DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and Igdcc4

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_038937673.1	Gene:	Igdcc4 / 363081	RGDID:	1310919	Length:	1345	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	104/530 - (19%)
Similarity:	171/530 - (32%)	Gaps:	159/530 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKMPRRLILLALLICLPAIRGQAEETSILNSNGTNGRAFQRTQSRR---EALIPATTQMAQTLDK 65
            |..|||          |..|.:|..:|:      .|...||.::..   |..:|..|.:..:.|:
  Rat    83 APFPRR----------PWTRLEAGRSSV------RGAGPQRPEAPELSGELPLPQETTVQLSCDE 131

  Fly    66 AS---AFRPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQEQHSYRI 127
            ..   ...|..|..||......::........|.:||      ..||.:    |.::....|.|:
  Rat   132 GPLRVVLGPEQAVVLDCTLGAAAAGPPTTVTWSKDGD------VVLERD----NLHLLPNGSLRL 186

  Fly   128 TQDNATSAASIAPNGTAFGDAPSI--------------PIGVAPATTTTIDPATTTPTTTTRRTT 178
                   ::.:.|..:...:|.|:              |:||..:....:..||
  Rat   187 -------SSPLEPEDSDDEEALSVWKVIEGSYSCLAHGPLGVVASQVAVVKLAT----------- 233

  Fly   179 RRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQ 243
               :...:|.|     :.|| :.:.|| |...|:.:.|....|:|.:         ||.|...:.
  Rat   234 ---LEDFSLHP-----ESQT-VEENGT-ARFECHTEGLPAPIITWEK---------DQVTVTEEP 279

  Fly   244 RFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPK------ASAIVHLR-------------I 289
            |.  :..||   ..|||..||..|.|:|.|..:...:      |...|.||             :
  Rat   280 RL--ITLPN---GVLQILDVQDSDAGSYRCVATNSARQRFSQEALLSVALRGSLEATRGQDVVIV 339

  Fly   290 VEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQ-------------------- 334
            ..|      |:|. |.:|..|.|.|:.|  .:|..|::|.....:
  Rat   340 AAP------ENTT-VVSGQSVVLECVAS--ADPTPFVSWVRQDGKPISTDVIVLGRTNLLIASAQ 395

  Fly   335 -----IYL-----HNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTAT 389
                 :|:     ...|.:.|....:.:.| .|..|......:.|.::|..........|..|..
  Rat   396 PRHSGVYVCRANKPRTRDFATAAAELRVLA-APAISQAPEALSRTRASTARFVCRASGEPRPTLH 459

  Fly   390 GSTEGA-------TSSETLNGLVTITRSYILDA-----ISQNDVSELGAAAGVAVATETSTAQLL 442
            ...:||       ...:...|.:.||:..:.|:     :::|......|||.:||..........
  Rat   460 WLHDGAPLRPNGRVKVQGGGGSLVITQIGLQDSGYYQCVAENSAGTACAAAPLAVVVREGLPSAP 524

  Fly   443 TEVEATSSTS 452
            |.|:||..:|
  Rat   525 TRVKATPLSS 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	28/110 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	26/104 (25%)
Igdcc4	XP_038937673.1	Ig	131..223	CDD:416386	18/108 (17%)
		Ig strand A'	135..138	CDD:409353	0/2 (0%)
		Ig strand B	144..154	CDD:409353	2/9 (22%)
		Ig strand C	160..165	CDD:409353	0/4 (0%)
		Ig strand C'	167..169	CDD:409353	2/7 (29%)
		Ig strand D	175..179	CDD:409353	1/3 (33%)
		Ig strand E	182..187	CDD:409353	2/11 (18%)
		Ig strand F	209..217	CDD:409353	0/7 (0%)
		Ig_3	237..308	CDD:404760	26/91 (29%)
		Ig strand A'	243..246	CDD:409353	2/3 (67%)
		Ig strand B	252..259	CDD:409353	2/6 (33%)
		Ig strand C	265..270	CDD:409353	2/4 (50%)
		Ig strand C'	272..274	CDD:409353	1/1 (100%)
		Ig strand D	280..284	CDD:409353	1/5 (20%)
		Ig strand E	287..292	CDD:409353	2/4 (50%)
		Ig strand F	300..308	CDD:409353	3/7 (43%)
		Ig strand G	316..324	CDD:409353	2/7 (29%)
		IG_like	342..423	CDD:214653	15/89 (17%)
		Ig strand A'	342..347	CDD:409353	3/11 (27%)
		Ig strand B	353..360	CDD:409353	3/6 (50%)
		Ig strand C	366..371	CDD:409353	2/4 (50%)
		Ig strand C'	373..375	CDD:409353	0/1 (0%)
		Ig strand D	381..384	CDD:409353	0/2 (0%)
		Ig strand E	387..393	CDD:409353	0/5 (0%)
		Ig strand F	400..407	CDD:409353	1/6 (17%)
		Ig	442..514	CDD:416386	13/71 (18%)
		Ig strand B	443..451	CDD:409353	1/7 (14%)
		Ig strand C	457..462	CDD:409353	1/4 (25%)
		Ig strand C'	464..467	CDD:409353	2/2 (100%)
		Ig strand D	472..476	CDD:409353	0/3 (0%)
		Ig strand E	478..485	CDD:409353	1/6 (17%)
		Ig strand F	494..501	CDD:409353	0/6 (0%)
		Ig strand G	505..514	CDD:409353	3/8 (38%)
		fn3	522..607	CDD:394996	5/13 (38%)
		FN3	619..712	CDD:238020
		fn3	724..818	CDD:394996
		FN3	842..934	CDD:238020
		FN3	942..1034	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910