DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr15 and MXRA5

DIOPT Version :9

Sequence 1:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_056234.2	Gene:	MXRA5 / 25878	HGNCID:	7539	Length:	2828	Species:	Homo sapiens

Alignment Length:	745	Identity:	131/745 - (17%)
Similarity:	217/745 - (29%)	Gaps:	241/745 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELAKMPRRLILLALLICLPAIRGQAEETSILNSNGTNGRAFQRTQSRR------------EALIP 54
            :|.::|.:.||....:.||.:..|:.           .|.|..:||.|            ...:|
Human  1604 QLTRVPAKPILPTATVRLPEMSTQSA-----------SRYFVTSQSPRHWTNKPEITTYPSGALP 1657

  Fly    55 ATTQMAQTLDKASAFRPTMAAALDAAAPNRSSNNVAINNISNNGDQRLRLTAALEANLIMSNRNV 119
            ...|.  |..:.|:  .|:...|..:.|:..|..........||..:           :..|.|:
Human  1658 ENKQF--TTPRLSS--TTIPLPLHMSKPSIPSKFTDRRTDQFNGYSK-----------VFGNNNI 1707

  Fly   120 QEQH-------SYRITQDNATSAASIAPNGTAFGD-----APSIPIGVAPA-------------- 158
            .|..       |.||...:............:|..     .|.||...||.
Human  1708 PEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSFPQLGVTRRPQIPTSPAPVMRERKVIPGSYNRI 1772

  Fly   159 ---TTTTID------PATTTPTTTTRRTTRR---PVATTTL------------------------ 187
               :|..:|      |...||.||...:|..   |:.::|.
Human  1773 HSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFF 1837

  Fly   188 --------------KPPPTIDDYQTIISQAGTHAYLPCNVKQLVKKPISWLRMRDGHILTVDQTT 238
                          ||.......||:...|.|....||......|..::|.::..|.::|.:...
Human  1838 AGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI 1902

  Fly   239 FIADQRFQSVFSPNPERWSLQIKYVQLKDEGTYECQVST-EPKASAIVHLRIVEPKTELIGESTR 302
                |||:.:     :..:|.|:.||::|.|.|.|..|. ......:|.|.:...:.:::....:
Human  1903 ----QRFEVL-----KNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ 1958

  Fly   303 HVKA--GSQVKLRCIISQALEPPLFINWFYNQKQIY-----------LH-NR-----------RG 342
            .|..  |..:.:.|:......|.  |:|.:..::::           || ||           ||
Human  1959 DVTVYLGDTIAMECLAKGTPAPQ--ISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021

  Fly   343 ----------------------------WRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTST 379
                                        .:.::|.|.||..:......|.......|........
Human  2022 VYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086

  Fly   380 TPATPSTTATGSTEGATSSETLNGLVTITRSYILDAISQNDVSELGAAAGVAVATETSTAQL-LT 443
            |...||....|           |..|....:..:..::..|.......|...|.:...|.|| :.
Human  2087 TQIRPSQFLHG-----------NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140

  Fly   444 EVEATSSTSGTSTGAGLLASTSAAYAAGAAAGITTAATGDSAATAATTSAW---LTTMDAEAATT 505
            ...|.:..:|||.     ..|...|  |....:..:|:||         .|   |..:.::....
Human  2141 RAAANARITGTSP-----RRTDVRY--GGTLKLDCSASGD---------PWPRILWRLPSKRMID 2189

  Fly   506 AATTTTTMLPSSSFIKQITTASLIIPAVVKLDSGNYTCSPSNS-APRTIVLHV------------ 557
            |      :....|.||.....:|::.:|...|:|:|.|...|. ....:||.|
Human  2190 A------LFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHK 2248

  Fly   558 --------LNGEYSASAIKSG----SVSWS 575
                    ..|:.....:.:|    .:|||
Human  2249 EENDHKVFYGGDLKVDCVATGLPNPEISWS 2278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	24/92 (26%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	21/86 (24%)
MXRA5	NP_056234.2	leucine-rich repeat	38..55	CDD:275380
		LRR_8	55..115	CDD:290566
		LRR 1	56..77
		leucine-rich repeat	57..80	CDD:275380
		LRR 2	80..101
		leucine-rich repeat	81..104	CDD:275380
		LRR_8	102..163	CDD:290566
		LRR 3	104..125
		leucine-rich repeat	105..128	CDD:275380
		LRR_4	128..168	CDD:289563
		LRR 4	128..149
		leucine-rich repeat	129..152	CDD:275380
		LRR 5	152..173
		leucine-rich repeat	153..184	CDD:275380
		LRR 6	184..205
		leucine-rich repeat	185..208	CDD:275380
		LRRCT	217..>263	CDD:214507
		IG	486..572	CDD:214652
		IGc2	493..558	CDD:197706
		IG	590..668	CDD:214652
		IGc2	591..658	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..715
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..962
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1275
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1367..1389
		LRR 7	1410..1434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1479..1499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1536..1566
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1669..1689		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1700..1719		3/29 (10%)
		IG_like	1860..1945	CDD:214653	24/93 (26%)
		Ig	1868..1945	CDD:299845	21/85 (25%)
		I-set	1958..2042	CDD:254352	12/85 (14%)
		IGc2	1965..2032	CDD:197706	11/68 (16%)
		I-set	2047..2139	CDD:254352	18/102 (18%)
		Ig	2065..2137	CDD:299845	12/82 (15%)
		IG_like	2153..2238	CDD:214653	22/106 (21%)
		Ig	2161..2229	CDD:299845	17/82 (21%)
		IG	2258..2341	CDD:214652	5/21 (24%)
		Ig	2258..2332	CDD:299845	5/21 (24%)
		IG_like	2356..2435	CDD:214653
		Ig	2361..2435	CDD:299845
		I-set	2440..2535	CDD:254352
		Ig	2459..2535	CDD:299845
		IG	2549..2633	CDD:214652
		Ig	2561..2633	CDD:299845
		IG	2652..2728	CDD:214652
		Ig	2655..2724	CDD:143165
		IG_like	2741..2827	CDD:214653
		Ig	2751..2824	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910