DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and l1camb

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_571458.1	Gene:	l1camb / 30656	ZFINID:	ZDB-GENE-980526-512	Length:	1269	Species:	Danio rerio

Alignment Length:	771	Identity:	148/771 - (19%)
Similarity:	252/771 - (32%)	Gaps:	249/771 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 FRPTMAAALDAAAPNRSSNNV--AINNISNNG---DQRLRLTAALEANLIMSNRNVQEQHSYR-- 126
            :.|.....||..|....:.|:  :||.:..:|   |.|.|:::   ..||:||....:...|:
Zfish   349 YAPGETVRLDCQADGIPAPNITWSINGVPVSGTDVDPRRRVSS---GKLILSNVEFSDTAVYQCE 410

  Fly   127 -----------------------ITQD----NATSAASIAPNGTAFGD---------APSIP--- 152
                                   :|.|    .||:..::..:...||.         ..|||
Zfish   411 AVNKHGSILINTHVHVVELPAQILTPDERLYQATAGQTVMLDCRTFGSPLPKIHWEILDSIPALS 475

  Fly   153 -IGVAPATTTTIDPATTTPTTTTRRT-----TRRPVAT-------TTLKPPPTIDDYQTIISQAG 204
             ..::..|..::..:..:...:.|.|     |.:.::.       |.:..||     |.:....|
Zfish   476 NAKISQMTNGSLKISNVSEEDSNRYTCSVSETNKSISAELEVLNRTKIVGPP-----QNLHVIRG 535

  Fly   205 THAYLPC--NVKQLVKKP-ISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLK 266
            :.|.|.|  .|...:|.| :.|  .:|||.:|..    .::.::..:      ..||::..||::
Zfish   536 SDAILHCKYTVDHNLKSPTVQW--KKDGHKITAS----TSNDKYHEI------EGSLKVLDVQME 588

  Fly   267 DEGTYECQVST-------------EPKASAIVHLRIVE------------------PKTELI--- 297
            |.|.|.|.|||             :.|......|::.|                  |.||.:
Zfish   589 DMGIYSCGVSTTLDSDTASGYITVQDKPDPPQSLKLSEKMERSVTISWMPSVENNSPVTEYVIEM 653

  Fly   298 --GESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERID-----LPAE 355
              ||:.   ..|...|.|. :||.:          .|.:|:|.....:..:|..::     .|:|
Zfish   654 NEGETP---DEGQWQKYRS-VSQDI----------RQLEIHLQPYSKYHFQIRAVNSIGTSAPSE 704

  Fly   356 VPTTSTTTTTTTTTASTTTTTTSTTPAT--------------------------PSTTATGSTEG 394
            ...:.:|.............|.||.|.:                          .:.:....||.
Zfish   705 SSLSYSTPAAKPDRNPENVMTLSTDPKSMIISWQEMDRRQFNGPGFQYKVFWRRAADSGAHWTES 769

  Fly   395 ATSSETLNGLVTITRSYILDAISQNDVSELGAA---------AGVAVATETSTAQLLTEVEATS- 449
            :.|:..|  ||..|.:::...|....|::||||         :|.....|..:|..:||::.||
Zfish   770 SVSNPPL--LVNNTGTFVSFEIKVQAVNDLGAAPEPLTVIGYSGEDFPLEAPSALSVTELQKTSV 832

  Fly   450 ----------STSGTSTGAGL---LASTSAAYAAGAAAGITTAATGDSAATAA------------ 489
                      |..|...|..:   :...|....||.:..:......:..|.||
Zfish   833 MVRWSPVRPESVRGHLLGYKIYLRMKGPSGRLRAGRSPAVGNPTVIEVPADAAEKIVSDLQYYSD 897

  Fly   490 ---TTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNS--- 548
               |.:|:.:..:...:..::.:|....|.         ..|.:|    .|      |||.|
Zfish   898 YTLTITAFNSKGEGPHSEESSFSTPEGAPG---------PVLFLP----FD------SPSESEIT 943

  Fly   549 ----APRTIVLHVLNGEYSASAIKSGSVSWSALIGCHGYLHWRNVSTLLTLLWIIKFALARDICQ 609
                ||     |..|||.....::...|    :||.....|..::.    |..:.:|.|.....:
Zfish   944 LRWEAP-----HKPNGEIRGYLLQYQEV----VIGSESPQHVESID----LPAVTEFTLKNLNPE 995

  Fly   610 PNATSKATTRTSLLRAGDGATADVTRET----GPKSGASFHRVSSSISATKVAEDK 661
            ...|...:.|.|   |||||.|..:..|    .|.|..:.....:|::.:.|..|:
Zfish   996 SRYTFHLSARNS---AGDGAPAIQSGATLLDGEPPSVINMTAGETSVNLSWVPGDR 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	26/107 (24%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	25/101 (25%)
l1camb	NP_571458.1	Ig	69..133	CDD:299845
		Ig	140..231	CDD:299845
		IG_like	255..334	CDD:214653
		Ig3_L1-CAM	265..335	CDD:143284
		IG_like	344..426	CDD:214653	16/79 (20%)
		Ig	352..427	CDD:299845	15/77 (19%)
		IG_like	441..517	CDD:214653	11/75 (15%)
		IGc2	446..505	CDD:197706	8/58 (14%)
		I-set	522..607	CDD:254352	26/101 (26%)
		IGc2	535..595	CDD:197706	19/71 (27%)
		FN3	616..706	CDD:238020	18/103 (17%)
		FN3	719..798	CDD:214495	13/80 (16%)
		FN3	817..921	CDD:238020	17/103 (17%)
		FN3	926..1014	CDD:238020	29/122 (24%)
		FN3	1025..>1095	CDD:238020	5/24 (21%)
		Bravo_FIGEY	1148..1233	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910