DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Fas2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	121/597 - (20%)
Similarity:	184/597 - (30%)	Gaps:	197/597 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 QDNATSAASIAPNG---------TAFGD-------APSIPIG------VAPATTTTIDPATTTPT 171
            :||..:.....|||         |..|:       :.|:.:|      .:.|.|..::...|..|
  Fly    70 KDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKT 134

  Fly   172 TTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQ 236
            .         ||.|....|.  :.|.|:    |....:.|.||......|.|||..|....|.|
  Fly   135 Y---------VAITWTNAPE--NQYPTL----GQDYVVMCEVKADPNPTIDWLRNGDPIRTTND- 183

  Fly   237 TTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKASAIVHLRIVEPKTELIGEST 301
                     :.|...|    .|.|:.||..|||.|.|:.:            ::|     .||
  Fly   184 ---------KYVVQTN----GLLIRNVQESDEGIYTCRAA------------VIE-----TGE-- 216

  Fly   302 RHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTT 366
                         ::.:.:...:||                   :.|.|.||     |:......
  Fly   217 -------------LLERTIRVEVFI-------------------QPEIISLP-----TNLEAVEG 244

  Fly   367 TTTASTTTTTTSTTP-------ATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQNDVSEL 424
            ...|:..|......|       ||....|| :.....:.:|  |||||:      ::||:|....
  Fly   245 KPFAANCTARGKPVPEISWIRDATQLNVAT-ADRFQVNPQT--GLVTIS------SVSQDDYGTY 300

  Fly   425 GA----AAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSA 485
            ..    .|||..........:..::....:.:|..|               ....||..|.| ..
  Fly   301 TCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGART---------------KEIAITCRAKG-RP 349

  Fly   486 ATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNSAP 550
            |.|.|...|.|..:.............:.|:....:..:|.:|.|....:.|.|.|.|...|.
  Fly   350 APAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNK-- 412

  Fly   551 RTIVLHVLNGEYSASAIKSGSVSWSALIGCHGYLHWRNVSTLLTLLWIIKFA----LARDICQPN 611
                        .|.|.|:|.::   :.....:.|.:.:..:.:  |..:.|    ||..|  ||
  Fly   413 ------------GADAYKTGHIT---VEFAPDFSHMKELPPVFS--WEQRKANLSCLAMGI--PN 458

  Fly   612 AT---------SKATTRTSLLRAGDGATAD-----VTRE--TGPK------SGASFH-------R 647
            ||         .|....|:|...|.|..:|     |||:  :|.|      .|.:.|       |
  Fly   459 ATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEAR 523

  Fly   648 VSSSISATKVAE 659
            |...:|..|.::
  Fly   524 VPDFVSEAKPSQ 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	23/91 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	22/85 (26%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	12/62 (19%)
		IG_like	144..226	CDD:214653	28/133 (21%)
		IGc2	152..209	CDD:197706	22/70 (31%)
		I-set	230..319	CDD:254352	24/102 (24%)
		IGc2	243..309	CDD:197706	16/74 (22%)
		IG_like	330..424	CDD:214653	24/126 (19%)
		IGc2	339..412	CDD:197706	17/73 (23%)
		Ig	447..518	CDD:143165	21/72 (29%)
		fn3	534..611	CDD:278470	0/2 (0%)
		FN3	640..735	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900