DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and MUSK

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens

Alignment Length:	322	Identity:	63/322 - (19%)
Similarity:	100/322 - (31%)	Gaps:	111/322 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AFQRTQSRREALIPATTQMAQTLDKASAFRPTMAAALDAAAPNRSS---NNVAIN------NISN 96
            ||..|:...:|  |..|...:|:|.......|...|:::......|   |.:.|.      :|..
Human    17 AFSGTEKLPKA--PVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRE 79

  Fly    97 NGDQRLRLTAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTT 161
            || |.|.:.:..::          :...|..|.:|..        |.|.....::.:.:.|
Human    80 NG-QLLTILSVEDS----------DDGIYCCTANNGV--------GGAVESCGALQVKMKP---- 121

  Fly   162 TIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLR- 225
                          :.||.|:....::               |..|.|||......|..:||::
Human   122 --------------KITRPPINVKIIE---------------GLKAVLPCTTMGNPKPSVSWIKG 157

  Fly   226 ---MRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYEC-------------- 273
               :|:...:.|                  .|..||:|..||.:|.|.|.|
Human   158 DSPLRENSRIAV------------------LESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVV 204

  Fly   274 ----QVSTEPKASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYN 331
                :..:||:....|..||      |....:.:|..||.|.|.|..:....|.  |.|..|
Human   205 KLEVEEESEPEQDTKVFARI------LRAPESHNVTFGSFVTLHCTATGIPVPT--ITWIEN 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/113 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	24/107 (22%)
MUSK	XP_005252051.1	I-set	28..117	CDD:254352	19/107 (18%)
		Ig	36..117	CDD:299845	17/99 (17%)
		I-set	121..203	CDD:254352	24/132 (18%)
		Ig	135..201	CDD:299845	20/83 (24%)
		I-set	223..306	CDD:254352	13/44 (30%)
		Ig	239..306	CDD:143165	7/22 (32%)
		CRD_FZ	325..467	CDD:295308
		PTKc_Musk	579..868	CDD:133181
		Pkinase_Tyr	585..866	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910