATYKVDV---------IERTNSKPILTGT 250

  Fly   405 VTITRSYILDAISQNDVSELGAAAGVAVATETS---TAQLLTEVEATSSTSGTSTGAGLLASTSA 466
            ..:           |...|.|..|.......:.   ..|.|..|:..|.....|
Zfish   251 HPV-----------NTTVEFGGTASFQCKVHSDVKPVIQWLKRVDPGSEDRYNS----------- 293

  Fly   467 AYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIP 531
                      |....|.......|...|                  ..|..|::.::
Zfish   294 ----------TLEVGGQHYVVLPTGDVW------------------SRPDGSYLNKL-------- 322

  Fly   532 AVVKL---DSGNYTCSPSNS---APRTIVLHVLNGEYSASAIKSGSVS----WSALIGCHGYLHW 586
            |:||.   |:|.|.|..:|:   :.|:..|.||:.......:....:|    |..:||.
Zfish   323 AIVKARDEDAGMYICLGANTMGYSVRSAYLTVLSDPKVEKDVIPRHISPGLPWPLIIGI------ 381

  Fly   587 RNVSTLL----TLLWIIKFALARDICQPNATS 614
             ..:.||    .:||:......:....|..|:
Zfish   382 -PAAALLIVGTIVLWLCHSRRRQSALPPRPTT 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	22/91 (24%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	20/85 (24%)
fgfrl1b	NP_001012263.2	I-set	26..113	CDD:254352	23/102 (23%)
		IGc2	43..103	CDD:197706	18/73 (25%)
		Ig2_FGFRL1-like	158..237	CDD:143264	19/87 (22%)
		IG_like	165..237	CDD:214653	19/80 (24%)
		IG_like	252..354	CDD:214653	25/159 (16%)
		Ig	260..355	CDD:299845	23/141 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910