DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	660	Identity:	129/660 - (19%)
Similarity:	202/660 - (30%)	Gaps:	212/660 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 QRLRL-TAALEANLIMSNRNVQEQHSYRITQDNATSAASIAPNGTAFGDAPSIPIGVAPATTTTI 163
            ||:.| ...:.:.|.:.|.|:::...||.   .||.|.                 |.....|..:
  Rat    65 QRVMLQKEGVRSRLTIYNANIEDAGIYRC---QATDAK-----------------GQTQEATVVL 109

  Fly   164 DPATTTPTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRD 228
            :        ..::.|.|.|    |.|..         .:.|..|.:.|.|.......:|||...
  Rat   110 E--------IYQKLTFREV----LSPQE---------FKQGEDAEVVCRVSSSPAPAVSWLYHN- 152

  Fly   229 GHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVSTEPKAS-------AIVH 286
                  ::.|.|.|.|| :|.:.|    :|||..:...|||.|.|:...|.:..       .||:
  Rat   153 ------EEVTTIPDNRF-AVLANN----NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN 206

  Fly   287 L--RIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNR---RGWRTE 346
            :  .||.|:......:.|    |.::.|.|..|.:.:|.  |:||.|.|.|..:.:   :|..||
  Rat   207 VPPAIVMPQKSFNATAER----GEEMTLTCKASGSPDPA--ISWFRNGKLIEENEKYILKGSNTE 265

  Fly   347 I---------------------------ERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATP 384
            :                           ..:.:..:.........||:.....|....:.....|
  Rat   266 LTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLICEAEGEPVP 330

  Fly   385 STTATGSTEGATSSE---TLNGLVTITRSYILDAISQNDV--SELGAAAGVAVATETSTAQLLTE 444
            ..|...:.:|.|.||   :.:|.:.:...:...::...||  |:.|.                .:
  Rat   331 EITWKRAIDGVTFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGR----------------YD 379

  Fly   445 VEATSSTSGTSTGAGL-------LASTSAAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEA 502
            .||.|...|......|       ..|....|.:.....|..:.  |..|....:..|    ..|.
  Rat   380 CEAASRIGGHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISC--DVKANPPASIHW----RREK 438

  Fly   503 ATTAATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSN-----------------SAP 550
            ....|..||.:...|...|.|    |.|......|.|.|.|:.:|                 |:|
  Rat   439 LVLPAKNTTHLKTHSVGRKMI----LEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSP 499

  Fly   551 RTIVLHVLN-------------------GEYSASAIKSGSVSWSALIGCHGYLHWRNVSTLLTLL 596
            |.:.:..|:                   ..|.....:..|.:|. ::..||      |.|.:.|
  Rat   500 RGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVTSETWK-IVRSHG------VQTTVVL- 556

  Fly   597 WIIKFALARDICQPNATSKATTRTSLLRA---GDGATADV-----TRETG-------PKSGASFH 646
                     ...:||.|.:  .|.:.:..   ||.:..::     .||..       |.||.||
  Rat   557 ---------SSLEPNTTYE--VRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF- 609

  Fly   647 RVSSSISATK 656
                .||.||
  Rat   610 ----KISITK 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/100 (25%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	25/94 (27%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452	13/75 (17%)
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452	1/3 (33%)
		Ig strand F	90..95	CDD:409452	2/7 (29%)
		Ig strand G	104..107	CDD:409452	0/2 (0%)
		IGc2	128..189	CDD:197706	22/72 (31%)
		Ig strand B	130..139	CDD:409353	2/8 (25%)
		Ig strand C	145..153	CDD:409353	3/14 (21%)
		Ig strand C'	156..159	CDD:409353	1/2 (50%)
		Ig strand D	162..167	CDD:409353	3/5 (60%)
		Ig strand E	168..175	CDD:409353	4/10 (40%)
		IgI_1_MuSK	209..298	CDD:409562	18/94 (19%)
		Ig strand B	228..232	CDD:409562	1/3 (33%)
		Ig strand C	241..245	CDD:409562	1/5 (20%)
		Ig strand E	264..268	CDD:409562	2/3 (67%)
		Ig strand F	278..283	CDD:409562	0/4 (0%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	19/112 (17%)
		Ig strand A	300..305	CDD:409353	0/4 (0%)
		Ig strand A'	309..313	CDD:409353	1/3 (33%)
		Ig strand B	317..325	CDD:409353	1/7 (14%)
		Ig strand C	331..337	CDD:409353	1/5 (20%)
		Ig strand C'	340..343	CDD:409353	1/2 (50%)
		Ig strand D	353..359	CDD:409353	0/5 (0%)
		Ig strand E	362..368	CDD:409353	0/5 (0%)
		Ig strand F	376..384	CDD:409353	3/23 (13%)
		Ig strand G	387..397	CDD:409353	2/9 (22%)
		Ig_3	401..479	CDD:404760	19/87 (22%)
		Ig strand B	418..422	CDD:409353	1/3 (33%)
		Ig strand C	431..435	CDD:409353	1/7 (14%)
		Ig strand E	458..462	CDD:409353	2/7 (29%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	18/110 (16%)
		fn3	594..678	CDD:394996	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900