DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpr15 and LRIT3

DIOPT Version :9

Sequence 1:NP_001287299.1 Gene:dpr15 / 41473 FlyBaseID:FBgn0037993 Length:662 Species:Drosophila melanogaster
Sequence 2:NP_940908.3 Gene:LRIT3 / 345193 HGNCID:24783 Length:679 Species:Homo sapiens


Alignment Length:423 Identity:98/423 - (23%)
Similarity:155/423 - (36%) Gaps:121/423 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 AAPN---RSSNNVAINNISNNGDQRLRLTAA----LEA--NLIMSNRNVQEQHSYRI---TQDNA 132
            :.||   |...|:|..::|:|     |||..    ||:  :|:.:...|.:....||   .|||.
Human   143 SVPNEALRYLKNLAYLDLSSN-----RLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNP 202

  Fly   133 TSAASIAPNGTAFGD---APSIPIG--VAPATTTTIDPATT--TPTTTTRRTTRRPVATTTLKPP 190
            .           |.|   :..|.:.  |.|| ...:||..|  .|...|....:|......|| |
Human   203 W-----------FCDCHISKMIELSKVVDPA-IVLLDPLMTCSEPERLTGILFQRAELEHCLK-P 254

  Fly   191 PTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPE- 254
            ..:.....|:|..|::..|.|:........|:|.|....   .|:.|          |...:|| 
Human   255 SVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSS---PVNYT----------VIQESPEE 306

  Fly   255 --RWS-LQIKYVQLKDEGTYECQV-STEPKASAIVHLRI-------VEPKT-ELIGESTR-HVKA 306
              ||| :.:..:..||.|.|:|:. :....:.|:|.:.:       :.|.| |..|:... .|:.
Human   307 GVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPEWDVQP 371

  Fly   307 GSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTT--TT 369
            ||.....  :|.|              ..||     |.:...        ||:|.:.:|.:  :|
Human   372 GSGRSTS--VSSA--------------SSYL-----WSSSFS--------PTSSFSASTLSPPST 407

  Fly   370 AS------TTTTTTSTTPATPSTTATGSTEGATSSE-------------TLNGL----VTITRSY 411
            ||      :::|.:|||  |.||:.:.||..|....             ..||.    .:.::..
Human   408 ASFSLSPFSSSTVSSTT--TLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPASTSKKE 470

  Fly   412 ILDAISQNDVSELGAA-AGVAVATETSTAQLLT 443
            .|..:.|..::|..|| ..:.|.:||..:..||
Human   471 ELALLDQTMLTETNAAIENLRVVSETKESVTLT 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr15NP_001287299.1 IG_like 197..289 CDD:214653 23/96 (24%)
V-set 204..290 CDD:284989 21/97 (22%)
LRIT3NP_940908.3 LRR 1 56..79
leucine-rich repeat 59..82 CDD:275378
LRR_8 61..117 CDD:290566
LRR 2 80..103
leucine-rich repeat 83..106 CDD:275378
LRR 3 104..128
LRR_8 105..165 CDD:290566 7/26 (27%)
LRR_4 105..146 CDD:289563 0/2 (0%)
leucine-rich repeat 107..130 CDD:275378
LRR 4 129..151 2/7 (29%)
LRR_4 131..170 CDD:289563 10/31 (32%)
leucine-rich repeat 131..154 CDD:275378 3/10 (30%)
LRR 5 152..175 8/27 (30%)
leucine-rich repeat 155..168 CDD:275378 6/17 (35%)
Ig 267..345 CDD:299845 21/90 (23%)
IG_like 267..345 CDD:214653 21/90 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..375 7/23 (30%)
FN3 486..550 CDD:214495 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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