DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr15 and LRIG1

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_056356.2	Gene:	LRIG1 / 26018	HGNCID:	17360	Length:	1093	Species:	Homo sapiens

Alignment Length:	392	Identity:	81/392 - (20%)
Similarity:	121/392 - (30%)	Gaps:	110/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PATTQMAQTLDKASAFRPTMAAALDAAAP--------NRSSNNVAINNI----SNNGDQRLRLTA 106
            |.||......|    .|.|.:||..:::|        |....|..:.|.    :.:|:
Human   501 PETTMAMVGKD----IRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE------- 554

  Fly   107 ALEANLIMSNRNVQEQHSYRITQDNATSAASIAPN--GTAFGDAPSIPIGVAPATTTTIDPATTT 169
            .:|...|:..|.|...|..|.        ..:..|  |:.:.....:.:.|.|:       .|.|
Human   555 VMEYTTILHLRQVTFGHEGRY--------QCVITNHFGSTYSHKARLTVNVLPS-------FTKT 604

  Fly   170 PTTTTRRTTRRPVATTTLKPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDG----- 229
            |...|.|||                          |.|.|.|.........|:|  .:||
Human   605 PHDITIRTT--------------------------TMARLECAATGHPNPQIAW--QKDGGTDFP 641

  Fly   230 -------HILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQV-STEPKASAIVH 286
                   |::..|...||.|                    |::.|.|.|.|.. ::....||...
Human   642 AARERRMHVMPDDDVFFITD--------------------VKIDDAGVYSCTAQNSAGSISANAT 686

  Fly   287 LRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERI- 350
            |.::|..:.::....|.|..|..|.|:|  .....||..|.||...:.:.|..|.....:.:.:
Human   687 LTVLETPSLVVPLEDRVVSVGETVALQC--KATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLV 749

  Fly   351 --DLPAEVPTTSTTTTTTTTTASTTTTTTSTTPAT----PSTTATGSTEGATSSETLNGLVTITR 409
              ::.||.....|...:.|.......:..|..||.    ..||....|....||..|..||.:..
Human   750 VQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCI 814

  Fly   410 SY 411
            .|
Human   815 IY 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	21/104 (20%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/98 (21%)
LRIG1	NP_056356.2	leucine-rich repeat	51..69	CDD:275380
		LRR_RI	<53..176	CDD:238064
		leucine-rich repeat	70..93	CDD:275380
		LRR_8	71..127	CDD:290566
		leucine-rich repeat	117..140	CDD:275378
		LRR_RI	131..416	CDD:238064
		LRR_8	140..223	CDD:290566
		leucine-rich repeat	141..164	CDD:275380
		leucine-rich repeat	165..197	CDD:275380
		LRR_8	211..271	CDD:290566
		leucine-rich repeat	213..236	CDD:275380
		leucine-rich repeat	237..260	CDD:275380
		LRR_8	259..319	CDD:290566
		leucine-rich repeat	261..284	CDD:275380
		leucine-rich repeat	285..308	CDD:275380
		LRR_8	308..367	CDD:290566
		leucine-rich repeat	309..332	CDD:275380
		leucine-rich repeat	333..356	CDD:275380
		leucine-rich repeat	357..381	CDD:275380
		LRR_8	383..442	CDD:290566
		leucine-rich repeat	384..405	CDD:275380
		leucine-rich repeat	408..431	CDD:275380
		LRRCT	442..490	CDD:214507
		I-set	495..595	CDD:254352	21/112 (19%)
		Ig	512..586	CDD:143165	17/88 (19%)
		I-set	599..689	CDD:254352	29/144 (20%)
		Ig_1	616..690	CDD:143240	20/95 (21%)
		I-set	693..780	CDD:254352	17/88 (19%)
		IGc2	707..770	CDD:197706	15/64 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910