DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and NCAM1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	387	Identity:	88/387 - (22%)
Similarity:	135/387 - (34%)	Gaps:	107/387 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PPTIDDYQTII---SQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSP 251
            ||||...|.|:   :..|....|.|:.:...:..:||  .:||..:..::.    |:::  :||.
Human   211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW--TKDGEQIEQEED----DEKY--IFSD 267

  Fly   252 NPERWSLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCII 316
            :..:  |.||.|...||..|.|                       |.|:    |||.|
Human   268 DSSQ--LTIKKVDKNDEAEYIC-----------------------IAEN----KAGEQ------- 296

  Fly   317 SQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEV---PTTSTTTTTTTTTASTTTTTTS 378
                :..:.:..|...|..|:.|:.....| |::.|..|.   |..|.|..|:|...|:....:.
Human   297 ----DATIHLKVFAKPKITYVENQTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKASW 356

  Fly   379 TTPA-----TPSTTATGSTEGATSS-------ETLNGLVTI-----TRSYILDAISQNDVSELGA 426
            |.|.     .|.....|..:|...|       |||:|.:.:     ..|..|.:|...|..|...
Human   357 TRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 421

  Fly   427 AAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYA-AGAAAGITTAATGDSAATAAT 490
            .|...:..::.:..|  ||:......|          ..|.|. .|....||.    :..|..:.
Human   422 TASNTIGQDSQSMYL--EVQYAPKLQG----------PVAVYTWEGNQVNITC----EVFAYPSA 470

  Fly   491 TSAWLTTMDAEAATTAATTTTTMLPSSSF--IKQITTAS---LIIPAVVKLDSGNYTCSPSN 547
            |.:|.  .|.:           :||||::  ||...|.|   |.:....:.|.|||.|:..|
Human   471 TISWF--RDGQ-----------LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	20/94 (21%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	18/85 (21%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652
		Ig	211..307	CDD:325142	31/143 (22%)
		Ig	306..438	CDD:325142	30/134 (22%)
		Ig_3	447..519	CDD:316449	23/88 (26%)
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810