DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and dpr3

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	124/592 - (20%)
Similarity:	191/592 - (32%)	Gaps:	235/592 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LILLALLICLPAIRGQAEETSIL-------------------NSNGTNGRAFQRTQSRREALIPA 55
            :|::||::.:.    |.::.|:|                   :.:|.....|..:...:....||
  Fly   105 IIIMALVVSIM----QQQQQSLLWPFCNGLAAAAASTGQPDDSGDGPTLSTFLSSSQSQSPSPPA 165

  Fly    56 TTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNVQ 120
            .:..|.:....|:|  .:|......|.|.:..::|..:.|...|    |.|..:|....|....:
  Fly   166 ASASASSPSSFSSF--AVAHGPQTEATNHTFKSLAFLDASFGSD----LFAQTDAKRERSGAADE 224

  Fly   121 EQHSYRITQDNATSAASIAPNGTAFGDAPSIPI---GVAPATTTTIDPATTTPTTTTRRTTRRPV 182
            |      :||..||              .|:||   |:              |...|.||
  Fly   225 E------SQDADTS--------------QSLPIFDFGM--------------PRNITGRT----- 250

  Fly   183 ATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQS 247
                                ..|.|.:.|.|..|..|.:||:|.||.|||||...|:.:|:|||.
  Fly   251 --------------------GHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQV 295

  Fly   248 VFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIVE----PKTELIGESTRHVKAGS 308
            ..|.:...|:|.:|....||.|.|||||:||||.|....|.|:|    .|..:.|....|.||||
  Fly   296 TESKDSREWTLHVKAPLAKDSGIYECQVNTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGS 360

  Fly   309 QVKLRCIISQA----LEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTT 369
            .:.|.|::.|.    :.|   |.|:..:..|         |..:..|...|:|
  Fly   361 AIILNCLVQQPSVKDIGP---IYWYRGEHMI---------TPFDADDGQPEIP------------ 401

  Fly   370 ASTTTTTTSTTPATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQNDVSELGAAAGVAVAT 434
                                     |...|...|                            :..
  Fly   402 -------------------------AGRGEHPQG----------------------------IPE 413

  Fly   435 ETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMD 499
            :||...:::||:...                                 :.|...|..|....|:.
  Fly   414 DTSPNDIMSEVDLQM---------------------------------EFATRIAMESQLGDTLK 445

  Fly   500 AEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNSAPRTIVLHVLNGEYSA 564
            :....:.|.||                          |:|||||.|:.::..::::||:|.|..|
  Fly   446 SRLRISNAQTT--------------------------DTGNYTCQPTTASSASVLVHVINDENPA 484

  Fly   565 SAIKSGS 571
            :..|||:
  Fly   485 AMQKSGA 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	39/91 (43%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	39/85 (46%)
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	41/111 (37%)
		IG_like	243..329	CDD:214653	40/110 (36%)
		Ig	350..464	CDD:299845	36/249 (14%)
		IG_like	<441..477	CDD:214653	11/61 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444694
Domainoid	1	1.000	42	1.000	Domainoid score	I12424
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000207
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23279
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840