DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and Strn-Mlck

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster

Alignment Length:	682	Identity:	127/682 - (18%)
Similarity:	219/682 - (32%)	Gaps:	212/682 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IRGQAEETSILNSNGTNGRAFQRTQSRREALIPATTQ--MAQTLDKAS--AFRPTMAAALD---- 78
            ::.:||:|..|:       |.:.|....:.::|....  ..||.|..|  .::...:...|
  Fly  5236 VKNEAEKTDQLS-------AKKPTVLDEDLVVPKRKPYLAEQTADSISLQTYKSMDSEYKDRKES 5293

  Fly    79 AAAPNRSSNNVAINNISNNGDQRLRLTAAL---EANL--IMSNRNVQEQHSYRITQDNATSAASI 138
            .:|..:.:.::.:.|.:......|:||..|   |.|:  ...|..::....||.|.::..|...|
  Fly  5294 RSAKRKPTVDIQLTNRNTASGSDLKLTCGLSGHEMNVQWFKDNCPIENGAKYRRTLNDGLSCLEI 5358

  Fly   139 APNGTAFGDA------PSIPIG-VAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDDY 196
              .....||:      .|...| |..:...||..|.::...|.      |:.|..::     |.|
  Fly  5359 --KSAELGDSGIYRCIASNQNGEVETSCLVTIYEAPSSKFGTP------PIFTRNIR-----DAY 5410

  Fly   197 QTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIK 261
            .:    .|....|.|.|....|..|.|  .||..:|.::.|.:..:::...:       ..|.|.
  Fly  5411 HS----QGNQLTLECKVSGSPKPHIYW--QRDNTLLPIEGTKYQYEEQSDGI-------KLLTIN 5462

  Fly   262 YVQLKDEGTYECQVSTE---------PKASAIVHLRIVE--PKTELIGE---------------- 299
            .....|.|.|.|...:|         .:||..|..||.:  |..::|.|
  Fly  5463 NFGSNDSGLYTCYAESENGQMKISKFVQASDYVRERIADKKPIDKVIQEIKRDESSSAAANDTAA 5527

  Fly   300 ------------------STRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQI------YLHNR 340
                              .|..:.:|::.:|.|.::..:|.   ::|..|.:::      .::|.
  Fly  5528 AKAKAREAKLRLNLETSLKTMTIGSGNKAQLICYVTGIIED---VHWLRNDERVTKDARHKIYNI 5589

  Fly   341 RGWRTEIE----RIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATS--SE 399
            .| ...:|    |::...........:..|..:|...:....:|...|.:.::|..|....  :|
  Fly  5590 NG-AISLEIYDARVEDSGHYRCVVKNSRQTVESAGQLSVLDQSTGKLPESFSSGIIESYDDQRNE 5653

  Fly   400 TLNGLVTITR---SYILD--AISQN---DVSELGAAAGVAVATETST--------AQLLTEVEAT 448
            .:.....|.|   |::.|  :|..|   .:.|.|....:.:....|:        |:....:::|
  Fly  5654 IVLSCQVIGRPSVSWMRDDHSICNNRYRTIEEPGGVRKLVIRNPISSDCGIFACYAEHEDRIDST 5718

  Fly   449 SST------------------------------------SGT-----------------STGAG- 459
            |.|                                    ||:                 :.|.|
  Fly  5719 SITIKAADLKRLINVSQEEIPSIGDHESTPWSRSQSHLSSGSQVNGNGELHRAGDRVLRNVGKGK 5783

  Fly   460 -----LLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSF 519
                 ||...:.  :.||...:..:.:||.    .|...||.....             ||.|..
  Fly  5784 PLFHTLLHDRTV--SEGANLRLVCSVSGDE----NTHIEWLKNHKP-------------LPRSDN 5829

  Fly   520 IKQIT----TASLIIPAVVKLDSGNYTCSPSN 547
            ..|..    .|||.|.|.|..|||||||..:|
  Fly  5830 RYQTVYLNGEASLEIFAAVADDSGNYTCCATN 5861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	21/100 (21%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	22/94 (23%)
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352	18/89 (20%)
		IGc2	5313..5378	CDD:197706	15/66 (23%)
		IG	5412..5482	CDD:214652	18/82 (22%)
		IGc2	5413..5481	CDD:197706	18/76 (24%)
		I-set	5542..5627	CDD:254352	13/88 (15%)
		Ig	5556..5621	CDD:143165	10/68 (15%)
		Ig	5654..5721	CDD:143165	12/66 (18%)
		I-set	5784..5874	CDD:254352	27/97 (28%)
		IGc2	5797..5864	CDD:197706	25/82 (30%)
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910