DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Sdk1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	785	Identity:	159/785 - (20%)
Similarity:	240/785 - (30%)	Gaps:	269/785 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLICLPA---------IRGQAEETSILNSNGTNGRAFQRTQSRREALIPATTQMAQTLDKASAFR 70
            :|.||..         ||..:|.|:.              .|..:.:||:    .|.|| |..:|
Mouse   105 VLTCLAEGSWPLEFKWIRNDSELTTY--------------SSEYKYIIPS----LQKLD-AGFYR 150

  Fly    71 PTMAAALDAAAPNRSSNNVAINNISNNGDQR---------------------------------- 101
            ..:...:.|....:|...||......:.|||
Mouse   151 CVVRNRMGALLQRKSEIQVAYMGNFMDTDQRKTVSQGHAALLNLLPIVSCPQPQVTWFREGHKII 215

  Fly   102 --LRLTAALEANLIMSNRNVQEQHSYRI------TQDNATSA---ASIA-PNGTAFGDAPSIPIG 154
              .|:...||..|::......:..:|.:      ..:|.||.   .|:| ..||....||.|.
Mouse   216 PSSRIAITLENQLVILATTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPIIV-- 278

  Fly   155 VAPATTTTIDPATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKK 219
            |||...:.:  |.::.||.......|||...::.     .....:...:|.|:|
Mouse   279 VAPGNRSVV--AGSSETTLECIANARPVEELSVH-----WKRNGVRLTSGLHSY----------- 325

  Fly   220 PISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQV----STEPK 280
                     |..||:...|                          ..|.|.|.|:.    ||...
Mouse   326 ---------GRRLTITNPT--------------------------SADTGMYVCEATLRGSTFEP 355

  Fly   281 ASAIVHLRIV-------EPKTELIGESTRHVKAGSQVKLRCIISQALEPPL-FINWF-------- 329
            |.|...|.|:       ||::.::||      ....:.:.|   :|:..|| .:.|:
Mouse   356 ARARAFLSIIEPPYFTAEPESRILGE------VEETMDIPC---RAMGVPLPTLQWYKDAVPLSK 411

  Fly   330 --------------YNQK---------QIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTAS 371
                          :.||         |.:..|..|            ||.|.:....|....|.
Mouse   412 LQNPRYKVLPSGGLHIQKLSPEDSGIFQCFASNEGG------------EVQTHTYLDVTNIAPAF 464

  Fly   372 T----TTTTTSTTPATPSTTATGSTEGATSSETLN-----GLVTITRSYILDA----ISQNDVSE 423
            |    .||.|....|......:|:.:.|.:.:..|     |.|.|.|..:|::    |:...:.:
Mouse   465 TQRPVDTTVTDGMTAVLRCEVSGAPKPAITWKRGNHILASGSVRIPRFMLLESGGLRIAPVFIQD 529

  Fly   424 LGAAAGVAVATETS--TAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAA 486
            .|.....|..||.|  .:.:||....||......... ::..|:|....|        ||.|
Mouse   530 AGNYTCYAANTEASVNASAMLTVWNRTSIVHPPEDRV-VIKGTTATLCCG--------ATHD--- 582

  Fly   487 TAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTC---SPSNS 548
             ..|:..::...|....|.:         |||.|......||:|......|.|:|||   |...|
Mouse   583 -PRTSLRYVWKKDNVVITAS---------SSSRIVVEKDGSLVISQTWSGDIGDYTCEIISEGGS 637

  Fly   549 APRTIVLHVL-------NGEYSASAIKSGSVSWSALIGCHG------YL------------HWRN 588
            ..||..|.|:       |...|.|..:|.||:.|.:....|      |:            |..|
Mouse   638 DSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPVLYYIVQVSENNSPWKVHLSN 702

  Fly   589 VSTLLTLLWIIKFALARD----ICQPNATSKA--TTRTSLLRAGDGATADVTRETGPKSGASFHR 647
            |...:|.:.:.....||.    :|..|...|.  :|.||.|...:...:     ..||:..:..|
Mouse   703 VGPEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYSTETSRLMLPEEPPS-----APPKNIVASGR 762

  Fly   648 VSSSI 652
            .:.||
Mouse   763 TNQSI 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	16/95 (17%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	16/89 (18%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606	17/82 (21%)
		IG_like	100..169	CDD:214653	17/82 (21%)
		IG_like	183..263	CDD:214653	8/79 (10%)
		Ig	197..247	CDD:299845	5/49 (10%)
		IG_like	281..357	CDD:214653	20/128 (16%)
		IGc2	294..347	CDD:197706	15/103 (15%)
		I-set	368..457	CDD:254352	17/109 (16%)
		Ig	388..454	CDD:143165	13/80 (16%)
		I-set	462..552	CDD:254352	21/89 (24%)
		Ig	476..552	CDD:299845	16/75 (21%)
		I-set	557..646	CDD:254352	27/110 (25%)
		Ig	562..646	CDD:299845	26/105 (25%)
		FN3	650..741	CDD:238020	19/90 (21%)
		fn3	753..839	CDD:278470	5/15 (33%)
		FN3	854..949	CDD:238020
		FN3	954..1036	CDD:238020
		FN3	1052..1148	CDD:238020
		FN3	1158..1253	CDD:238020
		FN3	1261..1349	CDD:238020
		FN3	1360..1453	CDD:238020
		FN3	1459..1554	CDD:238020
		FN3	1562..1676	CDD:238020
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810